Influenza NS1 interacts with p53 and alters its binding to p53-responsive genes, in a promoter-dependent manner

Olivier Terrier, Audrey Diederichs, Julia Dubois, Gaëlle Cartet, Bruno Lina, Jean-Christophe Bourdon, Manuel Rosa-Calatrava

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    The interplay between influenza A viruses (IAV) and p53 has only been reported in a limited number of studies, mainly focusing on the antiviral role of p53. We investigated the impact of IAV infection on p53 stability and transcriptional activity. Our results indicate that IAV-induced stabilization of p53 only partially correlates with modulation of p53 transcriptional activity measured during infection. Moreover, we show that the viral non-structural protein 1 (NS1) is able to inhibit p53 transcriptional activity, in a promoter-dependent manner. Based on these data, we propose that NS1 may contribute to p53-mediated cell fate decision during IAV infection.
    Original languageEnglish
    Pages (from-to)2965-2971
    Number of pages7
    JournalFEBS Letters
    Volume587
    Issue number18
    DOIs
    Publication statusPublished - 13 Aug 2013

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