Increased mortality and morbidity in mild primary hyperparathyroid patients. The Parathyroid Epidemiology and Audit Research Study (PEARS)

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    Abstract

    Objective To describe mortality and disease-specific morbidities in patients with mild primary hyperparathyroidism (PHPT).

    Design Retrospective population-based observational study.

    Setting Tayside, Scotland, from 1997 to 2006.

    Participants Patients with mild PHPT were selected from a pre-defined PHPT cohort between 1997 and 2006.

    Main outcome measures Standardised mortality ratios (SMRs) were examined for all-cause mortality, as well as cardiovascular and cancer mortality. Standardised morbidity ratios and standardised incidence ratios were also calculated for eleven observed co-morbidities.

    Results In total, there were 1683 (69 1% female) patients identified with mild PHPT in Tayside. Patients were found to have an increased risk of all-cause mortality and cardiovascular mortality (SMR-all cause 2 62, 95% CI 2.39-2.86; SMR-cardiovascular 2.68, 95% CI 2.34-3.05). Patients with mild PHPT had a significantly increased risk of developing cardiovascular and cerebrovascular disease, renal dysfunction and fractures compared to the age- and sex-adjusted general population.

    Conclusions Mortality and morbidity were increased for patients with mild untreated PHPT, which is similar to more severe PHPT.

    Original languageEnglish
    Pages (from-to)30-34
    Number of pages5
    JournalClinical Endocrinology
    Volume73
    Issue number1
    DOIs
    Publication statusPublished - Jul 2010

    Keywords

    • 3RD INTERNATIONAL WORKSHOP
    • Nationwide cohort analysis
    • Follow-up
    • Thyroid epidemiology
    • Surgery
    • Management
    • Death
    • Population
    • Diagnosis
    • Survival

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