Increased mortality and morbidity in mild primary hyperparathyroid patients. The Parathyroid Epidemiology and Audit Research Study (PEARS)

TY - JOUR

T1 - Increased mortality and morbidity in mild primary hyperparathyroid patients. The Parathyroid Epidemiology and Audit Research Study (PEARS)

AU - Yu, Ning

AU - Donnan, Peter T.

AU - Flynn, Robert W. V.

AU - Murphy, Michael J.

AU - Smith, David

AU - Rudman, Andrew

AU - Leese, Graham P.

PY - 2010/7

Y1 - 2010/7

N2 - Objective To describe mortality and disease-specific morbidities in patients with mild primary hyperparathyroidism (PHPT).Design Retrospective population-based observational study.Setting Tayside, Scotland, from 1997 to 2006.Participants Patients with mild PHPT were selected from a pre-defined PHPT cohort between 1997 and 2006.Main outcome measures Standardised mortality ratios (SMRs) were examined for all-cause mortality, as well as cardiovascular and cancer mortality. Standardised morbidity ratios and standardised incidence ratios were also calculated for eleven observed co-morbidities.Results In total, there were 1683 (69 1% female) patients identified with mild PHPT in Tayside. Patients were found to have an increased risk of all-cause mortality and cardiovascular mortality (SMR-all cause 2 62, 95% CI 2.39-2.86; SMR-cardiovascular 2.68, 95% CI 2.34-3.05). Patients with mild PHPT had a significantly increased risk of developing cardiovascular and cerebrovascular disease, renal dysfunction and fractures compared to the age- and sex-adjusted general population.Conclusions Mortality and morbidity were increased for patients with mild untreated PHPT, which is similar to more severe PHPT.

AB - Objective To describe mortality and disease-specific morbidities in patients with mild primary hyperparathyroidism (PHPT).Design Retrospective population-based observational study.Setting Tayside, Scotland, from 1997 to 2006.Participants Patients with mild PHPT were selected from a pre-defined PHPT cohort between 1997 and 2006.Main outcome measures Standardised mortality ratios (SMRs) were examined for all-cause mortality, as well as cardiovascular and cancer mortality. Standardised morbidity ratios and standardised incidence ratios were also calculated for eleven observed co-morbidities.Results In total, there were 1683 (69 1% female) patients identified with mild PHPT in Tayside. Patients were found to have an increased risk of all-cause mortality and cardiovascular mortality (SMR-all cause 2 62, 95% CI 2.39-2.86; SMR-cardiovascular 2.68, 95% CI 2.34-3.05). Patients with mild PHPT had a significantly increased risk of developing cardiovascular and cerebrovascular disease, renal dysfunction and fractures compared to the age- and sex-adjusted general population.Conclusions Mortality and morbidity were increased for patients with mild untreated PHPT, which is similar to more severe PHPT.

KW - 3RD INTERNATIONAL WORKSHOP

KW - Nationwide cohort analysis

KW - Follow-up

KW - Thyroid epidemiology

KW - Surgery

KW - Management

KW - Death

KW - Population

KW - Diagnosis

KW - Survival

U2 - 10.1111/j.1365-2265.2009.03766.x

DO - 10.1111/j.1365-2265.2009.03766.x

M3 - Article

C2 - 20039887

SN - 0300-0664

VL - 73

SP - 30

EP - 34

JO - Clinical Endocrinology

JF - Clinical Endocrinology

IS - 1

ER -