Increased apoptotic neutrophils and macrophages and impaired macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus

Yi Ren, Jinling Tang, M. Y. Mok, Albert W. K. Chan, C. S. Lau, Adrian Wu

    Research output: Contribution to journalArticle

    238 Citations (Scopus)

    Abstract

    Objective: To evaluate whether patients with systemic lupus erythematosus (SLE) have a higher rate of apoptosis in and secondary necrosis of polymorphonuclear neutrophils (PMNs) and macrophages compared with controls; to compare the rate of macrophage phagocytic clearance of apoptotic PMNs in patients with SLE and healthy controls; to evaluate whether in vitro PMN and macrophage apoptosis and secondary necrosis, and the ability of macrophages to phagocytose apoptotic bodies, are correlated with lupus disease activity; and to determine whether macrophage clearance of apoptotic bodies in patients with SLE and normal controls is related to certain serum factors.
    Original languageEnglish
    Pages (from-to)2888-2897
    Number of pages10
    JournalArthritis & Rheumatism
    Volume48
    Issue number10
    DOIs
    Publication statusPublished - Oct 2003

    Fingerprint

    Systemic Lupus Erythematosus
    Neutrophils
    Macrophages
    Necrosis
    Apoptosis
    Phagocytosis
    Serum
    Extracellular Vesicles

    Keywords

    • Apoptosis immunology
    • Lupus erythematosus
    • Systemic immunology
    • Macrophages pathology
    • Neutrophils pathology

    Cite this

    Ren, Yi ; Tang, Jinling ; Mok, M. Y. ; Chan, Albert W. K. ; Lau, C. S. ; Wu, Adrian. / Increased apoptotic neutrophils and macrophages and impaired macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus. In: Arthritis & Rheumatism. 2003 ; Vol. 48, No. 10. pp. 2888-2897.
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    abstract = "Objective: To evaluate whether patients with systemic lupus erythematosus (SLE) have a higher rate of apoptosis in and secondary necrosis of polymorphonuclear neutrophils (PMNs) and macrophages compared with controls; to compare the rate of macrophage phagocytic clearance of apoptotic PMNs in patients with SLE and healthy controls; to evaluate whether in vitro PMN and macrophage apoptosis and secondary necrosis, and the ability of macrophages to phagocytose apoptotic bodies, are correlated with lupus disease activity; and to determine whether macrophage clearance of apoptotic bodies in patients with SLE and normal controls is related to certain serum factors.",
    keywords = "Apoptosis immunology, Lupus erythematosus, Systemic immunology, Macrophages pathology, Neutrophils pathology",
    author = "Yi Ren and Jinling Tang and Mok, {M. Y.} and Chan, {Albert W. K.} and Lau, {C. S.} and Adrian Wu",
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    Increased apoptotic neutrophils and macrophages and impaired macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus. / Ren, Yi; Tang, Jinling; Mok, M. Y.; Chan, Albert W. K.; Lau, C. S.; Wu, Adrian.

    In: Arthritis & Rheumatism, Vol. 48, No. 10, 10.2003, p. 2888-2897.

    Research output: Contribution to journalArticle

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    T1 - Increased apoptotic neutrophils and macrophages and impaired macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus

    AU - Ren, Yi

    AU - Tang, Jinling

    AU - Mok, M. Y.

    AU - Chan, Albert W. K.

    AU - Lau, C. S.

    AU - Wu, Adrian

    N1 - dc.publisher: Wiley-Blackwell

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    AB - Objective: To evaluate whether patients with systemic lupus erythematosus (SLE) have a higher rate of apoptosis in and secondary necrosis of polymorphonuclear neutrophils (PMNs) and macrophages compared with controls; to compare the rate of macrophage phagocytic clearance of apoptotic PMNs in patients with SLE and healthy controls; to evaluate whether in vitro PMN and macrophage apoptosis and secondary necrosis, and the ability of macrophages to phagocytose apoptotic bodies, are correlated with lupus disease activity; and to determine whether macrophage clearance of apoptotic bodies in patients with SLE and normal controls is related to certain serum factors.

    KW - Apoptosis immunology

    KW - Lupus erythematosus

    KW - Systemic immunology

    KW - Macrophages pathology

    KW - Neutrophils pathology

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