Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats

D. Spanswick, M. A. Smith, S. Mirshamsi, V. H. Routh, M. L. J. Ashford

    Research output: Contribution to journalArticlepeer-review

    413 Citations (Scopus)

    Abstract

    Insulin and leptin receptors are present in hypothalamic regions that control energy homeostasis, and these hormones reduce food intake and body weight in lean, but not obese, Zucker rats. Here we demonstrate that insulin, like leptin, hyperpolarizes lean rat hypothalamic glucose-responsive (GR) neurons by opening KATP channels. These findings suggest hypothalamic K ATP channel function is crucial to physiological regulation of food intake and body weight.
    Original languageEnglish
    Pages (from-to)757-758
    Number of pages2
    JournalNature Neuroscience
    Volume3
    Issue number8
    DOIs
    Publication statusPublished - 2000

    Fingerprint Dive into the research topics of 'Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats'. Together they form a unique fingerprint.

    Cite this