Interferon treatment suppresses enteric adenovirus infection in a model gastrointestinal cell-culture system

Victoria Sherwood, Elizabeth King, Sabine Tötemeyer, Ian Connerton, Kenneth H. Mellits (Lead / Corresponding author)

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    Exposure to interferon results in the rapid transcriptional induction of genes, many of which function to create an antiviral environment in potential host cells. For the majority of adenoviruses, replication is unaffected by the actions of interferon. It has previously been shown, using non-gastrointestinal cells, that the species F human adenoviruses are sensitive to the action of interferon. Here, we have developed an enterocyte-like cell-culture model to re-evaluate this question, and determined the effects of interferon on species F adenovirus during infection of gastrointestinal cells. We show that species F adenovirus type 40 is sensitive to the effects of interferon in gastrointestinal-like cells, which may help to explain its fastidious growth in culture.

    Original languageEnglish
    Pages (from-to)618-623
    Number of pages6
    JournalJournal of General Virology
    Volume93
    Issue number3
    Early online date1 Mar 2012
    DOIs
    Publication statusPublished - Mar 2012

    Keywords

    • Adenoviridae
    • Adenovirus infections, Human
    • Antiviral agents
    • Cell culture techniques
    • Chemoprevention
    • Gastrointestinal tract
    • Humans
    • Interferons
    • Models, Theoretical

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