Increased granulocyte aggregation in vitro in diabetes mellitus

T. A. Elhadd, A. Bancroft, M. McLaren, R. W. Newton, J. J. F. Belch

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    17 Citations (Scopus)

    Abstract

    Having previously shown an increase in white blood cell (WBC) aggregation in groups known to have a high incidence of cardiovascular events, we compared 28 patients with diabetes mellitus and no history or clinical evidence of macrovascular disease with 28 age- and sex-matched normal controls. Patients and controls had blood taken in the morning and analysed for WBC aggregation in vitro using a whole blood technique. WBC aggregation was significantly higher in the diabetic group compared with the normal controls (mean ± SD 31.10 ± 10.26% vs. 25.7 ± 9.38%; p<0.04, Student t-test). WBC aggregation predates the appearance of clinical symptoms of macrovascular disease in diabetes.

    Original languageEnglish
    Pages (from-to)461-464
    Number of pages4
    JournalQJM : an International Journal of Medicine
    Volume90
    Issue number7
    DOIs
    Publication statusPublished - Jul 1997

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