Intelligent Liver Function Testing (iLFT): An Intelligent Laboratory Approach to Identifying Chronic Liver Disease

Jennifer Nobes, Damien Leith, Sava Handjiev, John F. Dillon, Ellie Dow (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

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Abstract

The intelligent Liver Function Testing (iLFT) pathway is a novel, algorithm-based system which provides automated laboratory investigations and clinical feedback on abnormal liver function test (LFT) results from primary care. iLFT was introduced to NHS Tayside, Scotland, in August 2018 in response to vast numbers of abnormal LFTs, many of which were not appropriately investigated, coupled with rising mortality from chronic liver disease. Here, we outline the development and implementation of the iLFT pathway, considering the implications for the diagnostic laboratories, primary care services and specialist hepatology clinics. Additionally, we describe the utility, outcomes and evolution of iLFT, which was used over 11,000 times in its first three years alone. Finally, we will consider the future of iLFT and propose areas where similar ‘intelligent’ approaches could be used to add value to laboratory investigations.

Original languageEnglish
Article number960
Number of pages15
JournalDiagnostics
Volume14
Issue number9
DOIs
Publication statusPublished - 4 May 2024

Keywords

  • algorithm
  • automation
  • chronic liver disease
  • diagnosis
  • fibrosis
  • intelligent
  • laboratory
  • liver function tests
  • management
  • precision medicine
  • referral

ASJC Scopus subject areas

  • Clinical Biochemistry

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