Infantile acute liver failure in the West of Scotland

David Wands, Rachel Tayler, Deirdre Kelly, Fernando Pinto, Judith Helen Simpson, Richard Hansen

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)


    Background: Our current understanding regarding the aetiology of infantile acute liver failure largely derives from studies conducted by regional liver units. This may introduce selection bias and therefore not provide a true reflection of the wider population. 

    Methods: Every coagulation screen with a prothrombin time ≥18 s in our centre was examined over one calendar year. All patients less than 1 year of age were included and their electronic records retrospectively reviewed. 

    Results: 24 patients were identified, from 9989 coagulation screens, that fit the current definition of acute liver failure. Hypoxic birth injury and ischaemic events were the most common aetiologies. Survival was 75%. 

    Conclusion: The 'catch-all' methodology employed demonstrated that acute liver failure is more common than previously reported and suggests that current data may exclude large numbers who either have more minor self-resolving disease or conversely have severe disease leading to death prior to transfer.

    Original languageEnglish
    Pages (from-to)794-796
    Number of pages3
    JournalArchives of Disease in Childhood
    Issue number8
    Early online date12 Nov 2019
    Publication statusPublished - 20 Jun 2020


    • acute liver failure
    • gastroenterology
    • hepatology
    • paediatric

    ASJC Scopus subject areas

    • Pediatrics, Perinatology, and Child Health


    Dive into the research topics of 'Infantile acute liver failure in the West of Scotland'. Together they form a unique fingerprint.

    Cite this