Infantile acute liver failure in the West of Scotland

David Wands, Rachel Tayler, Deirdre Kelly, Fernando Pinto, Judith Helen Simpson, Richard Hansen

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Background: Our current understanding regarding the aetiology of infantile acute liver failure largely derives from studies conducted by regional liver units. This may introduce selection bias and therefore not provide a true reflection of the wider population. 

Methods: Every coagulation screen with a prothrombin time ≥18 s in our centre was examined over one calendar year. All patients less than 1 year of age were included and their electronic records retrospectively reviewed. 

Results: 24 patients were identified, from 9989 coagulation screens, that fit the current definition of acute liver failure. Hypoxic birth injury and ischaemic events were the most common aetiologies. Survival was 75%. 

Conclusion: The 'catch-all' methodology employed demonstrated that acute liver failure is more common than previously reported and suggests that current data may exclude large numbers who either have more minor self-resolving disease or conversely have severe disease leading to death prior to transfer.

Original languageEnglish
Pages (from-to)794-796
Number of pages3
JournalArchives of Disease in Childhood
Issue number8
Early online date12 Nov 2019
Publication statusPublished - 20 Jun 2020


  • acute liver failure
  • gastroenterology
  • hepatology
  • paediatric

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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