Increased production of α-melanocyte-stimulating hormone in the pituitary gland of patients with untreated Addison's disease

P. J. Coates, A. M. McNicol, I. Doniach, L. H. Rees

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    There is evidence that peptides related to alpha-melanocyte-stimulating hormone (alpha-MSH) are involved in regulating the zona glomerulosa of the adrenal cortex in certain species. We have investigated the amount of immunoreactive (IR)-alpha-MSH in the human pituitary gland of patients suffering from Addison's disease. We show increased numbers of cells containing demonstrable IR-alpha-MSH in the anterior lobe in these patients. Using an antiserum with specificity for the acetylated N-terminus of alpha-MSH we suggest that the major form present is desacetyl-alpha-MSH. These findings are in keeping with a role for anterior lobe derived desacetyl-alpha-MSH in the regulation of the human adrenal cortex.
    Original languageEnglish
    Pages (from-to)421-6
    Number of pages6
    JournalClinical Endocrinology
    Volume29
    Issue number4
    DOIs
    Publication statusPublished - 1988

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