Induction of endogenous β-galactosidase by ionizing radiation complicates the analysis of p53-LacZ transgenic mice

Philip Coates, Sally Lorimore, Brigitte A. Rigat, David Lane, Eric Wright

    Research output: Contribution to journalArticlepeer-review

    14 Citations (Scopus)

    Abstract

    Studies of the response of p53-lacZ transgenic mice have uncovered an unexpected induction of endogenous acid--galactosidase activity following whole body irradiation. Strong induction of endogenous enzyme activity is seen in a variety of mouse strains commonly used in the production of transgenes. The induction of endogenous enzyme activity therefore complicates the analysis of p53-lacZ transgenes and may also influence the analysis of radiation responses in other lacZ-reporter mice.
    Original languageEnglish
    Pages (from-to)7096-7097
    Number of pages2
    JournalOncogene
    Volume20
    Issue number48
    DOIs
    Publication statusPublished - Oct 2001

    Keywords

    • lacZ
    • β-galactosidase
    • Radiation
    • Macrophage
    • Transgenic mice

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