Innate DNA sensing moves to the nucleus

Leonie Unterholzner; Andrew G Bowie

doi:10.1016/j.chom.2011.05.001

Innate DNA sensing moves to the nucleus

Leonie Unterholzner, Andrew G Bowie

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

It has been assumed that cells distinguish viral from cellular DNA due to the former's presence in the cytosol. However, in this issue, Kerur et al. (2011) propose that the DNA genome of Kaposi's sarcoma-associated herpesvirus (KSHV) is recognized inside the nucleus by the DNA sensor IFI16, leading inflammasome activation.

Original language	English
Pages (from-to)	351-353
Number of pages	3
Journal	Cell Host & Microbe
Volume	9
Issue number	5
DOIs	https://doi.org/10.1016/j.chom.2011.05.001
Publication status	Published - 19 May 2011

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10.1016/j.chom.2011.05.001

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title = "Innate DNA sensing moves to the nucleus",

abstract = "It has been assumed that cells distinguish viral from cellular DNA due to the former's presence in the cytosol. However, in this issue, Kerur et al. (2011) propose that the DNA genome of Kaposi's sarcoma-associated herpesvirus (KSHV) is recognized inside the nucleus by the DNA sensor IFI16, leading inflammasome activation.",

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AB - It has been assumed that cells distinguish viral from cellular DNA due to the former's presence in the cytosol. However, in this issue, Kerur et al. (2011) propose that the DNA genome of Kaposi's sarcoma-associated herpesvirus (KSHV) is recognized inside the nucleus by the DNA sensor IFI16, leading inflammasome activation.

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DO - 10.1016/j.chom.2011.05.001

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JO - Cell Host & Microbe

JF - Cell Host & Microbe

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Innate DNA sensing moves to the nucleus

Abstract

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