Inflammatory breast cancer: the disease, the biology, the treatment

Fredika M. Robertson, Melissa Bondy, Wei Yang, Hideko Yamauchi, Shannon Wiggins, Samira Kamrudin, Savitri Krishnamurthy, Huong Le-Petross, Luc Bidaut, Audrey N. Player, Sanford H. Barsky, Wendy A. Woodward, Thomas Buchholz, Anthony Lucci, Naoto Ueno, Massimo Cristofanilli

    Research output: Contribution to journalArticlepeer-review

    278 Citations (Scopus)


    Inflammatory breast cancer (IBC) is a rare and aggressive form of invasive breast cancer accounting for 2.5% of all breast cancer cases. It is characterized by rapid progression, local and distant metastases, younger age of onset, and lower overall survival compared with other breast cancers. Historically, IBC is a lethal disease with less than a 5% survival rate beyond 5 years when treated with surgery or radiation therapy. Because of its rarity, IBC is often misdiagnosed as mastitis or generalized dermatitis. This review examines IBC's unique clinical presentation, pathology, epidemiology, imaging, and biology and details current multidisciplinary management of the disease, which comprises systemic therapy, surgery, and radiation therapy. CA Cancer J Clin 2010;60:351-375. (C) 2010 American Cancer Society, Inc.

    Original languageEnglish
    Pages (from-to)351-375
    Number of pages25
    JournalCA: a Cancer Journal for Clinicians
    Issue number6
    Publication statusPublished - 2010


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    • Growth factor receptor
    • Epitheleal mesenchymal transition
    • Lymph node metastases
    • Human melanoma cells
    • Body mass index
    • Neoadjuvant chemotherapy
    • Vasculogenic mimicry
    • Gene expression


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