Insight into the nature of the CRP-coronary event association using Mendelian randomization

Juan P. Casas, Tina Shah, Jackie Cooper, Emma Hawe, Alex D. McMahon, Dairena Gaffney, Christopher J Packard, Denis S O'Reilly, Irene Juhan-Vague, John S. Yudkin, Elena Tremoli, Maurizio Margaglione, Giovanni Di Minno, Anders Hamsten, Teake Kooistra, Jeffrey W Stephens, Steven J Hurel, Shona Livingstone, Helen M Colhoun, George J MillerLeonelo E Bautista, Tom Meade, Naveed Sattar, Steve E. Humphries, Aroon D. Hingorani

    Research output: Contribution to journalArticlepeer-review

    146 Citations (Scopus)

    Abstract

    It is unclear wheather the association between C-reactive protein (CRP) and incident coronary events is free from bias and confounding. Individuals homozygous for a +1444C>T polymorphism in the CRP gene have higher circulating concentrations of CRP. Since the distribution of this polymorphism occurs at random during gamete formation, its association with coronary events should not be biased or confounded.
    Original languageEnglish
    Pages (from-to)922-931
    Number of pages10
    JournalInternational Journal of Epidemiology
    Volume35
    Issue number4
    DOIs
    Publication statusPublished - 2006

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