Integrating cell-signalling pathways with NF-κB and IKK function

Nuclear factor (NF)-?B and inhibitor of NF-?B kinase (IKK) proteins regulate many physiological processes, including the innate- and adaptive-immune responses, cell death and inflammation. Disruption of NF-?B or IKK function contributes to many human diseases, including cancer. However, the NF-?B and IKK pathways do not exist in isolation and there are many mechanisms that integrate their activity with other cell-signalling networks. This crosstalk constitutes a decision-making process that determines the consequences of NF-?B and IKK activation and, ultimately, cell fate.