Incidence of type 1 diabetes has doubled in Kuwaiti children 0-14 years over the last 20 years

Azza A. Shaltout; Deborah Wake; Thangavel A. Thanaraj; Dina M. Omar; Dalia Al-AbdulRazzaq; Arshad Channanath; Hessa AlKandari; Majedah Abdulrasoul; Sophie Miller; Nicholas Conway; Jaakko Tuomilehto; Lena Davidsson; on behalf of the Steering Group for the Study of Childhood Diabetes in Kuwait

doi:10.1111/pedi.12480

Incidence of type 1 diabetes has doubled in Kuwaiti children 0-14 years over the last 20 years

Azza A. Shaltout (Lead / Corresponding author), Deborah Wake, Thangavel A. Thanaraj, Dina M. Omar, Dalia Al-AbdulRazzaq, Arshad Channanath, Hessa AlKandari, Majedah Abdulrasoul, Sophie Miller, Nicholas Conway, Jaakko Tuomilehto, Lena Davidsson, on behalf of the Steering Group for the Study of Childhood Diabetes in Kuwait

Postgraduate Medicine

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Abstract

Aims: This study had 2 aims: to report data on the incidence of childhood-onset type 1 diabetes in Kuwaiti children aged 0-14 years during 2011 to 2013 and to compare the recent data with those collected during 1992 to 1997.

Methods: All newly diagnosed patients were registered through the Childhood-Onset Diabetes eRegistry (CODeR) in 2011-2013, based on the DiaMond protocol used in 1992-1997.

Results: A total of 515 Kuwaiti children (247 boys and 268 girls) aged 0-14 years newly diagnosed with type 1 diabetes were registered from 1 January 2011 to 31 December 2013. Data ascertainment were 96.7%. The mean age ± SD at diagnosis was 8.7 ± 3.4 years in boys and 7.9 ± 3.1 years in girls. The crude incidence rate (95% CI) was 40.9 (37.4-44.6) and the age standardized rate 41.7 (95% 38.1-45.4) per 100,000 per year, 39.3 (34.6-44.4) among boys and 44.1 (39.0-49.7) among girls. A statistically significant increasing trend in incidence was observed as the overall crude incidence rose from 17.7 in 1992-1994 to 40.9 per 100,000 per year in 2011-2013. The Poisson regression model depicting the trend in incidence revealed that, the incidence rates adjusted for age and sex in 2011 to 2013 was 2.3 (95% CI 1.9-2.7) times higher than 1992-1997.

Conclusions: The incidence of type 1 diabetes in Kuwaiti children 0-14 years has doubled in the last 2 decades. The reasons for this increase requires further investigation.

Original language	English
Pages (from-to)	761-766
Number of pages	6
Journal	Pediatric Diabetes
Volume	18
Issue number	8
Early online date	16 Dec 2016
DOIs	https://doi.org/10.1111/pedi.12480
Publication status	Published - 13 Nov 2017

Keywords

childhood diabetes
type 1 diabetes
epidemiology
incidence
time trend

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/pedi.12480

Author Accepted Manuscript
This is the peer reviewed version of the following article: ‘Incidence of type 1 diabetes has doubled in Kuwaiti children 0-14 years over the last 20 years’, Pediatric Diabetes, which has been published in final form at http://dx.doi.org/10.1111/pedi.12480. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
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Shaltout, A. A., Wake, D., Thanaraj, T. A., Omar, D. M., Al-AbdulRazzaq, D., Channanath, A., AlKandari, H., Abdulrasoul, M., Miller, S., Conway, N., Tuomilehto, J., Davidsson, L., & on behalf of the Steering Group for the Study of Childhood Diabetes in Kuwait (2017). Incidence of type 1 diabetes has doubled in Kuwaiti children 0-14 years over the last 20 years. Pediatric Diabetes, 18(8), 761-766. https://doi.org/10.1111/pedi.12480

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title = "Incidence of type 1 diabetes has doubled in Kuwaiti children 0-14 years over the last 20 years",

abstract = "Aims: This study had 2 aims: to report data on the incidence of childhood-onset type 1 diabetes in Kuwaiti children aged 0-14 years during 2011 to 2013 and to compare the recent data with those collected during 1992 to 1997.Methods: All newly diagnosed patients were registered through the Childhood-Onset Diabetes eRegistry (CODeR) in 2011-2013, based on the DiaMond protocol used in 1992-1997.Results: A total of 515 Kuwaiti children (247 boys and 268 girls) aged 0-14 years newly diagnosed with type 1 diabetes were registered from 1 January 2011 to 31 December 2013. Data ascertainment were 96.7%. The mean age ± SD at diagnosis was 8.7 ± 3.4 years in boys and 7.9 ± 3.1 years in girls. The crude incidence rate (95% CI) was 40.9 (37.4-44.6) and the age standardized rate 41.7 (95% 38.1-45.4) per 100,000 per year, 39.3 (34.6-44.4) among boys and 44.1 (39.0-49.7) among girls. A statistically significant increasing trend in incidence was observed as the overall crude incidence rose from 17.7 in 1992-1994 to 40.9 per 100,000 per year in 2011-2013. The Poisson regression model depicting the trend in incidence revealed that, the incidence rates adjusted for age and sex in 2011 to 2013 was 2.3 (95% CI 1.9-2.7) times higher than 1992-1997.Conclusions: The incidence of type 1 diabetes in Kuwaiti children 0-14 years has doubled in the last 2 decades. The reasons for this increase requires further investigation.",

keywords = "childhood diabetes, type 1 diabetes, epidemiology, incidence, time trend",

author = "Shaltout, {Azza A.} and Deborah Wake and Thanaraj, {Thangavel A.} and Omar, {Dina M.} and Dalia Al-AbdulRazzaq and Arshad Channanath and Hessa AlKandari and Majedah Abdulrasoul and Sophie Miller and Nicholas Conway and Jaakko Tuomilehto and Lena Davidsson and {on behalf of the Steering Group for the Study of Childhood Diabetes in Kuwait}",

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Shaltout, AA, Wake, D, Thanaraj, TA, Omar, DM, Al-AbdulRazzaq, D, Channanath, A, AlKandari, H, Abdulrasoul, M, Miller, S, Conway, N, Tuomilehto, J, Davidsson, L & on behalf of the Steering Group for the Study of Childhood Diabetes in Kuwait 2017, 'Incidence of type 1 diabetes has doubled in Kuwaiti children 0-14 years over the last 20 years', Pediatric Diabetes, vol. 18, no. 8, pp. 761-766. https://doi.org/10.1111/pedi.12480

TY - JOUR

T1 - Incidence of type 1 diabetes has doubled in Kuwaiti children 0-14 years over the last 20 years

AU - Shaltout, Azza A.

AU - Wake, Deborah

AU - Thanaraj, Thangavel A.

AU - Omar, Dina M.

AU - Al-AbdulRazzaq, Dalia

AU - Channanath, Arshad

AU - AlKandari, Hessa

AU - Abdulrasoul, Majedah

AU - Miller, Sophie

AU - Conway, Nicholas

AU - Tuomilehto, Jaakko

AU - Davidsson, Lena

AU - on behalf of the Steering Group for the Study of Childhood Diabetes in Kuwait

N1 - Foundation of Advancement of the Sciences (KFAS) Dasman Diabetes Institute

PY - 2017/11/13

Y1 - 2017/11/13

N2 - Aims: This study had 2 aims: to report data on the incidence of childhood-onset type 1 diabetes in Kuwaiti children aged 0-14 years during 2011 to 2013 and to compare the recent data with those collected during 1992 to 1997.Methods: All newly diagnosed patients were registered through the Childhood-Onset Diabetes eRegistry (CODeR) in 2011-2013, based on the DiaMond protocol used in 1992-1997.Results: A total of 515 Kuwaiti children (247 boys and 268 girls) aged 0-14 years newly diagnosed with type 1 diabetes were registered from 1 January 2011 to 31 December 2013. Data ascertainment were 96.7%. The mean age ± SD at diagnosis was 8.7 ± 3.4 years in boys and 7.9 ± 3.1 years in girls. The crude incidence rate (95% CI) was 40.9 (37.4-44.6) and the age standardized rate 41.7 (95% 38.1-45.4) per 100,000 per year, 39.3 (34.6-44.4) among boys and 44.1 (39.0-49.7) among girls. A statistically significant increasing trend in incidence was observed as the overall crude incidence rose from 17.7 in 1992-1994 to 40.9 per 100,000 per year in 2011-2013. The Poisson regression model depicting the trend in incidence revealed that, the incidence rates adjusted for age and sex in 2011 to 2013 was 2.3 (95% CI 1.9-2.7) times higher than 1992-1997.Conclusions: The incidence of type 1 diabetes in Kuwaiti children 0-14 years has doubled in the last 2 decades. The reasons for this increase requires further investigation.

AB - Aims: This study had 2 aims: to report data on the incidence of childhood-onset type 1 diabetes in Kuwaiti children aged 0-14 years during 2011 to 2013 and to compare the recent data with those collected during 1992 to 1997.Methods: All newly diagnosed patients were registered through the Childhood-Onset Diabetes eRegistry (CODeR) in 2011-2013, based on the DiaMond protocol used in 1992-1997.Results: A total of 515 Kuwaiti children (247 boys and 268 girls) aged 0-14 years newly diagnosed with type 1 diabetes were registered from 1 January 2011 to 31 December 2013. Data ascertainment were 96.7%. The mean age ± SD at diagnosis was 8.7 ± 3.4 years in boys and 7.9 ± 3.1 years in girls. The crude incidence rate (95% CI) was 40.9 (37.4-44.6) and the age standardized rate 41.7 (95% 38.1-45.4) per 100,000 per year, 39.3 (34.6-44.4) among boys and 44.1 (39.0-49.7) among girls. A statistically significant increasing trend in incidence was observed as the overall crude incidence rose from 17.7 in 1992-1994 to 40.9 per 100,000 per year in 2011-2013. The Poisson regression model depicting the trend in incidence revealed that, the incidence rates adjusted for age and sex in 2011 to 2013 was 2.3 (95% CI 1.9-2.7) times higher than 1992-1997.Conclusions: The incidence of type 1 diabetes in Kuwaiti children 0-14 years has doubled in the last 2 decades. The reasons for this increase requires further investigation.

KW - childhood diabetes

KW - type 1 diabetes

KW - epidemiology

KW - incidence

KW - time trend

U2 - 10.1111/pedi.12480

DO - 10.1111/pedi.12480

M3 - Article

C2 - 27981709

SN - 1399-543X

VL - 18

SP - 761

EP - 766

JO - Pediatric Diabetes

JF - Pediatric Diabetes

IS - 8

ER -

Incidence of type 1 diabetes has doubled in Kuwaiti children 0-14 years over the last 20 years

Abstract

Keywords

UN SDGs

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