Innovative vaccine approaches-a Keystone Symposia report

Jennifer Cable; Rino Rappuoli; Elizabeth J. Klemm; Gagandeep Kang; Ankur Mutreja; Gavin J. Wright; Mariagrazia Pizza; Sowmya Ajay Castro; Joseph P. Hoffmann; Galit Alter; Andrea Carfi; Andrew J. Pollard; Florian Krammer; Ravindra K. Gupta; Caroline E. Wagner; Viviane Machado; Kayvon Modjarrad; Lawrence Corey; Peter B. Gilbert; Gordon Dougan; Nicole Lurie; Pamela J. Bjorkman; Christopher Chiu; Elisa Nemes; Stephen B. Gordon; Andrew C. Steer; Thomas Rudel; Catherine A. Blish; John Tyler Sandberg; Kiva Brennan; Keith P. Klugman; Lynda M. Stuart; Shabir A. Madhi; Christopher L. Karp

doi:10.1111/nyas.14739

Innovative vaccine approaches-a Keystone Symposia report

Jennifer Cable (Lead / Corresponding author), Rino Rappuoli, Elizabeth J. Klemm, Gagandeep Kang, Ankur Mutreja, Gavin J. Wright, Mariagrazia Pizza, Sowmya Ajay Castro, Joseph P. Hoffmann, Galit Alter, Andrea Carfi, Andrew J. Pollard, Florian Krammer, Ravindra K. Gupta, Caroline E. Wagner, Viviane Machado, Kayvon Modjarrad, Lawrence Corey, Peter B. Gilbert, Gordon DouganNicole Lurie, Pamela J. Bjorkman, Christopher Chiu, Elisa Nemes, Stephen B. Gordon, Andrew C. Steer, Thomas Rudel, Catherine A. Blish, John Tyler Sandberg, Kiva Brennan, Keith P. Klugman, Lynda M. Stuart, Shabir A. Madhi, Christopher L. Karp

Molecular Microbiology

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The rapid development of COVID-19 vaccines was the result of decades of research to establish flexible vaccine platforms and understand pathogens with pandemic potential, as well as several novel changes to the vaccine discovery and development processes that partnered industry and governments. And while vaccines offer the potential to drastically improve global health, low-and-middle-income countries around the world often experience reduced access to vaccines and reduced vaccine efficacy. Addressing these issues will require novel vaccine approaches and platforms, deeper insight how vaccines mediate protection, and innovative trial designs and models. On June 28-30, 2021, experts in vaccine research, development, manufacturing, and deployment met virtually for the Keystone eSymposium "Innovative Vaccine Approaches" to discuss advances in vaccine research and development.

Original language	English
Pages (from-to)	59-86
Number of pages	28
Journal	Annals of the New York Academy of Sciences
Volume	1511
Issue number	1
Early online date	14 Jan 2022
DOIs	https://doi.org/10.1111/nyas.14739
Publication status	Published - 16 May 2022

Keywords

correlates of protection
COVID-19
human challenge studies
influenza
pneumococcal disease
streptococcus
vaccines
vaccine equity

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology
General Neuroscience
History and Philosophy of Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/nyas.14739

Cite this

Cable, J., Rappuoli, R., Klemm, E. J., Kang, G., Mutreja, A., Wright, G. J., Pizza, M., Castro, S. A., Hoffmann, J. P., Alter, G., Carfi, A., Pollard, A. J., Krammer, F., Gupta, R. K., Wagner, C. E., Machado, V., Modjarrad, K., Corey, L., Gilbert, P. B., ... Karp, C. L. (2022). Innovative vaccine approaches-a Keystone Symposia report. Annals of the New York Academy of Sciences, 1511(1), 59-86. https://doi.org/10.1111/nyas.14739

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title = "Innovative vaccine approaches-a Keystone Symposia report",

abstract = "The rapid development of COVID-19 vaccines was the result of decades of research to establish flexible vaccine platforms and understand pathogens with pandemic potential, as well as several novel changes to the vaccine discovery and development processes that partnered industry and governments. And while vaccines offer the potential to drastically improve global health, low-and-middle-income countries around the world often experience reduced access to vaccines and reduced vaccine efficacy. Addressing these issues will require novel vaccine approaches and platforms, deeper insight how vaccines mediate protection, and innovative trial designs and models. On June 28-30, 2021, experts in vaccine research, development, manufacturing, and deployment met virtually for the Keystone eSymposium {"}Innovative Vaccine Approaches{"} to discuss advances in vaccine research and development.",

keywords = "correlates of protection, COVID-19, human challenge studies, influenza, pneumococcal disease, streptococcus, vaccines, vaccine equity",

author = "Jennifer Cable and Rino Rappuoli and Klemm, {Elizabeth J.} and Gagandeep Kang and Ankur Mutreja and Wright, {Gavin J.} and Mariagrazia Pizza and Castro, {Sowmya Ajay} and Hoffmann, {Joseph P.} and Galit Alter and Andrea Carfi and Pollard, {Andrew J.} and Florian Krammer and Gupta, {Ravindra K.} and Wagner, {Caroline E.} and Viviane Machado and Kayvon Modjarrad and Lawrence Corey and Gilbert, {Peter B.} and Gordon Dougan and Nicole Lurie and Bjorkman, {Pamela J.} and Christopher Chiu and Elisa Nemes and Gordon, {Stephen B.} and Steer, {Andrew C.} and Thomas Rudel and Blish, {Catherine A.} and Sandberg, {John Tyler} and Kiva Brennan and Klugman, {Keith P.} and Stuart, {Lynda M.} and Madhi, {Shabir A.} and Karp, {Christopher L.}",

note = "{\textcopyright} 2022 New York Academy of Sciences.",

year = "2022",

month = may,

day = "16",

doi = "10.1111/nyas.14739",

language = "English",

volume = "1511",

pages = "59--86",

journal = "Annals of the New York Academy of Sciences",

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Cable, J, Rappuoli, R, Klemm, EJ, Kang, G, Mutreja, A, Wright, GJ, Pizza, M, Castro, SA, Hoffmann, JP, Alter, G, Carfi, A, Pollard, AJ, Krammer, F, Gupta, RK, Wagner, CE, Machado, V, Modjarrad, K, Corey, L, Gilbert, PB, Dougan, G, Lurie, N, Bjorkman, PJ, Chiu, C, Nemes, E, Gordon, SB, Steer, AC, Rudel, T, Blish, CA, Sandberg, JT, Brennan, K, Klugman, KP, Stuart, LM, Madhi, SA & Karp, CL 2022, 'Innovative vaccine approaches-a Keystone Symposia report', Annals of the New York Academy of Sciences, vol. 1511, no. 1, pp. 59-86. https://doi.org/10.1111/nyas.14739

TY - JOUR

T1 - Innovative vaccine approaches-a Keystone Symposia report

AU - Cable, Jennifer

AU - Rappuoli, Rino

AU - Klemm, Elizabeth J.

AU - Kang, Gagandeep

AU - Mutreja, Ankur

AU - Wright, Gavin J.

AU - Pizza, Mariagrazia

AU - Castro, Sowmya Ajay

AU - Hoffmann, Joseph P.

AU - Alter, Galit

AU - Carfi, Andrea

AU - Pollard, Andrew J.

AU - Krammer, Florian

AU - Gupta, Ravindra K.

AU - Wagner, Caroline E.

AU - Machado, Viviane

AU - Modjarrad, Kayvon

AU - Corey, Lawrence

AU - Gilbert, Peter B.

AU - Dougan, Gordon

AU - Lurie, Nicole

AU - Bjorkman, Pamela J.

AU - Chiu, Christopher

AU - Nemes, Elisa

AU - Gordon, Stephen B.

AU - Steer, Andrew C.

AU - Rudel, Thomas

AU - Blish, Catherine A.

AU - Sandberg, John Tyler

AU - Brennan, Kiva

AU - Klugman, Keith P.

AU - Stuart, Lynda M.

AU - Madhi, Shabir A.

AU - Karp, Christopher L.

PY - 2022/5/16

Y1 - 2022/5/16

N2 - The rapid development of COVID-19 vaccines was the result of decades of research to establish flexible vaccine platforms and understand pathogens with pandemic potential, as well as several novel changes to the vaccine discovery and development processes that partnered industry and governments. And while vaccines offer the potential to drastically improve global health, low-and-middle-income countries around the world often experience reduced access to vaccines and reduced vaccine efficacy. Addressing these issues will require novel vaccine approaches and platforms, deeper insight how vaccines mediate protection, and innovative trial designs and models. On June 28-30, 2021, experts in vaccine research, development, manufacturing, and deployment met virtually for the Keystone eSymposium "Innovative Vaccine Approaches" to discuss advances in vaccine research and development.

AB - The rapid development of COVID-19 vaccines was the result of decades of research to establish flexible vaccine platforms and understand pathogens with pandemic potential, as well as several novel changes to the vaccine discovery and development processes that partnered industry and governments. And while vaccines offer the potential to drastically improve global health, low-and-middle-income countries around the world often experience reduced access to vaccines and reduced vaccine efficacy. Addressing these issues will require novel vaccine approaches and platforms, deeper insight how vaccines mediate protection, and innovative trial designs and models. On June 28-30, 2021, experts in vaccine research, development, manufacturing, and deployment met virtually for the Keystone eSymposium "Innovative Vaccine Approaches" to discuss advances in vaccine research and development.

KW - correlates of protection

KW - COVID-19

KW - human challenge studies

KW - influenza

KW - pneumococcal disease

KW - streptococcus

KW - vaccines

KW - vaccine equity

UR - http://www.scopus.com/inward/record.url?scp=85130037278&partnerID=8YFLogxK

U2 - 10.1111/nyas.14739

DO - 10.1111/nyas.14739

M3 - Article

C2 - 35029310

SN - 0077-8923

VL - 1511

SP - 59

EP - 86

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

IS - 1

ER -

Innovative vaccine approaches-a Keystone Symposia report

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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