TY - JOUR
T1 - Insight from the air-skin interface
AU - O'Shaughnessy, Ryan F. L.
AU - Brown, Sara J.
PY - 2015/2
Y1 - 2015/2
N2 - The epidermis is a relatively hypoxic tissue, despite being continually exposed to air. The role of hypoxia in epidermal differentiation and skin barrier function is incompletely understood. In this issue, Wong et al. show that hypoxia-inducible factors are central to the processes of epidermal differentiation and barrier formation, in particular by promoting the expression of the key skin barrier protein filaggrin.
AB - The epidermis is a relatively hypoxic tissue, despite being continually exposed to air. The role of hypoxia in epidermal differentiation and skin barrier function is incompletely understood. In this issue, Wong et al. show that hypoxia-inducible factors are central to the processes of epidermal differentiation and barrier formation, in particular by promoting the expression of the key skin barrier protein filaggrin.
UR - http://www.scopus.com/inward/record.url?scp=84925366363&partnerID=8YFLogxK
U2 - 10.1038/jid.2014.457
DO - 10.1038/jid.2014.457
M3 - Comment/debate
C2 - 25573043
AN - SCOPUS:84925366363
VL - 135
SP - 331
EP - 333
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
SN - 0022-202X
IS - 2
ER -