Increased production of α-melanocyte-stimulating hormone in the pituitary gland of patients with untreated Addison's disease

P. J. Coates; A. M. McNicol; I. Doniach; L. H. Rees

doi:10.1111/j.1365-2265.1988.tb02891.x

Increased production of α-melanocyte-stimulating hormone in the pituitary gland of patients with untreated Addison's disease

P. J. Coates, A. M. McNicol, I. Doniach, L. H. Rees

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

There is evidence that peptides related to alpha-melanocyte-stimulating hormone (alpha-MSH) are involved in regulating the zona glomerulosa of the adrenal cortex in certain species. We have investigated the amount of immunoreactive (IR)-alpha-MSH in the human pituitary gland of patients suffering from Addison's disease. We show increased numbers of cells containing demonstrable IR-alpha-MSH in the anterior lobe in these patients. Using an antiserum with specificity for the acetylated N-terminus of alpha-MSH we suggest that the major form present is desacetyl-alpha-MSH. These findings are in keeping with a role for anterior lobe derived desacetyl-alpha-MSH in the regulation of the human adrenal cortex.

Original language	English
Pages (from-to)	421-6
Number of pages	6
Journal	Clinical Endocrinology
Volume	29
Issue number	4
DOIs	https://doi.org/10.1111/j.1365-2265.1988.tb02891.x
Publication status	Published - 1988

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title = "Increased production of α-melanocyte-stimulating hormone in the pituitary gland of patients with untreated Addison's disease",

abstract = "There is evidence that peptides related to alpha-melanocyte-stimulating hormone (alpha-MSH) are involved in regulating the zona glomerulosa of the adrenal cortex in certain species. We have investigated the amount of immunoreactive (IR)-alpha-MSH in the human pituitary gland of patients suffering from Addison's disease. We show increased numbers of cells containing demonstrable IR-alpha-MSH in the anterior lobe in these patients. Using an antiserum with specificity for the acetylated N-terminus of alpha-MSH we suggest that the major form present is desacetyl-alpha-MSH. These findings are in keeping with a role for anterior lobe derived desacetyl-alpha-MSH in the regulation of the human adrenal cortex.",

author = "Coates, {P. J.} and McNicol, {A. M.} and I. Doniach and Rees, {L. H.}",

year = "1988",

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T1 - Increased production of α-melanocyte-stimulating hormone in the pituitary gland of patients with untreated Addison's disease

AU - Coates, P. J.

AU - McNicol, A. M.

AU - Doniach, I.

AU - Rees, L. H.

PY - 1988

Y1 - 1988

N2 - There is evidence that peptides related to alpha-melanocyte-stimulating hormone (alpha-MSH) are involved in regulating the zona glomerulosa of the adrenal cortex in certain species. We have investigated the amount of immunoreactive (IR)-alpha-MSH in the human pituitary gland of patients suffering from Addison's disease. We show increased numbers of cells containing demonstrable IR-alpha-MSH in the anterior lobe in these patients. Using an antiserum with specificity for the acetylated N-terminus of alpha-MSH we suggest that the major form present is desacetyl-alpha-MSH. These findings are in keeping with a role for anterior lobe derived desacetyl-alpha-MSH in the regulation of the human adrenal cortex.

AB - There is evidence that peptides related to alpha-melanocyte-stimulating hormone (alpha-MSH) are involved in regulating the zona glomerulosa of the adrenal cortex in certain species. We have investigated the amount of immunoreactive (IR)-alpha-MSH in the human pituitary gland of patients suffering from Addison's disease. We show increased numbers of cells containing demonstrable IR-alpha-MSH in the anterior lobe in these patients. Using an antiserum with specificity for the acetylated N-terminus of alpha-MSH we suggest that the major form present is desacetyl-alpha-MSH. These findings are in keeping with a role for anterior lobe derived desacetyl-alpha-MSH in the regulation of the human adrenal cortex.

U2 - 10.1111/j.1365-2265.1988.tb02891.x

DO - 10.1111/j.1365-2265.1988.tb02891.x

M3 - Article

C2 - 2855222

SN - 0300-0664

VL - 29

SP - 421

EP - 426

JO - Clinical Endocrinology

JF - Clinical Endocrinology

IS - 4

ER -

Increased production of α-melanocyte-stimulating hormone in the pituitary gland of patients with untreated Addison's disease

Abstract

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