Increased mortality and morbidity in mild primary hyperparathyroid patients. The Parathyroid Epidemiology and Audit Research Study (PEARS)

Ning Yu; Peter T. Donnan; Robert W. V. Flynn; Michael J. Murphy; David Smith; Andrew Rudman; Graham P. Leese

doi:10.1111/j.1365-2265.2009.03766.x

Increased mortality and morbidity in mild primary hyperparathyroid patients. The Parathyroid Epidemiology and Audit Research Study (PEARS)

Ning Yu, Peter T. Donnan, Robert W. V. Flynn, Michael J. Murphy, David Smith, Andrew Rudman, Graham P. Leese

Research output: Contribution to journal › Article › peer-review

166 Citations (Scopus)

Abstract

Objective To describe mortality and disease-specific morbidities in patients with mild primary hyperparathyroidism (PHPT).

Design Retrospective population-based observational study.

Setting Tayside, Scotland, from 1997 to 2006.

Participants Patients with mild PHPT were selected from a pre-defined PHPT cohort between 1997 and 2006.

Main outcome measures Standardised mortality ratios (SMRs) were examined for all-cause mortality, as well as cardiovascular and cancer mortality. Standardised morbidity ratios and standardised incidence ratios were also calculated for eleven observed co-morbidities.

Results In total, there were 1683 (69 1% female) patients identified with mild PHPT in Tayside. Patients were found to have an increased risk of all-cause mortality and cardiovascular mortality (SMR-all cause 2 62, 95% CI 2.39-2.86; SMR-cardiovascular 2.68, 95% CI 2.34-3.05). Patients with mild PHPT had a significantly increased risk of developing cardiovascular and cerebrovascular disease, renal dysfunction and fractures compared to the age- and sex-adjusted general population.

Conclusions Mortality and morbidity were increased for patients with mild untreated PHPT, which is similar to more severe PHPT.

Original language	English
Pages (from-to)	30-34
Number of pages	5
Journal	Clinical Endocrinology
Volume	73
Issue number	1
DOIs	https://doi.org/10.1111/j.1365-2265.2009.03766.x
Publication status	Published - Jul 2010

Keywords

3RD INTERNATIONAL WORKSHOP
Nationwide cohort analysis
Follow-up
Thyroid epidemiology
Surgery
Management
Death
Population
Diagnosis
Survival

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/j.1365-2265.2009.03766.x

Health Informatics Centre
Health and Clinical Services
Facility/equipment: Facility

Cite this

@article{34eb46b6e3ac41d7b7f32c08aadec516,

title = "Increased mortality and morbidity in mild primary hyperparathyroid patients. The Parathyroid Epidemiology and Audit Research Study (PEARS)",

abstract = "Objective To describe mortality and disease-specific morbidities in patients with mild primary hyperparathyroidism (PHPT).Design Retrospective population-based observational study.Setting Tayside, Scotland, from 1997 to 2006.Participants Patients with mild PHPT were selected from a pre-defined PHPT cohort between 1997 and 2006.Main outcome measures Standardised mortality ratios (SMRs) were examined for all-cause mortality, as well as cardiovascular and cancer mortality. Standardised morbidity ratios and standardised incidence ratios were also calculated for eleven observed co-morbidities.Results In total, there were 1683 (69 1% female) patients identified with mild PHPT in Tayside. Patients were found to have an increased risk of all-cause mortality and cardiovascular mortality (SMR-all cause 2 62, 95% CI 2.39-2.86; SMR-cardiovascular 2.68, 95% CI 2.34-3.05). Patients with mild PHPT had a significantly increased risk of developing cardiovascular and cerebrovascular disease, renal dysfunction and fractures compared to the age- and sex-adjusted general population.Conclusions Mortality and morbidity were increased for patients with mild untreated PHPT, which is similar to more severe PHPT.",

keywords = "3RD INTERNATIONAL WORKSHOP, Nationwide cohort analysis, Follow-up, Thyroid epidemiology, Surgery, Management, Death, Population, Diagnosis, Survival",

author = "Ning Yu and Donnan, {Peter T.} and Flynn, {Robert W. V.} and Murphy, {Michael J.} and David Smith and Andrew Rudman and Leese, {Graham P.}",

year = "2010",

month = jul,

doi = "10.1111/j.1365-2265.2009.03766.x",

language = "English",

volume = "73",

pages = "30--34",

journal = "Clinical Endocrinology",

issn = "0300-0664",

publisher = "Wiley-Blackwell",

number = "1",

}

TY - JOUR

T1 - Increased mortality and morbidity in mild primary hyperparathyroid patients. The Parathyroid Epidemiology and Audit Research Study (PEARS)

AU - Yu, Ning

AU - Donnan, Peter T.

AU - Flynn, Robert W. V.

AU - Murphy, Michael J.

AU - Smith, David

AU - Rudman, Andrew

AU - Leese, Graham P.

PY - 2010/7

Y1 - 2010/7

N2 - Objective To describe mortality and disease-specific morbidities in patients with mild primary hyperparathyroidism (PHPT).Design Retrospective population-based observational study.Setting Tayside, Scotland, from 1997 to 2006.Participants Patients with mild PHPT were selected from a pre-defined PHPT cohort between 1997 and 2006.Main outcome measures Standardised mortality ratios (SMRs) were examined for all-cause mortality, as well as cardiovascular and cancer mortality. Standardised morbidity ratios and standardised incidence ratios were also calculated for eleven observed co-morbidities.Results In total, there were 1683 (69 1% female) patients identified with mild PHPT in Tayside. Patients were found to have an increased risk of all-cause mortality and cardiovascular mortality (SMR-all cause 2 62, 95% CI 2.39-2.86; SMR-cardiovascular 2.68, 95% CI 2.34-3.05). Patients with mild PHPT had a significantly increased risk of developing cardiovascular and cerebrovascular disease, renal dysfunction and fractures compared to the age- and sex-adjusted general population.Conclusions Mortality and morbidity were increased for patients with mild untreated PHPT, which is similar to more severe PHPT.

AB - Objective To describe mortality and disease-specific morbidities in patients with mild primary hyperparathyroidism (PHPT).Design Retrospective population-based observational study.Setting Tayside, Scotland, from 1997 to 2006.Participants Patients with mild PHPT were selected from a pre-defined PHPT cohort between 1997 and 2006.Main outcome measures Standardised mortality ratios (SMRs) were examined for all-cause mortality, as well as cardiovascular and cancer mortality. Standardised morbidity ratios and standardised incidence ratios were also calculated for eleven observed co-morbidities.Results In total, there were 1683 (69 1% female) patients identified with mild PHPT in Tayside. Patients were found to have an increased risk of all-cause mortality and cardiovascular mortality (SMR-all cause 2 62, 95% CI 2.39-2.86; SMR-cardiovascular 2.68, 95% CI 2.34-3.05). Patients with mild PHPT had a significantly increased risk of developing cardiovascular and cerebrovascular disease, renal dysfunction and fractures compared to the age- and sex-adjusted general population.Conclusions Mortality and morbidity were increased for patients with mild untreated PHPT, which is similar to more severe PHPT.

KW - 3RD INTERNATIONAL WORKSHOP

KW - Nationwide cohort analysis

KW - Follow-up

KW - Thyroid epidemiology

KW - Surgery

KW - Management

KW - Death

KW - Population

KW - Diagnosis

KW - Survival

U2 - 10.1111/j.1365-2265.2009.03766.x

DO - 10.1111/j.1365-2265.2009.03766.x

M3 - Article

C2 - 20039887

SN - 0300-0664

VL - 73

SP - 30

EP - 34

JO - Clinical Endocrinology

JF - Clinical Endocrinology

IS - 1

ER -

Increased mortality and morbidity in mild primary hyperparathyroid patients. The Parathyroid Epidemiology and Audit Research Study (PEARS)

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Equipment

Health Informatics Centre

Cite this