Influenza A viruses alter the stability and antiviral contribution of host E3-ubiquitin ligase Mdm2 during the time-course of infection

Andrés Pizzorno, Julia Dubois, Daniela Machado, Gaëlle Cartet, Aurelien Traversier, Thomas Julien, Bruno Lina, Jean-Christophe Bourdon, Manuel Rosa-Calatrava, Olivier Terrier (Lead / Corresponding author)

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    7 Citations (Scopus)
    189 Downloads (Pure)

    Abstract

    The interplay between influenza A viruses (IAV) and the p53 pathway has been reported in several studies, highlighting the antiviral contribution of p53. Here, we investigated the impact of IAV on the E3-ubiquitin ligase Mdm2, a major regulator of p53, and observed that IAV targets Mdm2, notably via its non-structural protein (NS1), therefore altering Mdm2 stability, p53/Mdm2 interaction and regulatory loop during the time-course of infection. This study also highlights a new antiviral facet of Mdm2 possibly increasing the list of its many p53-independent functions. Altogether, our work contributes to better understand the mechanisms underlining the complex interactions between IAV and the p53 pathway, for which both NS1 and Mdm2 arise as key players.

    Original languageEnglish
    Article number3746
    Pages (from-to)1-13
    Number of pages13
    JournalScientific Reports
    Volume8
    DOIs
    Publication statusPublished - 27 Feb 2018

    Keywords

    • Journal article
    • Influenza virus
    • Virus-host interactions

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