Inhaled and Systemic Corticosteroid Response in Severe Asthma Assessed by Alveolar Nitric Oxide

a randomised crossover pilot study of add-on therapy

Peter A Williamson, Philip M Short, Sriram Vaidyanathan, Brian J Lipworth

    Research output: Contribution to journalArticle

    10 Citations (Scopus)

    Abstract

    Aims: Alveolar nitric oxide (CA(NO) ) is a potential biomarker of small airway inflammation. We investigated effects on CA(NO) of the addition of coarse and fine particle inhaled corticosteroids to standard therapy in severe asthma. Methods: Severe asthmatics taking =1600µg/day budesonide or equivalent performed a randomised open-label crossover study. Subjects with FEV(1)
    Original languageEnglish
    Pages (from-to)93-102
    Number of pages10
    JournalBritish Journal of Clinical Pharmacology
    Volume75
    Issue number1
    DOIs
    Publication statusPublished - Jan 2013

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    Cross-Over Studies
    Adrenal Cortex Hormones
    Nitric Oxide
    Asthma
    Budesonide
    Biomarkers
    Inflammation
    Therapeutics

    Cite this

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    title = "Inhaled and Systemic Corticosteroid Response in Severe Asthma Assessed by Alveolar Nitric Oxide: a randomised crossover pilot study of add-on therapy",
    abstract = "Aims: Alveolar nitric oxide (CA(NO) ) is a potential biomarker of small airway inflammation. We investigated effects on CA(NO) of the addition of coarse and fine particle inhaled corticosteroids to standard therapy in severe asthma. Methods: Severe asthmatics taking =1600µg/day budesonide or equivalent performed a randomised open-label crossover study. Subjects with FEV(1)",
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    Inhaled and Systemic Corticosteroid Response in Severe Asthma Assessed by Alveolar Nitric Oxide : a randomised crossover pilot study of add-on therapy. / Williamson, Peter A; Short, Philip M; Vaidyanathan, Sriram; Lipworth, Brian J.

    In: British Journal of Clinical Pharmacology, Vol. 75, No. 1, 01.2013, p. 93-102.

    Research output: Contribution to journalArticle

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    AU - Short, Philip M

    AU - Vaidyanathan, Sriram

    AU - Lipworth, Brian J

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    AB - Aims: Alveolar nitric oxide (CA(NO) ) is a potential biomarker of small airway inflammation. We investigated effects on CA(NO) of the addition of coarse and fine particle inhaled corticosteroids to standard therapy in severe asthma. Methods: Severe asthmatics taking =1600µg/day budesonide or equivalent performed a randomised open-label crossover study. Subjects with FEV(1)

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