Insight into the nature of the CRP-coronary event association using Mendelian randomization

Juan P. Casas; Tina Shah; Jackie Cooper; Emma Hawe; Alex D. McMahon; Dairena Gaffney; Christopher J Packard; Denis S O'Reilly; Irene Juhan-Vague; John S. Yudkin; Elena Tremoli; Maurizio Margaglione; Giovanni Di Minno; Anders Hamsten; Teake Kooistra; Jeffrey W Stephens; Steven J Hurel; Shona Livingstone; Helen M Colhoun; George J Miller; Leonelo E Bautista; Tom Meade; Naveed Sattar; Steve E. Humphries; Aroon D. Hingorani

doi:10.1093/ije/dyl041

Insight into the nature of the CRP-coronary event association using Mendelian randomization

Juan P. Casas, Tina Shah, Jackie Cooper, Emma Hawe, Alex D. McMahon, Dairena Gaffney, Christopher J Packard, Denis S O'Reilly, Irene Juhan-Vague, John S. Yudkin, Elena Tremoli, Maurizio Margaglione, Giovanni Di Minno, Anders Hamsten, Teake Kooistra, Jeffrey W Stephens, Steven J Hurel, Shona Livingstone, Helen M Colhoun, George J MillerLeonelo E Bautista, Tom Meade, Naveed Sattar, Steve E. Humphries, Aroon D. Hingorani

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159 Citations (Scopus)

Abstract

It is unclear wheather the association between C-reactive protein (CRP) and incident coronary events is free from bias and confounding. Individuals homozygous for a +1444C>T polymorphism in the CRP gene have higher circulating concentrations of CRP. Since the distribution of this polymorphism occurs at random during gamete formation, its association with coronary events should not be biased or confounded.

Original language	English
Pages (from-to)	922-931
Number of pages	10
Journal	International Journal of Epidemiology
Volume	35
Issue number	4
DOIs	https://doi.org/10.1093/ije/dyl041
Publication status	Published - 2006

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Casas, J. P., Shah, T., Cooper, J., Hawe, E., McMahon, A. D., Gaffney, D., Packard, C. J., O'Reilly, D. S., Juhan-Vague, I., Yudkin, J. S., Tremoli, E., Margaglione, M., Di Minno, G., Hamsten, A., Kooistra, T., Stephens, J. W., Hurel, S. J., Livingstone, S., Colhoun, H. M., ... Hingorani, A. D. (2006). Insight into the nature of the CRP-coronary event association using Mendelian randomization. International Journal of Epidemiology, 35(4), 922-931. https://doi.org/10.1093/ije/dyl041

@article{a87b0a0bfe894f039870f3b2305f1dff,

title = "Insight into the nature of the CRP-coronary event association using Mendelian randomization",

abstract = "It is unclear wheather the association between C-reactive protein (CRP) and incident coronary events is free from bias and confounding. Individuals homozygous for a +1444C>T polymorphism in the CRP gene have higher circulating concentrations of CRP. Since the distribution of this polymorphism occurs at random during gamete formation, its association with coronary events should not be biased or confounded.",

author = "Casas, {Juan P.} and Tina Shah and Jackie Cooper and Emma Hawe and McMahon, {Alex D.} and Dairena Gaffney and Packard, {Christopher J} and O'Reilly, {Denis S} and Irene Juhan-Vague and Yudkin, {John S.} and Elena Tremoli and Maurizio Margaglione and {Di Minno}, Giovanni and Anders Hamsten and Teake Kooistra and Stephens, {Jeffrey W} and Hurel, {Steven J} and Shona Livingstone and Colhoun, {Helen M} and Miller, {George J} and Bautista, {Leonelo E} and Tom Meade and Naveed Sattar and Humphries, {Steve E.} and Hingorani, {Aroon D.}",

year = "2006",

doi = "10.1093/ije/dyl041",

language = "English",

volume = "35",

pages = "922--931",

journal = "International Journal of Epidemiology",

issn = "0300-5771",

publisher = "Oxford University Press",

number = "4",

}

Casas, JP, Shah, T, Cooper, J, Hawe, E, McMahon, AD, Gaffney, D, Packard, CJ, O'Reilly, DS, Juhan-Vague, I, Yudkin, JS, Tremoli, E, Margaglione, M, Di Minno, G, Hamsten, A, Kooistra, T, Stephens, JW, Hurel, SJ, Livingstone, S, Colhoun, HM, Miller, GJ, Bautista, LE, Meade, T, Sattar, N, Humphries, SE & Hingorani, AD 2006, 'Insight into the nature of the CRP-coronary event association using Mendelian randomization', International Journal of Epidemiology, vol. 35, no. 4, pp. 922-931. https://doi.org/10.1093/ije/dyl041

TY - JOUR

T1 - Insight into the nature of the CRP-coronary event association using Mendelian randomization

AU - Casas, Juan P.

AU - Shah, Tina

AU - Cooper, Jackie

AU - Hawe, Emma

AU - McMahon, Alex D.

AU - Gaffney, Dairena

AU - Packard, Christopher J

AU - O'Reilly, Denis S

AU - Juhan-Vague, Irene

AU - Yudkin, John S.

AU - Tremoli, Elena

AU - Margaglione, Maurizio

AU - Di Minno, Giovanni

AU - Hamsten, Anders

AU - Kooistra, Teake

AU - Stephens, Jeffrey W

AU - Hurel, Steven J

AU - Livingstone, Shona

AU - Colhoun, Helen M

AU - Miller, George J

AU - Bautista, Leonelo E

AU - Meade, Tom

AU - Sattar, Naveed

AU - Humphries, Steve E.

AU - Hingorani, Aroon D.

PY - 2006

Y1 - 2006

N2 - It is unclear wheather the association between C-reactive protein (CRP) and incident coronary events is free from bias and confounding. Individuals homozygous for a +1444C>T polymorphism in the CRP gene have higher circulating concentrations of CRP. Since the distribution of this polymorphism occurs at random during gamete formation, its association with coronary events should not be biased or confounded.

AB - It is unclear wheather the association between C-reactive protein (CRP) and incident coronary events is free from bias and confounding. Individuals homozygous for a +1444C>T polymorphism in the CRP gene have higher circulating concentrations of CRP. Since the distribution of this polymorphism occurs at random during gamete formation, its association with coronary events should not be biased or confounded.

U2 - 10.1093/ije/dyl041

DO - 10.1093/ije/dyl041

M3 - Article

C2 - 16565153

SN - 0300-5771

VL - 35

SP - 922

EP - 931

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

IS - 4

ER -

Insight into the nature of the CRP-coronary event association using Mendelian randomization

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