Increased neutrophil apoptosis in chronic fatigue syndrome

G Kennedy, V Spence, C Underwood, J J F Belch

    Research output: Contribution to journalArticle

    45 Citations (Scopus)

    Abstract

    Background/Aims: Many patients with chronic fatigue syndrome (CFS) have symptoms that are consistent with an underlying viral or toxic illness. Because increased neutrophil apoptosis occurs in patients with infection, this study examined whether this phenomenon also occurs in patients with CFS.
    Methods: Apoptosis was assessed in patients with CFS in conjunction with concentrations of the anti-inflammatory cytokine, transforming growth factor ß1 (TGFß1).
    Results: The 47 patients with CFS had higher numbers of apoptotic neutrophils, lower numbers of viable neutrophils, increased annexin V binding, and increased expression of the death receptor, tumour necrosis factor receptor-I, on their neutrophils than did the 34 healthy controls. Patients with CFS also had raised concentrations of active TGFß1 (p < 0.005).
    Conclusions: These findings provide new evidence that patients with CFS have an underlying detectable abnormality in their immune cells.

    Original languageEnglish
    Pages (from-to)891-893
    Number of pages3
    JournalJournal of Clinical Pathology
    Volume57
    Issue number8
    DOIs
    Publication statusPublished - Aug 2004

    Fingerprint

    Chronic Fatigue Syndrome
    Neutrophils
    Apoptosis
    Transforming Growth Factors
    Death Domain Receptors
    Tumor Necrosis Factor Receptors
    Poisons
    Annexin A5
    Anti-Inflammatory Agents
    Cytokines
    Infection

    Cite this

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    title = "Increased neutrophil apoptosis in chronic fatigue syndrome",
    abstract = "Background/Aims: Many patients with chronic fatigue syndrome (CFS) have symptoms that are consistent with an underlying viral or toxic illness. Because increased neutrophil apoptosis occurs in patients with infection, this study examined whether this phenomenon also occurs in patients with CFS. Methods: Apoptosis was assessed in patients with CFS in conjunction with concentrations of the anti-inflammatory cytokine, transforming growth factor {\ss}1 (TGF{\ss}1). Results: The 47 patients with CFS had higher numbers of apoptotic neutrophils, lower numbers of viable neutrophils, increased annexin V binding, and increased expression of the death receptor, tumour necrosis factor receptor-I, on their neutrophils than did the 34 healthy controls. Patients with CFS also had raised concentrations of active TGF{\ss}1 (p < 0.005). Conclusions: These findings provide new evidence that patients with CFS have an underlying detectable abnormality in their immune cells.",
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    Increased neutrophil apoptosis in chronic fatigue syndrome. / Kennedy, G; Spence, V; Underwood, C; Belch, J J F.

    In: Journal of Clinical Pathology, Vol. 57, No. 8, 08.2004, p. 891-893.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Increased neutrophil apoptosis in chronic fatigue syndrome

    AU - Kennedy, G

    AU - Spence, V

    AU - Underwood, C

    AU - Belch, J J F

    PY - 2004/8

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    N2 - Background/Aims: Many patients with chronic fatigue syndrome (CFS) have symptoms that are consistent with an underlying viral or toxic illness. Because increased neutrophil apoptosis occurs in patients with infection, this study examined whether this phenomenon also occurs in patients with CFS. Methods: Apoptosis was assessed in patients with CFS in conjunction with concentrations of the anti-inflammatory cytokine, transforming growth factor ß1 (TGFß1). Results: The 47 patients with CFS had higher numbers of apoptotic neutrophils, lower numbers of viable neutrophils, increased annexin V binding, and increased expression of the death receptor, tumour necrosis factor receptor-I, on their neutrophils than did the 34 healthy controls. Patients with CFS also had raised concentrations of active TGFß1 (p < 0.005). Conclusions: These findings provide new evidence that patients with CFS have an underlying detectable abnormality in their immune cells.

    AB - Background/Aims: Many patients with chronic fatigue syndrome (CFS) have symptoms that are consistent with an underlying viral or toxic illness. Because increased neutrophil apoptosis occurs in patients with infection, this study examined whether this phenomenon also occurs in patients with CFS. Methods: Apoptosis was assessed in patients with CFS in conjunction with concentrations of the anti-inflammatory cytokine, transforming growth factor ß1 (TGFß1). Results: The 47 patients with CFS had higher numbers of apoptotic neutrophils, lower numbers of viable neutrophils, increased annexin V binding, and increased expression of the death receptor, tumour necrosis factor receptor-I, on their neutrophils than did the 34 healthy controls. Patients with CFS also had raised concentrations of active TGFß1 (p < 0.005). Conclusions: These findings provide new evidence that patients with CFS have an underlying detectable abnormality in their immune cells.

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