Integrating cell-signalling pathways with NF-κB and IKK function

Neil D. Perkins

    Research output: Contribution to journalArticle

    1701 Citations (Scopus)

    Abstract

    Nuclear factor (NF)-?B and inhibitor of NF-?B kinase (IKK) proteins regulate many physiological processes, including the innate- and adaptive-immune responses, cell death and inflammation. Disruption of NF-?B or IKK function contributes to many human diseases, including cancer. However, the NF-?B and IKK pathways do not exist in isolation and there are many mechanisms that integrate their activity with other cell-signalling networks. This crosstalk constitutes a decision-making process that determines the consequences of NF-?B and IKK activation and, ultimately, cell fate.
    Original languageEnglish
    Pages (from-to)49-62
    Number of pages14
    JournalNature Reviews Molecular Cell Biology
    Volume8
    Issue number1
    DOIs
    Publication statusPublished - Jan 2007

    Keywords

    • Animals
    • Enzyme Activation
    • Humans
    • I-kappa B Kinase
    • I-kappa B Proteins
    • NF-kappa B
    • Protein Subunits
    • Signal Transduction

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