Inhibitors of dihydrofolate reductase in leishmania and trypanosomes

Ian H  Gilbert

doi:10.1016/S0925-4439(02)00088-1

Inhibitors of dihydrofolate reductase in leishmania and trypanosomes

Ian H Gilbert

Research output: Contribution to journal › Article › peer-review

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Abstract

The protozoan diseases leishmaniasis, Chagas' disease and African trypanosomiasis are major health problems in many countries, particularly developing countries, and there are few drugs available to treat these diseases. Dihydrofolate reductase (DHFR) inhibitors have been used successfully in the treatment of a number of other diseases such as cancer, malaria and bacterial infections; however they have not been used for the treatment of these diseases. This article summarises studies on leishmanial and trypanosomal DHFR inhibitor development and evaluation. Possible mechanisms of resistance to DHFR inhibitors are also discussed. (C) 2002 Elsevier Science B.V All rights reserved.

Original language	English
Pages (from-to)	249-257
Number of pages	9
Journal	BBA - Molecular Basis of Disease
Volume	1587
Issue number	2-3
DOIs	https://doi.org/10.1016/S0925-4439(02)00088-1
Publication status	Published - 18 Jul 2002

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abstract = "The protozoan diseases leishmaniasis, Chagas' disease and African trypanosomiasis are major health problems in many countries, particularly developing countries, and there are few drugs available to treat these diseases. Dihydrofolate reductase (DHFR) inhibitors have been used successfully in the treatment of a number of other diseases such as cancer, malaria and bacterial infections; however they have not been used for the treatment of these diseases. This article summarises studies on leishmanial and trypanosomal DHFR inhibitor development and evaluation. Possible mechanisms of resistance to DHFR inhibitors are also discussed. (C) 2002 Elsevier Science B.V All rights reserved.",

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AB - The protozoan diseases leishmaniasis, Chagas' disease and African trypanosomiasis are major health problems in many countries, particularly developing countries, and there are few drugs available to treat these diseases. Dihydrofolate reductase (DHFR) inhibitors have been used successfully in the treatment of a number of other diseases such as cancer, malaria and bacterial infections; however they have not been used for the treatment of these diseases. This article summarises studies on leishmanial and trypanosomal DHFR inhibitor development and evaluation. Possible mechanisms of resistance to DHFR inhibitors are also discussed. (C) 2002 Elsevier Science B.V All rights reserved.

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Inhibitors of dihydrofolate reductase in leishmania and trypanosomes

Abstract

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