Influence of carotid artery stenting on cognitive function

Iris Quasar Grunwald; Panagiotis Papanagiotou; Wolfgang Reith; Martin Backens; Tilman Supprian; Maria Politi; Verena Vedder; K Zercher; B Muscalla; Anton Haass; Christoph M. Krick

doi:10.1007/s00234-009-0618-4

Influence of carotid artery stenting on cognitive function

Iris Quasar Grunwald (Lead / Corresponding author), Panagiotis Papanagiotou, Wolfgang Reith, Martin Backens, Tilman Supprian, Maria Politi, Verena Vedder, K Zercher, B Muscalla, Anton Haass, Christoph M. Krick

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

Introduction: There have only been a few studies on cognitive changes in patients with carotid occlusive disease, and the results of these show major discrepancies in the extent to which treatment affects neuropsychological function. We sought to clarify these discrepancies by evaluating the effects of carotid artery stenting (CAS) on the cognitive function.

Methods: Forty-one asymptomatic CAS patients were administered a test battery of neuropsychological tests measuring cognitive speed and memory function before and 3 months after the procedure. A control group was also evaluated. To test for thromboembolic lesions, diffusion-weighted imaging was used.

Results: CAS led to a significant increase in cognitive speed (p<0.001) but did not afford any change in memory function. This was regardless of the degree or side of stenosis or patient age or gender.

Conclusion: CAS significantly improved functions that involve cognitive speed. Earlier studies did not differentiate between speed and memory tests and thus might have missed these changes. Further studies correlating changes in brain perfusion with increase in cognitive speed are needed.

Original language	English
Pages (from-to)	61-66
Number of pages	6
Journal	Neuroradiology
Volume	52
Issue number	1
Early online date	4 Nov 2009
DOIs	https://doi.org/10.1007/s00234-009-0618-4
Publication status	Published - Jan 2010

Keywords

Aged
Aging
Angioplasty
Brain/pathology
Carotid Arteries/pathology
Carotid Stenosis/pathology
Cognition/physiology
Diffusion Magnetic Resonance Imaging
Female
Humans
Male
Memory/physiology
Middle Aged
Neuropsychological Tests
Sex Characteristics
Stents
Time Factors
Treatment Outcome

Access to Document

10.1007/s00234-009-0618-4

Cite this

@article{d4efa232c9314b9682e1273da662b5cd,

title = "Influence of carotid artery stenting on cognitive function",

abstract = "Introduction: There have only been a few studies on cognitive changes in patients with carotid occlusive disease, and the results of these show major discrepancies in the extent to which treatment affects neuropsychological function. We sought to clarify these discrepancies by evaluating the effects of carotid artery stenting (CAS) on the cognitive function.Methods: Forty-one asymptomatic CAS patients were administered a test battery of neuropsychological tests measuring cognitive speed and memory function before and 3 months after the procedure. A control group was also evaluated. To test for thromboembolic lesions, diffusion-weighted imaging was used.Results: CAS led to a significant increase in cognitive speed (p<0.001) but did not afford any change in memory function. This was regardless of the degree or side of stenosis or patient age or gender.Conclusion: CAS significantly improved functions that involve cognitive speed. Earlier studies did not differentiate between speed and memory tests and thus might have missed these changes. Further studies correlating changes in brain perfusion with increase in cognitive speed are needed.",

keywords = "Aged, Aging, Angioplasty, Brain/pathology, Carotid Arteries/pathology, Carotid Stenosis/pathology, Cognition/physiology, Diffusion Magnetic Resonance Imaging, Female, Humans, Male, Memory/physiology, Middle Aged, Neuropsychological Tests, Sex Characteristics, Stents, Time Factors, Treatment Outcome",

author = "Grunwald, {Iris Quasar} and Panagiotis Papanagiotou and Wolfgang Reith and Martin Backens and Tilman Supprian and Maria Politi and Verena Vedder and K Zercher and B Muscalla and Anton Haass and Krick, {Christoph M.}",

year = "2010",

month = jan,

doi = "10.1007/s00234-009-0618-4",

language = "English",

volume = "52",

pages = "61--66",

journal = "Neuroradiology",

issn = "0028-3940",

publisher = "Springer Verlag",

number = "1",

}

TY - JOUR

T1 - Influence of carotid artery stenting on cognitive function

AU - Grunwald, Iris Quasar

AU - Papanagiotou, Panagiotis

AU - Reith, Wolfgang

AU - Backens, Martin

AU - Supprian, Tilman

AU - Politi, Maria

AU - Vedder, Verena

AU - Zercher, K

AU - Muscalla, B

AU - Haass, Anton

AU - Krick, Christoph M.

PY - 2010/1

Y1 - 2010/1

N2 - Introduction: There have only been a few studies on cognitive changes in patients with carotid occlusive disease, and the results of these show major discrepancies in the extent to which treatment affects neuropsychological function. We sought to clarify these discrepancies by evaluating the effects of carotid artery stenting (CAS) on the cognitive function.Methods: Forty-one asymptomatic CAS patients were administered a test battery of neuropsychological tests measuring cognitive speed and memory function before and 3 months after the procedure. A control group was also evaluated. To test for thromboembolic lesions, diffusion-weighted imaging was used.Results: CAS led to a significant increase in cognitive speed (p<0.001) but did not afford any change in memory function. This was regardless of the degree or side of stenosis or patient age or gender.Conclusion: CAS significantly improved functions that involve cognitive speed. Earlier studies did not differentiate between speed and memory tests and thus might have missed these changes. Further studies correlating changes in brain perfusion with increase in cognitive speed are needed.

AB - Introduction: There have only been a few studies on cognitive changes in patients with carotid occlusive disease, and the results of these show major discrepancies in the extent to which treatment affects neuropsychological function. We sought to clarify these discrepancies by evaluating the effects of carotid artery stenting (CAS) on the cognitive function.Methods: Forty-one asymptomatic CAS patients were administered a test battery of neuropsychological tests measuring cognitive speed and memory function before and 3 months after the procedure. A control group was also evaluated. To test for thromboembolic lesions, diffusion-weighted imaging was used.Results: CAS led to a significant increase in cognitive speed (p<0.001) but did not afford any change in memory function. This was regardless of the degree or side of stenosis or patient age or gender.Conclusion: CAS significantly improved functions that involve cognitive speed. Earlier studies did not differentiate between speed and memory tests and thus might have missed these changes. Further studies correlating changes in brain perfusion with increase in cognitive speed are needed.

KW - Aged

KW - Aging

KW - Angioplasty

KW - Brain/pathology

KW - Carotid Arteries/pathology

KW - Carotid Stenosis/pathology

KW - Cognition/physiology

KW - Diffusion Magnetic Resonance Imaging

KW - Female

KW - Humans

KW - Male

KW - Memory/physiology

KW - Middle Aged

KW - Neuropsychological Tests

KW - Sex Characteristics

KW - Stents

KW - Time Factors

KW - Treatment Outcome

U2 - 10.1007/s00234-009-0618-4

DO - 10.1007/s00234-009-0618-4

M3 - Article

C2 - 20033798

SN - 0028-3940

VL - 52

SP - 61

EP - 66

JO - Neuroradiology

JF - Neuroradiology

IS - 1

ER -

Influence of carotid artery stenting on cognitive function

Abstract

Keywords

Access to Document

Fingerprint

Cite this