Interleukin-33 in the developing lung—Roles in asthma and infection

Kristina Johansson, Henry J. McSorley (Lead / Corresponding author)

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

It has become increasingly clear that interleukin-33 (IL-33) plays a crucial role in initiation of type 2 immunity. The last decade of intense research has uncovered multiple mechanisms through which IL-33 targets key effector cells of the allergic immune response. Recently, IL-33 has been implicated in shaping the immune system of the lungs early in life, at a time which is crucial in the subsequent development of allergic asthma. In this review, we will address the current literature describing the role of IL-33 in the healthy and diseased lung. In particular, we will focus on the evidence for IL-33 in the development of immune responses in the lung, including the role of IL-33–responsive immune cells that may explain susceptibility to allergic sensitization at a young age and the association between genetic variants of IL-33 and asthma in humans. Finally, we will indicate areas for potential therapeutic modulation of the IL-33 pathway.

Original languageEnglish
Pages (from-to)503-510
Number of pages8
JournalPediatric Allergy and Immunology
Volume30
Issue number5
Early online date7 Feb 2019
DOIs
Publication statusPublished - Aug 2019

Keywords

  • airborne viruses
  • development of asthma
  • early intervention
  • immune mechanisms
  • respiratory epithelium

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