Insight from the air-skin interface

Ryan F. L. O'Shaughnessy, Sara J. Brown (Lead / Corresponding author)

    Research output: Contribution to journalComment/debatepeer-review

    4 Citations (Scopus)


    The epidermis is a relatively hypoxic tissue, despite being continually exposed to air. The role of hypoxia in epidermal differentiation and skin barrier function is incompletely understood. In this issue, Wong et al. show that hypoxia-inducible factors are central to the processes of epidermal differentiation and barrier formation, in particular by promoting the expression of the key skin barrier protein filaggrin.

    Original languageEnglish
    Pages (from-to)331-333
    Number of pages3
    JournalJournal of Investigative Dermatology
    Issue number2
    Publication statusPublished - Feb 2015

    ASJC Scopus subject areas

    • General Medicine


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