Interim Analysis of MEDICI: Mammographic Predictors of Cancer Recurrence after Breast Conservation and Adjuvant Endocrine Therapy

Sarah Savaridas (Lead / Corresponding author), Andrew Marshall, Sarah Vinnicombe, Mark Halling-Brown, Kulsam Ali, Patsy Whelehan, Andrew Evans, Sue Astley, Nuala Healy, Ashwini Sharma, Sonya Drummond, Jonathon Nash, Sreenivas Muthyala, Elizabeth Muscat, Marianna Telesca, Janet Dunn

Research output: Contribution to conferencePaperpeer-review

Abstract

Background: Mammographic density (MD) is a well-established breast cancer risk factor. Decreasing MD has been demonstrated to be a risk-reduction biomarker in a landmark chemoprevention study in high-risk women. A few small studies suggest that a decreasing MD in women taking adjuvant endocrine therapy (AET) may be associated with a lower risk of recurrence and breast cancer specific death.

Aim: This interim analysis aims to measure inter and intra-reader variability of MD classification within a current study (MEDICI) investigating whether a reduction in MD after one and/or three years in women taking AET is associated with a lower risk of breast cancer recurrence and death compared to no reduction.

Methods: Retrospective cohort study, generated from a subset of participants from the Mammo-50 trial. Eleven readers assessed MD using a 0 to 100% visual analogue scale (VAS), scoring mammograms from time of diagnosis and at one and three years after diagnosis. A subset of four readers re-analysed the mammograms. Inter and intra- reader agreement were estimated using intra-class correlation coefficients (ICC).

Results: Eleven readers classified MD in 50 patients at three timepoints (150 mammograms), using the VAS. Four readers re-interpreted all 150 mammograms. The ICC between all 11 readers (inter-reader agreement) was 0.80 (95% confidence interval (CI): 0.77-0.84). The ICC within readers (intra-reader agreement) was 0.86 (95% CI 0.77-0.91).

Conclusion: Interim analysis demonstrates good inter- and intra-reader agreement for assessment of MD on VAS, suggesting validity of the human MD assessment to be performed within the MEDICI study.
Original languageEnglish
Publication statusPublished - Nov 2024
EventBritish Society of Breast Radiology Annual Scientific Meeting 2024 - Hilton Hotel, Liverpool, United Kingdom
Duration: 3 Nov 20245 Nov 2024
https://www.delegate-reg.co.uk/bsbr2024/

Conference

ConferenceBritish Society of Breast Radiology Annual Scientific Meeting 2024
Abbreviated titleBSBR 2024
Country/TerritoryUnited Kingdom
CityLiverpool
Period3/11/245/11/24
Internet address

Fingerprint

Dive into the research topics of 'Interim Analysis of MEDICI: Mammographic Predictors of Cancer Recurrence after Breast Conservation and Adjuvant Endocrine Therapy'. Together they form a unique fingerprint.

Cite this