Interleukin-8 (IL-8) may contribute to the activation of neutrophils in patients with peripheral arterial occlusive disease (PAOD)

G. Kirk, P. Hickman, M. McLaren, P. A. Stonebridge, J. J. F. Belch

    Research output: Contribution to journalArticle

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    Abstract

    Objectives: to investigate the levels of interleukin-8 (IL-8) in patients with peripheral arterial occlusive disease (PAOD) and healthy control subjects both before and after an acute exercise test. Materials and methods: twenty-six patients with intermittent claudication and 22 matched healthy control subjects each had IL-8 levels measured before and after a standard acute treadmill-exercise test. Subjects walked for 10 min or until stopped by claudication pain. Serum IL-8 levels were measured before exercise was commenced and 1, 5 and 10 min after exercise was stopped.Results: patients with PAOD had statistically significantly higher levels of IL-8 than healthy control subjects, before and after an acute exercise test (p <0.00001, Mann–Whitney). Ratios of the change of IL-8 levels post-exercise showed a statistically significant difference at the post-5-min time point (/E2>p =0.005), showing a difference in the change of IL-8 levels at this time point between the patient group and control group. Conclusions: The increased levels and the failure of the cytokine levels to fall by the same extent after exercise in the patient group may be due to a combination of increased neutrophil activation, reduced blood flow and increased cytokine production during ischaemia–reperfusion, which is not observed in the healthy controls.
    Original languageEnglish
    Pages (from-to)434-438
    Number of pages5
    JournalEuropean Journal of Vascular and Endovascular Surgery
    Volume18
    Issue number5
    DOIs
    Publication statusPublished - 1999

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    Arterial Occlusive Diseases
    Neutrophil Activation
    Peripheral Arterial Disease
    Interleukin-8
    Exercise
    Exercise Test
    Healthy Volunteers
    Cytokines
    Intermittent Claudication
    Pain
    Control Groups
    Serum

    Cite this

    @article{1655f417c219460eb2dc6cde2c60394d,
    title = "Interleukin-8 (IL-8) may contribute to the activation of neutrophils in patients with peripheral arterial occlusive disease (PAOD)",
    abstract = "Objectives: to investigate the levels of interleukin-8 (IL-8) in patients with peripheral arterial occlusive disease (PAOD) and healthy control subjects both before and after an acute exercise test. Materials and methods: twenty-six patients with intermittent claudication and 22 matched healthy control subjects each had IL-8 levels measured before and after a standard acute treadmill-exercise test. Subjects walked for 10 min or until stopped by claudication pain. Serum IL-8 levels were measured before exercise was commenced and 1, 5 and 10 min after exercise was stopped.Results: patients with PAOD had statistically significantly higher levels of IL-8 than healthy control subjects, before and after an acute exercise test (p <0.00001, Mann–Whitney). Ratios of the change of IL-8 levels post-exercise showed a statistically significant difference at the post-5-min time point (/E2>p =0.005), showing a difference in the change of IL-8 levels at this time point between the patient group and control group. Conclusions: The increased levels and the failure of the cytokine levels to fall by the same extent after exercise in the patient group may be due to a combination of increased neutrophil activation, reduced blood flow and increased cytokine production during ischaemia–reperfusion, which is not observed in the healthy controls.",
    author = "G. Kirk and P. Hickman and M. McLaren and Stonebridge, {P. A.} and Belch, {J. J. F.}",
    note = "Copyright 1999 Harcourt Publishers Ltd.",
    year = "1999",
    doi = "10.1053/ejvs.1999.0927",
    language = "English",
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    pages = "434--438",
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    Interleukin-8 (IL-8) may contribute to the activation of neutrophils in patients with peripheral arterial occlusive disease (PAOD). / Kirk, G.; Hickman, P.; McLaren, M.; Stonebridge, P. A.; Belch, J. J. F.

    In: European Journal of Vascular and Endovascular Surgery, Vol. 18, No. 5, 1999, p. 434-438.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Interleukin-8 (IL-8) may contribute to the activation of neutrophils in patients with peripheral arterial occlusive disease (PAOD)

    AU - Kirk, G.

    AU - Hickman, P.

    AU - McLaren, M.

    AU - Stonebridge, P. A.

    AU - Belch, J. J. F.

    N1 - Copyright 1999 Harcourt Publishers Ltd.

    PY - 1999

    Y1 - 1999

    N2 - Objectives: to investigate the levels of interleukin-8 (IL-8) in patients with peripheral arterial occlusive disease (PAOD) and healthy control subjects both before and after an acute exercise test. Materials and methods: twenty-six patients with intermittent claudication and 22 matched healthy control subjects each had IL-8 levels measured before and after a standard acute treadmill-exercise test. Subjects walked for 10 min or until stopped by claudication pain. Serum IL-8 levels were measured before exercise was commenced and 1, 5 and 10 min after exercise was stopped.Results: patients with PAOD had statistically significantly higher levels of IL-8 than healthy control subjects, before and after an acute exercise test (p <0.00001, Mann–Whitney). Ratios of the change of IL-8 levels post-exercise showed a statistically significant difference at the post-5-min time point (/E2>p =0.005), showing a difference in the change of IL-8 levels at this time point between the patient group and control group. Conclusions: The increased levels and the failure of the cytokine levels to fall by the same extent after exercise in the patient group may be due to a combination of increased neutrophil activation, reduced blood flow and increased cytokine production during ischaemia–reperfusion, which is not observed in the healthy controls.

    AB - Objectives: to investigate the levels of interleukin-8 (IL-8) in patients with peripheral arterial occlusive disease (PAOD) and healthy control subjects both before and after an acute exercise test. Materials and methods: twenty-six patients with intermittent claudication and 22 matched healthy control subjects each had IL-8 levels measured before and after a standard acute treadmill-exercise test. Subjects walked for 10 min or until stopped by claudication pain. Serum IL-8 levels were measured before exercise was commenced and 1, 5 and 10 min after exercise was stopped.Results: patients with PAOD had statistically significantly higher levels of IL-8 than healthy control subjects, before and after an acute exercise test (p <0.00001, Mann–Whitney). Ratios of the change of IL-8 levels post-exercise showed a statistically significant difference at the post-5-min time point (/E2>p =0.005), showing a difference in the change of IL-8 levels at this time point between the patient group and control group. Conclusions: The increased levels and the failure of the cytokine levels to fall by the same extent after exercise in the patient group may be due to a combination of increased neutrophil activation, reduced blood flow and increased cytokine production during ischaemia–reperfusion, which is not observed in the healthy controls.

    U2 - 10.1053/ejvs.1999.0927

    DO - 10.1053/ejvs.1999.0927

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    SN - 1078-5884

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