Increased neutrophil apoptosis in chronic fatigue syndrome

G Kennedy; V Spence; C Underwood; J J F Belch

doi:10.1136/jcp.2003.015511

Increased neutrophil apoptosis in chronic fatigue syndrome

G Kennedy, V Spence, C Underwood, J J F Belch

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Abstract

Background/Aims: Many patients with chronic fatigue syndrome (CFS) have symptoms that are consistent with an underlying viral or toxic illness. Because increased neutrophil apoptosis occurs in patients with infection, this study examined whether this phenomenon also occurs in patients with CFS.
Methods: Apoptosis was assessed in patients with CFS in conjunction with concentrations of the anti-inflammatory cytokine, transforming growth factor ß1 (TGFß1).
Results: The 47 patients with CFS had higher numbers of apoptotic neutrophils, lower numbers of viable neutrophils, increased annexin V binding, and increased expression of the death receptor, tumour necrosis factor receptor-I, on their neutrophils than did the 34 healthy controls. Patients with CFS also had raised concentrations of active TGFß1 (p < 0.005).
Conclusions: These findings provide new evidence that patients with CFS have an underlying detectable abnormality in their immune cells.

Original language	English
Pages (from-to)	891-893
Number of pages	3
Journal	Journal of Clinical Pathology
Volume	57
Issue number	8
DOIs	https://doi.org/10.1136/jcp.2003.015511
Publication status	Published - Aug 2004

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title = "Increased neutrophil apoptosis in chronic fatigue syndrome",

abstract = "Background/Aims: Many patients with chronic fatigue syndrome (CFS) have symptoms that are consistent with an underlying viral or toxic illness. Because increased neutrophil apoptosis occurs in patients with infection, this study examined whether this phenomenon also occurs in patients with CFS. Methods: Apoptosis was assessed in patients with CFS in conjunction with concentrations of the anti-inflammatory cytokine, transforming growth factor {\ss}1 (TGF{\ss}1). Results: The 47 patients with CFS had higher numbers of apoptotic neutrophils, lower numbers of viable neutrophils, increased annexin V binding, and increased expression of the death receptor, tumour necrosis factor receptor-I, on their neutrophils than did the 34 healthy controls. Patients with CFS also had raised concentrations of active TGF{\ss}1 (p < 0.005). Conclusions: These findings provide new evidence that patients with CFS have an underlying detectable abnormality in their immune cells.",

author = "G Kennedy and V Spence and C Underwood and Belch, {J J F}",

year = "2004",

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doi = "10.1136/jcp.2003.015511",

language = "English",

volume = "57",

pages = "891--893",

journal = "Journal of Clinical Pathology",

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publisher = "BMJ Publishing Group",

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T1 - Increased neutrophil apoptosis in chronic fatigue syndrome

AU - Kennedy, G

AU - Spence, V

AU - Underwood, C

AU - Belch, J J F

PY - 2004/8

Y1 - 2004/8

N2 - Background/Aims: Many patients with chronic fatigue syndrome (CFS) have symptoms that are consistent with an underlying viral or toxic illness. Because increased neutrophil apoptosis occurs in patients with infection, this study examined whether this phenomenon also occurs in patients with CFS. Methods: Apoptosis was assessed in patients with CFS in conjunction with concentrations of the anti-inflammatory cytokine, transforming growth factor ß1 (TGFß1). Results: The 47 patients with CFS had higher numbers of apoptotic neutrophils, lower numbers of viable neutrophils, increased annexin V binding, and increased expression of the death receptor, tumour necrosis factor receptor-I, on their neutrophils than did the 34 healthy controls. Patients with CFS also had raised concentrations of active TGFß1 (p < 0.005). Conclusions: These findings provide new evidence that patients with CFS have an underlying detectable abnormality in their immune cells.

AB - Background/Aims: Many patients with chronic fatigue syndrome (CFS) have symptoms that are consistent with an underlying viral or toxic illness. Because increased neutrophil apoptosis occurs in patients with infection, this study examined whether this phenomenon also occurs in patients with CFS. Methods: Apoptosis was assessed in patients with CFS in conjunction with concentrations of the anti-inflammatory cytokine, transforming growth factor ß1 (TGFß1). Results: The 47 patients with CFS had higher numbers of apoptotic neutrophils, lower numbers of viable neutrophils, increased annexin V binding, and increased expression of the death receptor, tumour necrosis factor receptor-I, on their neutrophils than did the 34 healthy controls. Patients with CFS also had raised concentrations of active TGFß1 (p < 0.005). Conclusions: These findings provide new evidence that patients with CFS have an underlying detectable abnormality in their immune cells.

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DO - 10.1136/jcp.2003.015511

M3 - Article

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SN - 0021-9746

VL - 57

SP - 891

EP - 893

JO - Journal of Clinical Pathology

JF - Journal of Clinical Pathology

IS - 8

ER -

Increased neutrophil apoptosis in chronic fatigue syndrome

Abstract

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