Inhibitors of protein kinases and phosphatases

Carol MacKintosh, Robert W. MacKintosh

    Research output: Contribution to journalReview article

    232 Citations (Scopus)

    Abstract

    Inhibitors of eukaryotic protein kinases and phosphatases are a chemically diverse array of natural and synthetic compounds, including medicines, potions and poisons. These substances are valuable pharmacological probes and affinity ligands for the kinases and phosphatases of signalling pathways, enhancing our knowledge of the cellular effects of the pathway in question. More broadly, this basic research is also leading to the development of drugs to control specific cellular responses, and enzyme-based assays to detect toxins in food and water.

    Original languageEnglish
    Pages (from-to)444-448
    Number of pages5
    JournalTrends in Biochemical Sciences
    Volume19
    Issue number11
    DOIs
    Publication statusPublished - 1994

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