Inhibitors of dihydrofolate reductase in leishmania and trypanosomes

TY - JOUR

T1 - Inhibitors of dihydrofolate reductase in leishmania and trypanosomes

AU - Gilbert, Ian H

PY - 2002/7/18

Y1 - 2002/7/18

N2 - The protozoan diseases leishmaniasis, Chagas' disease and African trypanosomiasis are major health problems in many countries, particularly developing countries, and there are few drugs available to treat these diseases. Dihydrofolate reductase (DHFR) inhibitors have been used successfully in the treatment of a number of other diseases such as cancer, malaria and bacterial infections; however they have not been used for the treatment of these diseases. This article summarises studies on leishmanial and trypanosomal DHFR inhibitor development and evaluation. Possible mechanisms of resistance to DHFR inhibitors are also discussed. (C) 2002 Elsevier Science B.V All rights reserved.

AB - The protozoan diseases leishmaniasis, Chagas' disease and African trypanosomiasis are major health problems in many countries, particularly developing countries, and there are few drugs available to treat these diseases. Dihydrofolate reductase (DHFR) inhibitors have been used successfully in the treatment of a number of other diseases such as cancer, malaria and bacterial infections; however they have not been used for the treatment of these diseases. This article summarises studies on leishmanial and trypanosomal DHFR inhibitor development and evaluation. Possible mechanisms of resistance to DHFR inhibitors are also discussed. (C) 2002 Elsevier Science B.V All rights reserved.

U2 - 10.1016/S0925-4439(02)00088-1

DO - 10.1016/S0925-4439(02)00088-1

M3 - Article

SN - 0925-4439

VL - 1587

SP - 249

EP - 257

JO - BBA - Molecular Basis of Disease

JF - BBA - Molecular Basis of Disease

IS - 2-3

ER -