Interfering with Wnt signalling alters the periodicity of the segmentation clock

Sarah Gibb, Anna Zagorska, Kristin Melton, Gennady Tenin, Irene Vacca, Paul Trainor, Miguel Maroto, J. Kim Dale

    Research output: Contribution to journalArticlepeer-review

    52 Citations (Scopus)


    Somites are embryonic precursors of the ribs, vertebrae and certain dermis tissue. Somite formation is a periodic process regulated by a molecular clock which drives cyclic expression of a number of clock genes in the presomitic mesoderm. To date the mechanism regulating the period of clock gene oscillations is unknown. Here we show that chick homologues of the Wnt pathway genes that oscillate in mouse do not cycle across the chick presomitic mesoderm. Strikingly we find that modifying Wnt signalling changes the period of Notch driven oscillations in both mouse and chick but these oscillations continue. We propose that the Wnt pathway is a conserved mechanism that is involved in regulating the period of cyclic gene oscillations in the presomitic mesoderm. (C) 2009 Elsevier Inc. All rights reserved.

    Original languageEnglish
    Pages (from-to)21-31
    Number of pages11
    JournalDevelopmental Biology
    Issue number1
    Publication statusPublished - 1 Jun 2009


    • Notch
    • Wnt
    • Embryo
    • Mouse
    • Chick
    • Somite
    • Segmentation clock
    • Casein kinase-I
    • Somite segmentation
    • Gene expression
    • Lunatic fringe
    • Vertebrate segmentation
    • Chick embryo
    • Somitogenesis
    • FGF
    • Oscillations


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