Insight from the air-skin interface

Ryan F. L. O'Shaughnessy; Sara J. Brown

doi:10.1038/jid.2014.457

Insight from the air-skin interface

Ryan F. L. O'Shaughnessy, Sara J. Brown (Lead / Corresponding author)

Research output: Contribution to journal › Comment/debate › peer-review

3 Citations (Scopus)

Abstract

The epidermis is a relatively hypoxic tissue, despite being continually exposed to air. The role of hypoxia in epidermal differentiation and skin barrier function is incompletely understood. In this issue, Wong et al. show that hypoxia-inducible factors are central to the processes of epidermal differentiation and barrier formation, in particular by promoting the expression of the key skin barrier protein filaggrin.

Original language	English
Pages (from-to)	331-333
Number of pages	3
Journal	Journal of Investigative Dermatology
Volume	135
Issue number	2
DOIs	https://doi.org/10.1038/jid.2014.457
Publication status	Published - Feb 2015

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10.1038/jid.2014.457

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1 Active

Molecular Mechanisms in Atopic Skin (Senior Research Fellowship in Clinical Science)
Brown, S.
Wellcome Trust
1/09/15 → 31/03/21
Project: Research

Cite this

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title = "Insight from the air-skin interface",

abstract = "The epidermis is a relatively hypoxic tissue, despite being continually exposed to air. The role of hypoxia in epidermal differentiation and skin barrier function is incompletely understood. In this issue, Wong et al. show that hypoxia-inducible factors are central to the processes of epidermal differentiation and barrier formation, in particular by promoting the expression of the key skin barrier protein filaggrin. ",

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AB - The epidermis is a relatively hypoxic tissue, despite being continually exposed to air. The role of hypoxia in epidermal differentiation and skin barrier function is incompletely understood. In this issue, Wong et al. show that hypoxia-inducible factors are central to the processes of epidermal differentiation and barrier formation, in particular by promoting the expression of the key skin barrier protein filaggrin.

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Insight from the air-skin interface

Abstract

Access to Document

Molecular Mechanisms in Atopic Skin (Senior Research Fellowship in Clinical Science)

Cite this