Inhibitors of dihydrofolate reductase in leishmania and trypanosomes

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    Abstract

    The protozoan diseases leishmaniasis, Chagas' disease and African trypanosomiasis are major health problems in many countries, particularly developing countries, and there are few drugs available to treat these diseases. Dihydrofolate reductase (DHFR) inhibitors have been used successfully in the treatment of a number of other diseases such as cancer, malaria and bacterial infections; however they have not been used for the treatment of these diseases. This article summarises studies on leishmanial and trypanosomal DHFR inhibitor development and evaluation. Possible mechanisms of resistance to DHFR inhibitors are also discussed. (C) 2002 Elsevier Science B.V All rights reserved.

    Original languageEnglish
    Pages (from-to)249-257
    Number of pages9
    JournalBiochimica et Biophysica Acta. Molecular Basis of Disease
    Volume1587
    Issue number2-3
    DOIs
    Publication statusPublished - 18 Jul 2002

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