Increased apoptotic neutrophils and macrophages and impaired macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus

Yi Ren; Jinling Tang; M. Y. Mok; Albert W. K. Chan; C. S. Lau; Adrian Wu

doi:10.1002/art.11237

Increased apoptotic neutrophils and macrophages and impaired macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus

Yi Ren
, Jinling Tang
, M. Y. Mok
, Albert W. K. Chan
, C. S. Lau
, Adrian Wu

Research output: Contribution to journal › Article › peer-review

320 Citations (Scopus)

Abstract

Objective: To evaluate whether patients with systemic lupus erythematosus (SLE) have a higher rate of apoptosis in and secondary necrosis of polymorphonuclear neutrophils (PMNs) and macrophages compared with controls; to compare the rate of macrophage phagocytic clearance of apoptotic PMNs in patients with SLE and healthy controls; to evaluate whether in vitro PMN and macrophage apoptosis and secondary necrosis, and the ability of macrophages to phagocytose apoptotic bodies, are correlated with lupus disease activity; and to determine whether macrophage clearance of apoptotic bodies in patients with SLE and normal controls is related to certain serum factors.

Original language	English
Pages (from-to)	2888-2897
Number of pages	10
Journal	Arthritis and Rheumatism
Volume	48
Issue number	10
DOIs	https://doi.org/10.1002/art.11237
Publication status	Published - Oct 2003

Keywords

Apoptosis immunology
Lupus erythematosus
Systemic immunology
Macrophages pathology
Neutrophils pathology

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10.1002/art.11237

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title = "Increased apoptotic neutrophils and macrophages and impaired macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus",

abstract = "Objective: To evaluate whether patients with systemic lupus erythematosus (SLE) have a higher rate of apoptosis in and secondary necrosis of polymorphonuclear neutrophils (PMNs) and macrophages compared with controls; to compare the rate of macrophage phagocytic clearance of apoptotic PMNs in patients with SLE and healthy controls; to evaluate whether in vitro PMN and macrophage apoptosis and secondary necrosis, and the ability of macrophages to phagocytose apoptotic bodies, are correlated with lupus disease activity; and to determine whether macrophage clearance of apoptotic bodies in patients with SLE and normal controls is related to certain serum factors.",

keywords = "Apoptosis immunology, Lupus erythematosus, Systemic immunology, Macrophages pathology, Neutrophils pathology",

author = "Yi Ren and Jinling Tang and Mok, \{M. Y.\} and Chan, \{Albert W. K.\} and Lau, \{C. S.\} and Adrian Wu",

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TY - JOUR

T1 - Increased apoptotic neutrophils and macrophages and impaired macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus

AU - Ren, Yi

AU - Tang, Jinling

AU - Mok, M. Y.

AU - Chan, Albert W. K.

AU - Lau, C. S.

AU - Wu, Adrian

N1 - dc.publisher: Wiley-Blackwell

PY - 2003/10

Y1 - 2003/10

N2 - Objective: To evaluate whether patients with systemic lupus erythematosus (SLE) have a higher rate of apoptosis in and secondary necrosis of polymorphonuclear neutrophils (PMNs) and macrophages compared with controls; to compare the rate of macrophage phagocytic clearance of apoptotic PMNs in patients with SLE and healthy controls; to evaluate whether in vitro PMN and macrophage apoptosis and secondary necrosis, and the ability of macrophages to phagocytose apoptotic bodies, are correlated with lupus disease activity; and to determine whether macrophage clearance of apoptotic bodies in patients with SLE and normal controls is related to certain serum factors.

AB - Objective: To evaluate whether patients with systemic lupus erythematosus (SLE) have a higher rate of apoptosis in and secondary necrosis of polymorphonuclear neutrophils (PMNs) and macrophages compared with controls; to compare the rate of macrophage phagocytic clearance of apoptotic PMNs in patients with SLE and healthy controls; to evaluate whether in vitro PMN and macrophage apoptosis and secondary necrosis, and the ability of macrophages to phagocytose apoptotic bodies, are correlated with lupus disease activity; and to determine whether macrophage clearance of apoptotic bodies in patients with SLE and normal controls is related to certain serum factors.

KW - Apoptosis immunology

KW - Lupus erythematosus

KW - Systemic immunology

KW - Macrophages pathology

KW - Neutrophils pathology

U2 - 10.1002/art.11237

DO - 10.1002/art.11237

M3 - Article

SN - 0004-3591

VL - 48

SP - 2888

EP - 2897

JO - Arthritis and Rheumatism

JF - Arthritis and Rheumatism

IS - 10

ER -

Increased apoptotic neutrophils and macrophages and impaired macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus

Abstract

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