Interethnic analyses of blood pressure loci in populations of East Asian and European descent

Fumihiko Takeuchi; Masato Akiyama; Nana Matoba; Tomohiro Katsuya; Masahiro Nakatochi; Yasuharu Tabara; Akira Narita; Woei Yuh Saw; Sanghoon Moon; Cassandra N. Spracklen; Jin Fang Chai; Young Jin Kim; Liang Zhang; Chaolong Wang; Huaixing Li; Honglan Li; Jer Yuarn Wu; Rajkumar Dorajoo; Jovia L. Nierenberg; Ya Xing Wang; Jing He; Derrick A. Bennett; Atsushi Takahashi; Yukihide Momozawa; Makoto Hirata; Koichi Matsuda; Hiromi Rakugi; Eitaro Nakashima; Masato Isono; Matsuyuki Shirota; Atsushi Hozawa; Sahoko Ichihara; Tatsuaki Matsubara; Ken Yamamoto; Katsuhiko Kohara; Michiya Igase; Sohee Han; Penny Gordon-Larsen; Wei Huang; Nanette R. Lee; Linda S. Adair; Mi Yeong Hwang; Juyoung Lee; Miao Li Chee; Charumathi Sabanayagam; Wanting Zhao; Jianjun Liu; Dermot F. Reilly; Liang Sun; Shaofeng Huo; Todd L. Edwards; Jirong Long; Li-Ching Chang; Chien-Hsiun  Chen; Jian-Min Yuan; Woon-Puay Koh; Yechiel Friedlander; Tanika N. Kelly; Wen Bin Wei; Liang Xu; Hui  Cai; Yong-Bing Xiang; Kuang Lin; Robert Clarke; Robin G Walters; Iona Y. Millwood; Liming Li; John C. Chambers; Paul Elliott; Pim van der Harst; The International Genomics of Blood Pressure (iGEN-BP) Consortium; James Abbott; Zhengming Chen; Makoto Sasaki; Xiao Ou Shu; Jost B. Jonas; Jiang He; Chew-Kiat Heng; Yuan-Tsong Chen; Wei Zheng; Xu Lin; Yik-Ying Teo; E. Shyong  Tai; Ching-Yu Cheng; Tien-Yin Wong; Xueling Sim; Karen L. Mohlke; Masayuki Yamamoto; Bong-Jo Kim; Tetsuro Miki; Toru Nabika; Mitsuhiro Yokota; Yoichiro Kamatani; Michiaki Kubo; Norihiro Kato

doi:10.1038/s41467-018-07345-0

Interethnic analyses of blood pressure loci in populations of East Asian and European descent

Fumihiko Takeuchi
, Masato Akiyama
, Nana Matoba
, Tomohiro Katsuya
, Masahiro Nakatochi
, Yasuharu Tabara
, Akira Narita
, Woei Yuh Saw
, Sanghoon Moon
, Cassandra N. Spracklen
, Jin Fang Chai
, Young Jin Kim
, Liang Zhang
, Chaolong Wang
, Huaixing Li
, Honglan Li
, Jer Yuarn Wu
, Rajkumar Dorajoo
, Jovia L. Nierenberg
, Ya Xing Wang

Jing He, Derrick A. Bennett, Atsushi Takahashi, Yukihide Momozawa, Makoto Hirata, Koichi Matsuda, Hiromi Rakugi, Eitaro Nakashima, Masato Isono, Matsuyuki Shirota, Atsushi Hozawa, Sahoko Ichihara, Tatsuaki Matsubara, Ken Yamamoto, Katsuhiko Kohara, Michiya Igase, Sohee Han, Penny Gordon-Larsen, Wei Huang, Nanette R. Lee, Linda S. Adair, Mi Yeong Hwang, Juyoung Lee, Miao Li Chee, Charumathi Sabanayagam, Wanting Zhao, Jianjun Liu, Dermot F. Reilly, Liang Sun, Shaofeng Huo, Todd L. Edwards, Jirong Long, Li-Ching Chang, Chien-Hsiun Chen, Jian-Min Yuan, Woon-Puay Koh, Yechiel Friedlander, Tanika N. Kelly, Wen Bin Wei, Liang Xu, Hui Cai, Yong-Bing Xiang, Kuang Lin, Robert Clarke, Robin G Walters, Iona Y. Millwood, Liming Li, John C. Chambers, Paul Elliott, Pim van der Harst, The International Genomics of Blood Pressure (iGEN-BP) Consortium, James Abbott (Research group member), Zhengming Chen, Makoto Sasaki, Xiao Ou Shu, Jost B. Jonas, Jiang He, Chew-Kiat Heng, Yuan-Tsong Chen, Wei Zheng, Xu Lin, Yik-Ying Teo, E. Shyong Tai, Ching-Yu Cheng, Tien-Yin Wong, Xueling Sim, Karen L. Mohlke, Masayuki Yamamoto, Bong-Jo Kim, Tetsuro Miki, Toru Nabika, Mitsuhiro Yokota, Yoichiro Kamatani, Michiaki Kubo, Norihiro Kato (Lead / Corresponding author)

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Abstract

Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.

Original language	English
Article number	5052
Number of pages	16
Journal	Nature Communications
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41467-018-07345-0
Publication status	Published - 28 Nov 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

General Chemistry
General Biochemistry,Genetics and Molecular Biology
General
General Physics and Astronomy

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Final published versionFinal published version, 1.9 MBLicence: CC BY

Cite this

Takeuchi, F., Akiyama, M., Matoba, N., Katsuya, T., Nakatochi, M., Tabara, Y., Narita, A., Saw, W. Y., Moon, S., Spracklen, C. N., Chai, J. F., Kim, Y. J., Zhang, L., Wang, C., Li, H., Li, H., Wu, J. Y., Dorajoo, R., Nierenberg, J. L., ... Kato, N. (2018). Interethnic analyses of blood pressure loci in populations of East Asian and European descent. Nature Communications, 9(1), Article 5052. https://doi.org/10.1038/s41467-018-07345-0

@article{9478b8abc725471e8dc296357d583ab0,

title = "Interethnic analyses of blood pressure loci in populations of East Asian and European descent",

abstract = "Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.",

author = "Fumihiko Takeuchi and Masato Akiyama and Nana Matoba and Tomohiro Katsuya and Masahiro Nakatochi and Yasuharu Tabara and Akira Narita and Saw, \{Woei Yuh\} and Sanghoon Moon and Spracklen, \{Cassandra N.\} and Chai, \{Jin Fang\} and Kim, \{Young Jin\} and Liang Zhang and Chaolong Wang and Huaixing Li and Honglan Li and Wu, \{Jer Yuarn\} and Rajkumar Dorajoo and Nierenberg, \{Jovia L.\} and Wang, \{Ya Xing\} and Jing He and Bennett, \{Derrick A.\} and Atsushi Takahashi and Yukihide Momozawa and Makoto Hirata and Koichi Matsuda and Hiromi Rakugi and Eitaro Nakashima and Masato Isono and Matsuyuki Shirota and Atsushi Hozawa and Sahoko Ichihara and Tatsuaki Matsubara and Ken Yamamoto and Katsuhiko Kohara and Michiya Igase and Sohee Han and Penny Gordon-Larsen and Wei Huang and Lee, \{Nanette R.\} and Adair, \{Linda S.\} and Hwang, \{Mi Yeong\} and Juyoung Lee and Chee, \{Miao Li\} and Charumathi Sabanayagam and Wanting Zhao and Jianjun Liu and Reilly, \{Dermot F.\} and Liang Sun and Shaofeng Huo and Edwards, \{Todd L.\} and Jirong Long and Li-Ching Chang and Chien-Hsiun Chen and Jian-Min Yuan and Woon-Puay Koh and Yechiel Friedlander and Kelly, \{Tanika N.\} and Wei, \{Wen Bin\} and Liang Xu and Hui Cai and Yong-Bing Xiang and Kuang Lin and Robert Clarke and Walters, \{Robin G\} and Millwood, \{Iona Y.\} and Liming Li and Chambers, \{John C.\} and Paul Elliott and \{van der Harst\}, Pim and \{The International Genomics of Blood Pressure (iGEN-BP) Consortium\} and James Abbott and Zhengming Chen and Makoto Sasaki and Shu, \{Xiao Ou\} and Jonas, \{Jost B.\} and Jiang He and Chew-Kiat Heng and Yuan-Tsong Chen and Wei Zheng and Xu Lin and Yik-Ying Teo and Tai, \{E. Shyong\} and Ching-Yu Cheng and Tien-Yin Wong and Xueling Sim and Mohlke, \{Karen L.\} and Masayuki Yamamoto and Bong-Jo Kim and Tetsuro Miki and Toru Nabika and Mitsuhiro Yokota and Yoichiro Kamatani and Michiaki Kubo and Norihiro Kato",

note = "Publisher Copyright: {\textcopyright} 2018, The Author(s).",

year = "2018",

month = nov,

day = "28",

doi = "10.1038/s41467-018-07345-0",

language = "English",

volume = "9",

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Takeuchi, F, Akiyama, M, Matoba, N, Katsuya, T, Nakatochi, M, Tabara, Y, Narita, A, Saw, WY, Moon, S, Spracklen, CN, Chai, JF, Kim, YJ, Zhang, L, Wang, C, Li, H, Li, H, Wu, JY, Dorajoo, R, Nierenberg, JL, Wang, YX, He, J, Bennett, DA, Takahashi, A, Momozawa, Y, Hirata, M, Matsuda, K, Rakugi, H, Nakashima, E, Isono, M, Shirota, M, Hozawa, A, Ichihara, S, Matsubara, T, Yamamoto, K, Kohara, K, Igase, M, Han, S, Gordon-Larsen, P, Huang, W, Lee, NR, Adair, LS, Hwang, MY, Lee, J, Chee, ML, Sabanayagam, C, Zhao, W, Liu, J, Reilly, DF, Sun, L, Huo, S, Edwards, TL, Long, J, Chang, L-C, Chen, C-H, Yuan, J-M, Koh, W-P, Friedlander, Y, Kelly, TN, Wei, WB, Xu, L, Cai, H, Xiang, Y-B, Lin, K, Clarke, R, Walters, RG, Millwood, IY, Li, L, Chambers, JC, Elliott, P, van der Harst, P, The International Genomics of Blood Pressure (iGEN-BP) Consortium, Abbott, J, Chen, Z, Sasaki, M, Shu, XO, Jonas, JB, He, J, Heng, C-K, Chen, Y-T, Zheng, W, Lin, X, Teo, Y-Y, Tai, ES, Cheng, C-Y, Wong, T-Y, Sim, X, Mohlke, KL, Yamamoto, M, Kim, B-J, Miki, T, Nabika, T, Yokota, M, Kamatani, Y, Kubo, M & Kato, N 2018, 'Interethnic analyses of blood pressure loci in populations of East Asian and European descent', Nature Communications, vol. 9, no. 1, 5052. https://doi.org/10.1038/s41467-018-07345-0

TY - JOUR

T1 - Interethnic analyses of blood pressure loci in populations of East Asian and European descent

AU - Takeuchi, Fumihiko

AU - Akiyama, Masato

AU - Matoba, Nana

AU - Katsuya, Tomohiro

AU - Nakatochi, Masahiro

AU - Tabara, Yasuharu

AU - Narita, Akira

AU - Saw, Woei Yuh

AU - Moon, Sanghoon

AU - Spracklen, Cassandra N.

AU - Chai, Jin Fang

AU - Kim, Young Jin

AU - Zhang, Liang

AU - Wang, Chaolong

AU - Li, Huaixing

AU - Li, Honglan

AU - Wu, Jer Yuarn

AU - Dorajoo, Rajkumar

AU - Nierenberg, Jovia L.

AU - Wang, Ya Xing

AU - He, Jing

AU - Bennett, Derrick A.

AU - Takahashi, Atsushi

AU - Momozawa, Yukihide

AU - Hirata, Makoto

AU - Matsuda, Koichi

AU - Rakugi, Hiromi

AU - Nakashima, Eitaro

AU - Isono, Masato

AU - Shirota, Matsuyuki

AU - Hozawa, Atsushi

AU - Ichihara, Sahoko

AU - Matsubara, Tatsuaki

AU - Yamamoto, Ken

AU - Kohara, Katsuhiko

AU - Igase, Michiya

AU - Han, Sohee

AU - Gordon-Larsen, Penny

AU - Huang, Wei

AU - Lee, Nanette R.

AU - Adair, Linda S.

AU - Hwang, Mi Yeong

AU - Lee, Juyoung

AU - Chee, Miao Li

AU - Sabanayagam, Charumathi

AU - Zhao, Wanting

AU - Liu, Jianjun

AU - Reilly, Dermot F.

AU - Sun, Liang

AU - Huo, Shaofeng

AU - Edwards, Todd L.

AU - Long, Jirong

AU - Chang, Li-Ching

AU - Chen, Chien-Hsiun

AU - Yuan, Jian-Min

AU - Koh, Woon-Puay

AU - Friedlander, Yechiel

AU - Kelly, Tanika N.

AU - Wei, Wen Bin

AU - Xu, Liang

AU - Cai, Hui

AU - Xiang, Yong-Bing

AU - Lin, Kuang

AU - Clarke, Robert

AU - Walters, Robin G

AU - Millwood, Iona Y.

AU - Li, Liming

AU - Chambers, John C.

AU - Elliott, Paul

AU - van der Harst, Pim

AU - The International Genomics of Blood Pressure (iGEN-BP) Consortium

AU - Chen, Zhengming

AU - Sasaki, Makoto

AU - Shu, Xiao Ou

AU - Jonas, Jost B.

AU - He, Jiang

AU - Heng, Chew-Kiat

AU - Chen, Yuan-Tsong

AU - Zheng, Wei

AU - Lin, Xu

AU - Teo, Yik-Ying

AU - Tai, E. Shyong

AU - Cheng, Ching-Yu

AU - Wong, Tien-Yin

AU - Sim, Xueling

AU - Mohlke, Karen L.

AU - Yamamoto, Masayuki

AU - Kim, Bong-Jo

AU - Miki, Tetsuro

AU - Nabika, Toru

AU - Yokota, Mitsuhiro

AU - Kamatani, Yoichiro

AU - Kubo, Michiaki

AU - Kato, Norihiro

A2 - Abbott, James

PY - 2018/11/28

Y1 - 2018/11/28

N2 - Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.

AB - Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.

U2 - 10.1038/s41467-018-07345-0

DO - 10.1038/s41467-018-07345-0

M3 - Article

C2 - 30487518

SN - 2041-1723

VL - 9

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 5052

ER -

Interethnic analyses of blood pressure loci in populations of East Asian and European descent

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