Influence of region of interest size and ultrasound lesion size on the performance of 2D shear wave elastography (SWE) in solid breast masses

K. Skerl (Lead / Corresponding author), S. Vinnicombe, E. Giannotti, K. Thomson, A. Evans

    Research output: Contribution to journalArticle

    21 Citations (Scopus)

    Abstract

    AIM: To evaluate the influence of the region of interest (ROI) size and lesion diameter on the diagnostic performance of 2D shear wave elastography (SWE) of solid breast lesions.

    MATERIALS AND METHODS: A study group of 206 consecutive patients (age range 21-92 years) with 210 solid breast lesions (70 benign, 140 malignant) who underwent core biopsy or surgical excision was evaluated. Lesions were divided into small (diameter <15 mm, n=112) and large lesions (diameter ≥15 mm, n=98). An ROI with a diameter of 1, 2, and 3 mm was positioned over the stiffest part of the lesion. The maximum elasticity (Emax), mean elasticity (Emean) and standard deviation (SD) for each ROI size were compared to the pathological outcome. Statistical analysis was undertaken using the chi-square test and receiver operating characteristic (ROC) analysis.

    RESULTS: The ROI size used has a significant impact on the performance of Emean and SD but not on Emax. Youden's indices show a correlation with the ROI size and lesion size: generally, the benign/malignant threshold is lower with increasing ROI size but higher with increasing lesion size.

    CONCLUSIONS: No single SWE parameter has superior performance. Lesion size and ROI size influence diagnostic performance.

    Original languageEnglish
    Pages (from-to)1421-1427
    Number of pages7
    JournalClinical Radiology
    Volume70
    Issue number12
    Early online date9 Oct 2015
    DOIs
    Publication statusPublished - Dec 2015

    Fingerprint

    Elasticity Imaging Techniques
    Elasticity
    Breast
    Chi-Square Distribution
    ROC Curve
    Biopsy

    Keywords

    • Adult
    • Aged
    • Aged, 80 and over
    • Breast
    • Breast neoplasms
    • Diagnosis, Differential
    • Elasticity Imaging Techniques
    • Female
    • Humans
    • Middle aged
    • ROC curve
    • Reproducibility of results
    • Sensitivity and specificity
    • Ultrasonography, Mammary
    • Young adult

    Cite this

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    title = "Influence of region of interest size and ultrasound lesion size on the performance of 2D shear wave elastography (SWE) in solid breast masses",
    abstract = "AIM: To evaluate the influence of the region of interest (ROI) size and lesion diameter on the diagnostic performance of 2D shear wave elastography (SWE) of solid breast lesions.MATERIALS AND METHODS: A study group of 206 consecutive patients (age range 21-92 years) with 210 solid breast lesions (70 benign, 140 malignant) who underwent core biopsy or surgical excision was evaluated. Lesions were divided into small (diameter <15 mm, n=112) and large lesions (diameter ≥15 mm, n=98). An ROI with a diameter of 1, 2, and 3 mm was positioned over the stiffest part of the lesion. The maximum elasticity (Emax), mean elasticity (Emean) and standard deviation (SD) for each ROI size were compared to the pathological outcome. Statistical analysis was undertaken using the chi-square test and receiver operating characteristic (ROC) analysis.RESULTS: The ROI size used has a significant impact on the performance of Emean and SD but not on Emax. Youden's indices show a correlation with the ROI size and lesion size: generally, the benign/malignant threshold is lower with increasing ROI size but higher with increasing lesion size.CONCLUSIONS: No single SWE parameter has superior performance. Lesion size and ROI size influence diagnostic performance.",
    keywords = "Adult, Aged, Aged, 80 and over, Breast, Breast neoplasms, Diagnosis, Differential, Elasticity Imaging Techniques, Female, Humans, Middle aged, ROC curve, Reproducibility of results, Sensitivity and specificity, Ultrasonography, Mammary, Young adult",
    author = "K. Skerl and S. Vinnicombe and E. Giannotti and K. Thomson and A. Evans",
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    Influence of region of interest size and ultrasound lesion size on the performance of 2D shear wave elastography (SWE) in solid breast masses. / Skerl, K. (Lead / Corresponding author); Vinnicombe, S.; Giannotti, E.; Thomson, K.; Evans, A.

    In: Clinical Radiology, Vol. 70, No. 12, 12.2015, p. 1421-1427.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Influence of region of interest size and ultrasound lesion size on the performance of 2D shear wave elastography (SWE) in solid breast masses

    AU - Skerl, K.

    AU - Vinnicombe, S.

    AU - Giannotti, E.

    AU - Thomson, K.

    AU - Evans, A.

    N1 - Copyright © 2015. Published by Elsevier Ltd.

    PY - 2015/12

    Y1 - 2015/12

    N2 - AIM: To evaluate the influence of the region of interest (ROI) size and lesion diameter on the diagnostic performance of 2D shear wave elastography (SWE) of solid breast lesions.MATERIALS AND METHODS: A study group of 206 consecutive patients (age range 21-92 years) with 210 solid breast lesions (70 benign, 140 malignant) who underwent core biopsy or surgical excision was evaluated. Lesions were divided into small (diameter <15 mm, n=112) and large lesions (diameter ≥15 mm, n=98). An ROI with a diameter of 1, 2, and 3 mm was positioned over the stiffest part of the lesion. The maximum elasticity (Emax), mean elasticity (Emean) and standard deviation (SD) for each ROI size were compared to the pathological outcome. Statistical analysis was undertaken using the chi-square test and receiver operating characteristic (ROC) analysis.RESULTS: The ROI size used has a significant impact on the performance of Emean and SD but not on Emax. Youden's indices show a correlation with the ROI size and lesion size: generally, the benign/malignant threshold is lower with increasing ROI size but higher with increasing lesion size.CONCLUSIONS: No single SWE parameter has superior performance. Lesion size and ROI size influence diagnostic performance.

    AB - AIM: To evaluate the influence of the region of interest (ROI) size and lesion diameter on the diagnostic performance of 2D shear wave elastography (SWE) of solid breast lesions.MATERIALS AND METHODS: A study group of 206 consecutive patients (age range 21-92 years) with 210 solid breast lesions (70 benign, 140 malignant) who underwent core biopsy or surgical excision was evaluated. Lesions were divided into small (diameter <15 mm, n=112) and large lesions (diameter ≥15 mm, n=98). An ROI with a diameter of 1, 2, and 3 mm was positioned over the stiffest part of the lesion. The maximum elasticity (Emax), mean elasticity (Emean) and standard deviation (SD) for each ROI size were compared to the pathological outcome. Statistical analysis was undertaken using the chi-square test and receiver operating characteristic (ROC) analysis.RESULTS: The ROI size used has a significant impact on the performance of Emean and SD but not on Emax. Youden's indices show a correlation with the ROI size and lesion size: generally, the benign/malignant threshold is lower with increasing ROI size but higher with increasing lesion size.CONCLUSIONS: No single SWE parameter has superior performance. Lesion size and ROI size influence diagnostic performance.

    KW - Adult

    KW - Aged

    KW - Aged, 80 and over

    KW - Breast

    KW - Breast neoplasms

    KW - Diagnosis, Differential

    KW - Elasticity Imaging Techniques

    KW - Female

    KW - Humans

    KW - Middle aged

    KW - ROC curve

    KW - Reproducibility of results

    KW - Sensitivity and specificity

    KW - Ultrasonography, Mammary

    KW - Young adult

    U2 - 10.1016/j.crad.2015.08.010

    DO - 10.1016/j.crad.2015.08.010

    M3 - Article

    VL - 70

    SP - 1421

    EP - 1427

    JO - Clinical Radiology

    JF - Clinical Radiology

    SN - 0009-9260

    IS - 12

    ER -