Inhaled and Systemic Corticosteroid Response in Severe Asthma Assessed by Alveolar Nitric Oxide: a randomised crossover pilot study of add-on therapy

Peter A Williamson, Philip M Short, Sriram Vaidyanathan, Brian J Lipworth

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    11 Citations (Scopus)


    Aims: Alveolar nitric oxide (CA(NO) ) is a potential biomarker of small airway inflammation. We investigated effects on CA(NO) of the addition of coarse and fine particle inhaled corticosteroids to standard therapy in severe asthma. Methods: Severe asthmatics taking =1600µg/day budesonide or equivalent performed a randomised open-label crossover study. Subjects with FEV(1)
    Original languageEnglish
    Pages (from-to)93-102
    Number of pages10
    JournalBritish Journal of Clinical Pharmacology
    Issue number1
    Publication statusPublished - Jan 2013


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