Innate DNA sensing moves to the nucleus

Leonie Unterholzner, Andrew G Bowie

    Research output: Contribution to journalArticle

    19 Citations (Scopus)

    Abstract

    It has been assumed that cells distinguish viral from cellular DNA due to the former's presence in the cytosol. However, in this issue, Kerur et al. (2011) propose that the DNA genome of Kaposi's sarcoma-associated herpesvirus (KSHV) is recognized inside the nucleus by the DNA sensor IFI16, leading inflammasome activation.
    Original languageEnglish
    Pages (from-to)351-353
    Number of pages3
    JournalCell Host & Microbe
    Volume9
    Issue number5
    DOIs
    Publication statusPublished - 19 May 2011

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