@article{2397fcd849d947d9ad157908d449170e,
title = "Initiating a crystallographic study of trypanothione reductase",
abstract = "We have obtained well-ordered single crystals of the flavoenzyme trypanothione reductase from Crithidia fasciculata. The crystals are tetragonal rods with unit cell dimensions a = 128·6 {\AA}, c = 92·5 {\AA}. The diffraction pattern corresponds to a primitive lattice, Laue class 4/m. Diffraction to better than 2·4 {\AA} has been recorded at the Daresbury Synchrotron. The accurate elucidation of the three-dimensional structure of this enzyme is required to support the rational design of compounds active against a variety of tropical diseases caused by trypanosomal parasites.",
author = "Hunter, {William N.} and Keith Smith and Zygmunt Derewenda and Harrop, {Stephen J.} and Jarjis Habash and Islam, {M. S.} and Helliwell, {John R.} and Fairlamb, {Alan H.}",
note = "Funding Information: We gratefully acknowledge the encouragement and interaction of Ken Douglas and co-workers in the Department of Pharmacy at Manchester University. Colin Jackson, Colin Nave, Andy Thompson and Miroslav Papiz of the Daresbury Laboratory are thanked for their excellent support. M.S.I. is supported by the Commonwealth Scholarship Commission in the United Kingdom. Our studies are funded by the Wellcome Trust, the National Institutes of Health, U.S.A. (AI21429), the Hasselblad Foundation (for provision of a scanner), the University of Manchester and the SERC (U.K.).",
year = "1990",
month = nov,
day = "20",
doi = "10.1016/S0022-2836(05)80314-6",
language = "English",
volume = "216",
pages = "235--237",
journal = "Journal of Molecular Biology",
issn = "0022-2836",
publisher = "Academic Press",
number = "2",
}
