International Consortium on Mammographic Density

methodology and population diversity captured across 22 countries

Valerie A. McCormack (Lead / Corresponding author), Anya Burton, Isabel dos-Santos-Silva, John H. Hipwell, Caroline Dickens, Dorria Salem, Rasha Kamal, Mikael Hartman, Charmaine Pei Ling Lee, Kee-Seng Chia, Vahit Ozmen, Mustafa Erkin Aribal, Anath Arzee Flugelman, Martín Lajous, Ruy Lopez-Riduara, Megan Rice, Isabelle Romieu, Giske Ursin, Samera Qureshi, Huiyan Ma & 36 others Eunjung Lee, Carla H. van Gils, Johanna O. P. Wanders, Sudhir Vinayak, Rose Ndumia, Steve Allen, Sarah Vinnicombe, Sue Moss, Jong Won Lee, Jisun Kim, Ana Pereira, Maria Luisa Garmendia, Reza Sirous, Mehri Sirous, Beata Peplonska, Agnieszka Bukowska, Rulla M. Tamimi, Kimberly Bertrand, Chisato Nagata, Ava Kwong, Celine Vachon, Christopher Scott, Beatriz Perez-Gomez, Marina Pollan, Gertraud Maskarinec, Graham Giles, John Hopper, Jennifer Stone, Nadia Rajaram, Soo-Hwang Teo, Shivaani Mariapun, Martin J. Yaffe, Joachim Schüz, Anna M. Chiarelli, Linda Linton, Norman F. Boyd

    Research output: Contribution to journalArticle

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    Abstract

    Mammographic density (MD) is a quantitative trait, measurable in all women, and is among the strongest markers of breast cancer risk. The population-based epidemiology of MD has revealed genetic, lifestyle and societal/environmental determinants, but studies have largely been conducted in women with similar westernized lifestyles living in countries with high breast cancer incidence rates. To benefit from the heterogeneity in risk factors and their combinations worldwide, we created an International Consortium on Mammographic Density (ICMD) to pool individual-level epidemiological and MD data from general population studies worldwide. ICMD aims to characterize determinants of MD more precisely, and to evaluate whether they are consistent across populations worldwide. We included 11755 women, from 27 studies in 22 countries, on whom individual-level risk factor data were pooled and original mammographic images were re-read for ICMD to obtain standardized comparable MD data. In the present article, we present (i) the rationale for this consortium; (ii) characteristics of the studies and women included; and (iii) study methodology to obtain comparable MD data from original re-read films. We also highlight the risk factor heterogeneity captured by such an effort and, thus, the unique insight the pooled study promises to offer through wider exposure ranges, different confounding structures and enhanced power for sub-group analyses.

    Original languageEnglish
    Pages (from-to)141-151
    Number of pages11
    JournalCancer Epidemiology
    Volume40
    Early online date24 Dec 2015
    DOIs
    Publication statusPublished - Feb 2016

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    Population
    Life Style
    Breast Neoplasms
    Breast Density
    Epidemiology
    Incidence

    Cite this

    McCormack, V. A., Burton, A., dos-Santos-Silva, I., Hipwell, J. H., Dickens, C., Salem, D., ... Boyd, N. F. (2016). International Consortium on Mammographic Density: methodology and population diversity captured across 22 countries. Cancer Epidemiology, 40, 141-151. https://doi.org/10.1016/j.canep.2015.11.015
    McCormack, Valerie A. ; Burton, Anya ; dos-Santos-Silva, Isabel ; Hipwell, John H. ; Dickens, Caroline ; Salem, Dorria ; Kamal, Rasha ; Hartman, Mikael ; Lee, Charmaine Pei Ling ; Chia, Kee-Seng ; Ozmen, Vahit ; Aribal, Mustafa Erkin ; Flugelman, Anath Arzee ; Lajous, Martín ; Lopez-Riduara, Ruy ; Rice, Megan ; Romieu, Isabelle ; Ursin, Giske ; Qureshi, Samera ; Ma, Huiyan ; Lee, Eunjung ; van Gils, Carla H. ; Wanders, Johanna O. P. ; Vinayak, Sudhir ; Ndumia, Rose ; Allen, Steve ; Vinnicombe, Sarah ; Moss, Sue ; Won Lee, Jong ; Kim, Jisun ; Pereira, Ana ; Garmendia, Maria Luisa ; Sirous, Reza ; Sirous, Mehri ; Peplonska, Beata ; Bukowska, Agnieszka ; Tamimi, Rulla M. ; Bertrand, Kimberly ; Nagata, Chisato ; Kwong, Ava ; Vachon, Celine ; Scott, Christopher ; Perez-Gomez, Beatriz ; Pollan, Marina ; Maskarinec, Gertraud ; Giles, Graham ; Hopper, John ; Stone, Jennifer ; Rajaram, Nadia ; Teo, Soo-Hwang ; Mariapun, Shivaani ; Yaffe, Martin J. ; Schüz, Joachim ; Chiarelli, Anna M. ; Linton, Linda ; Boyd, Norman F. / International Consortium on Mammographic Density : methodology and population diversity captured across 22 countries. In: Cancer Epidemiology. 2016 ; Vol. 40. pp. 141-151.
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    abstract = "Mammographic density (MD) is a quantitative trait, measurable in all women, and is among the strongest markers of breast cancer risk. The population-based epidemiology of MD has revealed genetic, lifestyle and societal/environmental determinants, but studies have largely been conducted in women with similar westernized lifestyles living in countries with high breast cancer incidence rates. To benefit from the heterogeneity in risk factors and their combinations worldwide, we created an International Consortium on Mammographic Density (ICMD) to pool individual-level epidemiological and MD data from general population studies worldwide. ICMD aims to characterize determinants of MD more precisely, and to evaluate whether they are consistent across populations worldwide. We included 11755 women, from 27 studies in 22 countries, on whom individual-level risk factor data were pooled and original mammographic images were re-read for ICMD to obtain standardized comparable MD data. In the present article, we present (i) the rationale for this consortium; (ii) characteristics of the studies and women included; and (iii) study methodology to obtain comparable MD data from original re-read films. We also highlight the risk factor heterogeneity captured by such an effort and, thus, the unique insight the pooled study promises to offer through wider exposure ranges, different confounding structures and enhanced power for sub-group analyses.",
    author = "McCormack, {Valerie A.} and Anya Burton and Isabel dos-Santos-Silva and Hipwell, {John H.} and Caroline Dickens and Dorria Salem and Rasha Kamal and Mikael Hartman and Lee, {Charmaine Pei Ling} and Kee-Seng Chia and Vahit Ozmen and Aribal, {Mustafa Erkin} and Flugelman, {Anath Arzee} and Mart{\'i}n Lajous and Ruy Lopez-Riduara and Megan Rice and Isabelle Romieu and Giske Ursin and Samera Qureshi and Huiyan Ma and Eunjung Lee and {van Gils}, {Carla H.} and Wanders, {Johanna O. P.} and Sudhir Vinayak and Rose Ndumia and Steve Allen and Sarah Vinnicombe and Sue Moss and {Won Lee}, Jong and Jisun Kim and Ana Pereira and Garmendia, {Maria Luisa} and Reza Sirous and Mehri Sirous and Beata Peplonska and Agnieszka Bukowska and Tamimi, {Rulla M.} and Kimberly Bertrand and Chisato Nagata and Ava Kwong and Celine Vachon and Christopher Scott and Beatriz Perez-Gomez and Marina Pollan and Gertraud Maskarinec and Graham Giles and John Hopper and Jennifer Stone and Nadia Rajaram and Soo-Hwang Teo and Shivaani Mariapun and Yaffe, {Martin J.} and Joachim Sch{\"u}z and Chiarelli, {Anna M.} and Linda Linton and Boyd, {Norman F.}",
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    year = "2016",
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    doi = "10.1016/j.canep.2015.11.015",
    language = "English",
    volume = "40",
    pages = "141--151",
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    McCormack, VA, Burton, A, dos-Santos-Silva, I, Hipwell, JH, Dickens, C, Salem, D, Kamal, R, Hartman, M, Lee, CPL, Chia, K-S, Ozmen, V, Aribal, ME, Flugelman, AA, Lajous, M, Lopez-Riduara, R, Rice, M, Romieu, I, Ursin, G, Qureshi, S, Ma, H, Lee, E, van Gils, CH, Wanders, JOP, Vinayak, S, Ndumia, R, Allen, S, Vinnicombe, S, Moss, S, Won Lee, J, Kim, J, Pereira, A, Garmendia, ML, Sirous, R, Sirous, M, Peplonska, B, Bukowska, A, Tamimi, RM, Bertrand, K, Nagata, C, Kwong, A, Vachon, C, Scott, C, Perez-Gomez, B, Pollan, M, Maskarinec, G, Giles, G, Hopper, J, Stone, J, Rajaram, N, Teo, S-H, Mariapun, S, Yaffe, MJ, Schüz, J, Chiarelli, AM, Linton, L & Boyd, NF 2016, 'International Consortium on Mammographic Density: methodology and population diversity captured across 22 countries', Cancer Epidemiology, vol. 40, pp. 141-151. https://doi.org/10.1016/j.canep.2015.11.015

    International Consortium on Mammographic Density : methodology and population diversity captured across 22 countries. / McCormack, Valerie A. (Lead / Corresponding author); Burton, Anya; dos-Santos-Silva, Isabel; Hipwell, John H.; Dickens, Caroline; Salem, Dorria; Kamal, Rasha; Hartman, Mikael; Lee, Charmaine Pei Ling; Chia, Kee-Seng; Ozmen, Vahit; Aribal, Mustafa Erkin; Flugelman, Anath Arzee; Lajous, Martín; Lopez-Riduara, Ruy; Rice, Megan; Romieu, Isabelle; Ursin, Giske; Qureshi, Samera; Ma, Huiyan; Lee, Eunjung; van Gils, Carla H.; Wanders, Johanna O. P.; Vinayak, Sudhir; Ndumia, Rose; Allen, Steve; Vinnicombe, Sarah; Moss, Sue; Won Lee, Jong; Kim, Jisun; Pereira, Ana; Garmendia, Maria Luisa; Sirous, Reza; Sirous, Mehri; Peplonska, Beata; Bukowska, Agnieszka; Tamimi, Rulla M.; Bertrand, Kimberly; Nagata, Chisato; Kwong, Ava; Vachon, Celine; Scott, Christopher; Perez-Gomez, Beatriz; Pollan, Marina; Maskarinec, Gertraud; Giles, Graham; Hopper, John; Stone, Jennifer; Rajaram, Nadia; Teo, Soo-Hwang; Mariapun, Shivaani; Yaffe, Martin J.; Schüz, Joachim; Chiarelli, Anna M.; Linton, Linda; Boyd, Norman F.

    In: Cancer Epidemiology, Vol. 40, 02.2016, p. 141-151.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - International Consortium on Mammographic Density

    T2 - methodology and population diversity captured across 22 countries

    AU - McCormack, Valerie A.

    AU - Burton, Anya

    AU - dos-Santos-Silva, Isabel

    AU - Hipwell, John H.

    AU - Dickens, Caroline

    AU - Salem, Dorria

    AU - Kamal, Rasha

    AU - Hartman, Mikael

    AU - Lee, Charmaine Pei Ling

    AU - Chia, Kee-Seng

    AU - Ozmen, Vahit

    AU - Aribal, Mustafa Erkin

    AU - Flugelman, Anath Arzee

    AU - Lajous, Martín

    AU - Lopez-Riduara, Ruy

    AU - Rice, Megan

    AU - Romieu, Isabelle

    AU - Ursin, Giske

    AU - Qureshi, Samera

    AU - Ma, Huiyan

    AU - Lee, Eunjung

    AU - van Gils, Carla H.

    AU - Wanders, Johanna O. P.

    AU - Vinayak, Sudhir

    AU - Ndumia, Rose

    AU - Allen, Steve

    AU - Vinnicombe, Sarah

    AU - Moss, Sue

    AU - Won Lee, Jong

    AU - Kim, Jisun

    AU - Pereira, Ana

    AU - Garmendia, Maria Luisa

    AU - Sirous, Reza

    AU - Sirous, Mehri

    AU - Peplonska, Beata

    AU - Bukowska, Agnieszka

    AU - Tamimi, Rulla M.

    AU - Bertrand, Kimberly

    AU - Nagata, Chisato

    AU - Kwong, Ava

    AU - Vachon, Celine

    AU - Scott, Christopher

    AU - Perez-Gomez, Beatriz

    AU - Pollan, Marina

    AU - Maskarinec, Gertraud

    AU - Giles, Graham

    AU - Hopper, John

    AU - Stone, Jennifer

    AU - Rajaram, Nadia

    AU - Teo, Soo-Hwang

    AU - Mariapun, Shivaani

    AU - Yaffe, Martin J.

    AU - Schüz, Joachim

    AU - Chiarelli, Anna M.

    AU - Linton, Linda

    AU - Boyd, Norman F.

    N1 - Copyright © 2015 Elsevier Ltd. All rights reserved.

    PY - 2016/2

    Y1 - 2016/2

    N2 - Mammographic density (MD) is a quantitative trait, measurable in all women, and is among the strongest markers of breast cancer risk. The population-based epidemiology of MD has revealed genetic, lifestyle and societal/environmental determinants, but studies have largely been conducted in women with similar westernized lifestyles living in countries with high breast cancer incidence rates. To benefit from the heterogeneity in risk factors and their combinations worldwide, we created an International Consortium on Mammographic Density (ICMD) to pool individual-level epidemiological and MD data from general population studies worldwide. ICMD aims to characterize determinants of MD more precisely, and to evaluate whether they are consistent across populations worldwide. We included 11755 women, from 27 studies in 22 countries, on whom individual-level risk factor data were pooled and original mammographic images were re-read for ICMD to obtain standardized comparable MD data. In the present article, we present (i) the rationale for this consortium; (ii) characteristics of the studies and women included; and (iii) study methodology to obtain comparable MD data from original re-read films. We also highlight the risk factor heterogeneity captured by such an effort and, thus, the unique insight the pooled study promises to offer through wider exposure ranges, different confounding structures and enhanced power for sub-group analyses.

    AB - Mammographic density (MD) is a quantitative trait, measurable in all women, and is among the strongest markers of breast cancer risk. The population-based epidemiology of MD has revealed genetic, lifestyle and societal/environmental determinants, but studies have largely been conducted in women with similar westernized lifestyles living in countries with high breast cancer incidence rates. To benefit from the heterogeneity in risk factors and their combinations worldwide, we created an International Consortium on Mammographic Density (ICMD) to pool individual-level epidemiological and MD data from general population studies worldwide. ICMD aims to characterize determinants of MD more precisely, and to evaluate whether they are consistent across populations worldwide. We included 11755 women, from 27 studies in 22 countries, on whom individual-level risk factor data were pooled and original mammographic images were re-read for ICMD to obtain standardized comparable MD data. In the present article, we present (i) the rationale for this consortium; (ii) characteristics of the studies and women included; and (iii) study methodology to obtain comparable MD data from original re-read films. We also highlight the risk factor heterogeneity captured by such an effort and, thus, the unique insight the pooled study promises to offer through wider exposure ranges, different confounding structures and enhanced power for sub-group analyses.

    U2 - 10.1016/j.canep.2015.11.015

    DO - 10.1016/j.canep.2015.11.015

    M3 - Article

    VL - 40

    SP - 141

    EP - 151

    JO - Cancer Epidemiology

    JF - Cancer Epidemiology

    SN - 1877-7821

    ER -