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Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System
Luke M. Simpson
, Thomas J. Macartney
, Alice Nardin
, Luke J. Fulcher
, Sascha Röth
, Andrea Testa
, Chiara Maniaci
,
Alessio Ciulli
,
Ian G. Ganley
,
Gopal P. Sapkota
(Lead / Corresponding author)
MRC PPU
Biological Chemistry and Drug Discovery
Research output
:
Contribution to journal
›
Article
›
peer-review
58
Citations (Scopus)
206
Downloads (Pure)
Overview
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(1)
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Dive into the research topics of 'Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System'. Together they form a unique fingerprint.
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Keyphrases
Protein of Interest
100%
Missile System
100%
Inducible Degradation
100%
HaloTag
80%
Proteolysis Targeting chimera (PROTAC)
60%
Intracellular Protein
40%
Enhanced Green Fluorescent Protein (eGFP)
40%
Polypeptide
40%
Binder
40%
AdPROM
40%
GFP Nanobody
40%
GFP Tagging
20%
E3 Ubiquitin Ligase
20%
K-ras
20%
HEC-RAS
20%
ULK1
20%
Tuneability
20%
Ras Proteins
20%
Cas9 Protein
20%
SGK3
20%
Targeted Proteolysis
20%
Monobody
20%
FAM83D
20%
Biochemistry, Genetics and Molecular Biology
Proteolysis
100%
Single-Domain Antibody
50%
Ubiquitin-Conjugating Enzyme
25%
ULK1
25%
CRISPR/Cas9
25%