Increased granulocyte aggregation in vitro in diabetes mellitus

TY - JOUR

T1 - Increased granulocyte aggregation in vitro in diabetes mellitus

AU - Elhadd, T. A.

AU - Bancroft, A.

AU - McLaren, M.

AU - Newton, R. W.

AU - Belch, J. J. F.

PY - 1997/7

Y1 - 1997/7

N2 - Having previously shown an increase in white blood cell (WBC) aggregation in groups known to have a high incidence of cardiovascular events, we compared 28 patients with diabetes mellitus and no history or clinical evidence of macrovascular disease with 28 age- and sex-matched normal controls. Patients and controls had blood taken in the morning and analysed for WBC aggregation in vitro using a whole blood technique. WBC aggregation was significantly higher in the diabetic group compared with the normal controls (mean ± SD 31.10 ± 10.26% vs. 25.7 ± 9.38%; p<0.04, Student t-test). WBC aggregation predates the appearance of clinical symptoms of macrovascular disease in diabetes.

AB - Having previously shown an increase in white blood cell (WBC) aggregation in groups known to have a high incidence of cardiovascular events, we compared 28 patients with diabetes mellitus and no history or clinical evidence of macrovascular disease with 28 age- and sex-matched normal controls. Patients and controls had blood taken in the morning and analysed for WBC aggregation in vitro using a whole blood technique. WBC aggregation was significantly higher in the diabetic group compared with the normal controls (mean ± SD 31.10 ± 10.26% vs. 25.7 ± 9.38%; p<0.04, Student t-test). WBC aggregation predates the appearance of clinical symptoms of macrovascular disease in diabetes.

U2 - 10.1093/qjmed/90.7.461

DO - 10.1093/qjmed/90.7.461

M3 - Article

C2 - 9302430

SN - 1460-2725

VL - 90

SP - 461

EP - 464

JO - QJM : an International Journal of Medicine

JF - QJM : an International Journal of Medicine

IS - 7

ER -