Influence of region of interest size and ultrasound lesion size on the performance of 2D shear wave elastography (SWE) in solid breast masses

K. Skerl; S. Vinnicombe; E. Giannotti; K. Thomson; A. Evans

doi:10.1016/j.crad.2015.08.010

Influence of region of interest size and ultrasound lesion size on the performance of 2D shear wave elastography (SWE) in solid breast masses

K. Skerl (Lead / Corresponding author), S. Vinnicombe, E. Giannotti, K. Thomson, A. Evans

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

AIM: To evaluate the influence of the region of interest (ROI) size and lesion diameter on the diagnostic performance of 2D shear wave elastography (SWE) of solid breast lesions.

MATERIALS AND METHODS: A study group of 206 consecutive patients (age range 21-92 years) with 210 solid breast lesions (70 benign, 140 malignant) who underwent core biopsy or surgical excision was evaluated. Lesions were divided into small (diameter <15 mm, n=112) and large lesions (diameter ≥15 mm, n=98). An ROI with a diameter of 1, 2, and 3 mm was positioned over the stiffest part of the lesion. The maximum elasticity (Emax), mean elasticity (Emean) and standard deviation (SD) for each ROI size were compared to the pathological outcome. Statistical analysis was undertaken using the chi-square test and receiver operating characteristic (ROC) analysis.

RESULTS: The ROI size used has a significant impact on the performance of Emean and SD but not on Emax. Youden's indices show a correlation with the ROI size and lesion size: generally, the benign/malignant threshold is lower with increasing ROI size but higher with increasing lesion size.

CONCLUSIONS: No single SWE parameter has superior performance. Lesion size and ROI size influence diagnostic performance.

Original language	English
Pages (from-to)	1421-1427
Number of pages	7
Journal	Clinical Radiology
Volume	70
Issue number	12
Early online date	9 Oct 2015
DOIs	https://doi.org/10.1016/j.crad.2015.08.010
Publication status	Published - Dec 2015

Keywords

Adult
Aged
Aged, 80 and over
Breast
Breast neoplasms
Diagnosis, Differential
Elasticity Imaging Techniques
Female
Humans
Middle aged
ROC curve
Reproducibility of results
Sensitivity and specificity
Ultrasonography, Mammary
Young adult

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title = "Influence of region of interest size and ultrasound lesion size on the performance of 2D shear wave elastography (SWE) in solid breast masses",

abstract = "AIM: To evaluate the influence of the region of interest (ROI) size and lesion diameter on the diagnostic performance of 2D shear wave elastography (SWE) of solid breast lesions.MATERIALS AND METHODS: A study group of 206 consecutive patients (age range 21-92 years) with 210 solid breast lesions (70 benign, 140 malignant) who underwent core biopsy or surgical excision was evaluated. Lesions were divided into small (diameter <15 mm, n=112) and large lesions (diameter ≥15 mm, n=98). An ROI with a diameter of 1, 2, and 3 mm was positioned over the stiffest part of the lesion. The maximum elasticity (Emax), mean elasticity (Emean) and standard deviation (SD) for each ROI size were compared to the pathological outcome. Statistical analysis was undertaken using the chi-square test and receiver operating characteristic (ROC) analysis.RESULTS: The ROI size used has a significant impact on the performance of Emean and SD but not on Emax. Youden's indices show a correlation with the ROI size and lesion size: generally, the benign/malignant threshold is lower with increasing ROI size but higher with increasing lesion size.CONCLUSIONS: No single SWE parameter has superior performance. Lesion size and ROI size influence diagnostic performance.",

keywords = "Adult, Aged, Aged, 80 and over, Breast, Breast neoplasms, Diagnosis, Differential, Elasticity Imaging Techniques, Female, Humans, Middle aged, ROC curve, Reproducibility of results, Sensitivity and specificity, Ultrasonography, Mammary, Young adult",

author = "K. Skerl and S. Vinnicombe and E. Giannotti and K. Thomson and A. Evans",

note = "Copyright {\textcopyright} 2015. Published by Elsevier Ltd.",

year = "2015",

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doi = "10.1016/j.crad.2015.08.010",

language = "English",

volume = "70",

pages = "1421--1427",

journal = "Clinical Radiology",

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T1 - Influence of region of interest size and ultrasound lesion size on the performance of 2D shear wave elastography (SWE) in solid breast masses

AU - Skerl, K.

AU - Vinnicombe, S.

AU - Giannotti, E.

AU - Thomson, K.

AU - Evans, A.

PY - 2015/12

Y1 - 2015/12

N2 - AIM: To evaluate the influence of the region of interest (ROI) size and lesion diameter on the diagnostic performance of 2D shear wave elastography (SWE) of solid breast lesions.MATERIALS AND METHODS: A study group of 206 consecutive patients (age range 21-92 years) with 210 solid breast lesions (70 benign, 140 malignant) who underwent core biopsy or surgical excision was evaluated. Lesions were divided into small (diameter <15 mm, n=112) and large lesions (diameter ≥15 mm, n=98). An ROI with a diameter of 1, 2, and 3 mm was positioned over the stiffest part of the lesion. The maximum elasticity (Emax), mean elasticity (Emean) and standard deviation (SD) for each ROI size were compared to the pathological outcome. Statistical analysis was undertaken using the chi-square test and receiver operating characteristic (ROC) analysis.RESULTS: The ROI size used has a significant impact on the performance of Emean and SD but not on Emax. Youden's indices show a correlation with the ROI size and lesion size: generally, the benign/malignant threshold is lower with increasing ROI size but higher with increasing lesion size.CONCLUSIONS: No single SWE parameter has superior performance. Lesion size and ROI size influence diagnostic performance.

AB - AIM: To evaluate the influence of the region of interest (ROI) size and lesion diameter on the diagnostic performance of 2D shear wave elastography (SWE) of solid breast lesions.MATERIALS AND METHODS: A study group of 206 consecutive patients (age range 21-92 years) with 210 solid breast lesions (70 benign, 140 malignant) who underwent core biopsy or surgical excision was evaluated. Lesions were divided into small (diameter <15 mm, n=112) and large lesions (diameter ≥15 mm, n=98). An ROI with a diameter of 1, 2, and 3 mm was positioned over the stiffest part of the lesion. The maximum elasticity (Emax), mean elasticity (Emean) and standard deviation (SD) for each ROI size were compared to the pathological outcome. Statistical analysis was undertaken using the chi-square test and receiver operating characteristic (ROC) analysis.RESULTS: The ROI size used has a significant impact on the performance of Emean and SD but not on Emax. Youden's indices show a correlation with the ROI size and lesion size: generally, the benign/malignant threshold is lower with increasing ROI size but higher with increasing lesion size.CONCLUSIONS: No single SWE parameter has superior performance. Lesion size and ROI size influence diagnostic performance.

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KW - Aged

KW - Aged, 80 and over

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KW - Breast neoplasms

KW - Diagnosis, Differential

KW - Elasticity Imaging Techniques

KW - Female

KW - Humans

KW - Middle aged

KW - ROC curve

KW - Reproducibility of results

KW - Sensitivity and specificity

KW - Ultrasonography, Mammary

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JO - Clinical Radiology

JF - Clinical Radiology

IS - 12

ER -

Influence of region of interest size and ultrasound lesion size on the performance of 2D shear wave elastography (SWE) in solid breast masses

Abstract

Keywords

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