Influence of region of interest size and ultrasound lesion size on the performance of 2D shear wave elastography (SWE) in solid breast masses

K. Skerl (Lead / Corresponding author), S. Vinnicombe, E. Giannotti, K. Thomson, A. Evans

    Research output: Contribution to journalArticle

    26 Citations (Scopus)

    Abstract

    AIM: To evaluate the influence of the region of interest (ROI) size and lesion diameter on the diagnostic performance of 2D shear wave elastography (SWE) of solid breast lesions.

    MATERIALS AND METHODS: A study group of 206 consecutive patients (age range 21-92 years) with 210 solid breast lesions (70 benign, 140 malignant) who underwent core biopsy or surgical excision was evaluated. Lesions were divided into small (diameter <15 mm, n=112) and large lesions (diameter ≥15 mm, n=98). An ROI with a diameter of 1, 2, and 3 mm was positioned over the stiffest part of the lesion. The maximum elasticity (Emax), mean elasticity (Emean) and standard deviation (SD) for each ROI size were compared to the pathological outcome. Statistical analysis was undertaken using the chi-square test and receiver operating characteristic (ROC) analysis.

    RESULTS: The ROI size used has a significant impact on the performance of Emean and SD but not on Emax. Youden's indices show a correlation with the ROI size and lesion size: generally, the benign/malignant threshold is lower with increasing ROI size but higher with increasing lesion size.

    CONCLUSIONS: No single SWE parameter has superior performance. Lesion size and ROI size influence diagnostic performance.

    Original languageEnglish
    Pages (from-to)1421-1427
    Number of pages7
    JournalClinical Radiology
    Volume70
    Issue number12
    Early online date9 Oct 2015
    DOIs
    Publication statusPublished - Dec 2015

    Keywords

    • Adult
    • Aged
    • Aged, 80 and over
    • Breast
    • Breast neoplasms
    • Diagnosis, Differential
    • Elasticity Imaging Techniques
    • Female
    • Humans
    • Middle aged
    • ROC curve
    • Reproducibility of results
    • Sensitivity and specificity
    • Ultrasonography, Mammary
    • Young adult

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