Increased apoptotic neutrophils and macrophages and impaired macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus

Yi Ren, Jinling Tang, M. Y. Mok, Albert W. K. Chan, C. S. Lau, Adrian Wu

    Research output: Contribution to journalArticle

    255 Citations (Scopus)

    Abstract

    Objective: To evaluate whether patients with systemic lupus erythematosus (SLE) have a higher rate of apoptosis in and secondary necrosis of polymorphonuclear neutrophils (PMNs) and macrophages compared with controls; to compare the rate of macrophage phagocytic clearance of apoptotic PMNs in patients with SLE and healthy controls; to evaluate whether in vitro PMN and macrophage apoptosis and secondary necrosis, and the ability of macrophages to phagocytose apoptotic bodies, are correlated with lupus disease activity; and to determine whether macrophage clearance of apoptotic bodies in patients with SLE and normal controls is related to certain serum factors.
    Original languageEnglish
    Pages (from-to)2888-2897
    Number of pages10
    JournalArthritis & Rheumatism
    Volume48
    Issue number10
    DOIs
    Publication statusPublished - Oct 2003

    Keywords

    • Apoptosis immunology
    • Lupus erythematosus
    • Systemic immunology
    • Macrophages pathology
    • Neutrophils pathology

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