Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats

D. Spanswick; M. A. Smith; S. Mirshamsi; V. H. Routh; M. L. J. Ashford

doi:10.1038/77660

Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats

D. Spanswick, M. A. Smith, S. Mirshamsi, V. H. Routh, M. L. J. Ashford

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Abstract

Insulin and leptin receptors are present in hypothalamic regions that control energy homeostasis, and these hormones reduce food intake and body weight in lean, but not obese, Zucker rats. Here we demonstrate that insulin, like leptin, hyperpolarizes lean rat hypothalamic glucose-responsive (GR) neurons by opening KATP channels. These findings suggest hypothalamic K ATP channel function is crucial to physiological regulation of food intake and body weight.

Original language	English
Pages (from-to)	757-758
Number of pages	2
Journal	Nature Neuroscience
Volume	3
Issue number	8
DOIs	https://doi.org/10.1038/77660
Publication status	Published - 2000

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abstract = "Insulin and leptin receptors are present in hypothalamic regions that control energy homeostasis, and these hormones reduce food intake and body weight in lean, but not obese, Zucker rats. Here we demonstrate that insulin, like leptin, hyperpolarizes lean rat hypothalamic glucose-responsive (GR) neurons by opening KATP channels. These findings suggest hypothalamic K ATP channel function is crucial to physiological regulation of food intake and body weight.",

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AU - Ashford, M. L. J.

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AB - Insulin and leptin receptors are present in hypothalamic regions that control energy homeostasis, and these hormones reduce food intake and body weight in lean, but not obese, Zucker rats. Here we demonstrate that insulin, like leptin, hyperpolarizes lean rat hypothalamic glucose-responsive (GR) neurons by opening KATP channels. These findings suggest hypothalamic K ATP channel function is crucial to physiological regulation of food intake and body weight.

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DO - 10.1038/77660

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JF - Nature Neuroscience

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Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats

Abstract

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