Interdisciplinary Perspectives on the Co-Management of Metabolic Dysfunction-Associated Steatotic Liver Disease and Coronary Artery Disease

Jacob J. Gries, Jeffrey V. Lazarus, Paul Brennan, Mohammad S. Siddiqui, Giovanni Targher, Chim Lang, Salim S. Virani, Carl J. Lavie, Scott Isaacs, Juan Pablo Arab, Kenneth Cusi, Chayakrit Krittanawong (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as a public health threat as it affects approximately 38% of the adult population worldwide, with its prevalence rising in step with that of obesity and type 2 diabetes (T2D). Beyond its liver health implications, MASLD is associated with cardiovascular and vascular dysfunction. Although the many shared risk factors and common metabolic milieu may indicate that cardiovascular disease and MASLD are discrete outcomes from common systemic pathogeneses, a growing body of evidence has identified a potential causal relationship between MASLD and coronary artery disease (CAD), which is the leading cause of morbidity and mortality in people with MASLD and all-cause mortality worldwide. This narrative review takes an interdisciplinary approach, drawing on hepatology, cardiology, endocrinology, and metabolic and internal medicine specialists to help delineate the intricate interplay between MASLD and CAD. It sheds light on novel opportunities for targeted interventions and personalized management strategies.
Original languageEnglish
Pages (from-to)82-94
Number of pages13
JournalThe Lancet Gastroenterology and Hepatology
Volume10
Issue number1
Early online date11 Dec 2024
DOIs
Publication statusPublished - Jan 2025

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