In search of the sample: recent experiences of a trial team in orthodontics

Susan Cunningham, David Bearn, Philip Benson, Ama Johal, Declan Millett, Kevin O'Brien, Friedy Luther

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)


    Randomised clinical trials are commonly undertaken in medical and dental research. However, few authors discuss the difficulties associated with such studies, including costs, ethical issues and recruitment of an adequate number of patients. There is little information available on the number of studies which are terminated early as a result of these issues, but it seems likely that at least 10% of clinical studies never reach completion.

    This paper reviews two nationally funded clinical studies which were terminated early. It highlights the problems associated with patient recruitment and also some issues which may benefit researchers undertaking similar studies in the future. (C) 2011 Elsevier Inc. All rights reserved.

    Original languageEnglish
    Pages (from-to)530-534
    Number of pages5
    JournalContemporary Clinical Trials
    Issue number4
    Publication statusPublished - Jul 2011


    • Randomised clinical trial
    • Recruitment difficulties
    • Orthodontics
    • Randomized controlled trial
    • Clinical trials
    • Recruitment
    • Prevention
    • Design
    • Feasibility
    • Inform
    • Issues
    • Care


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