Internodal potassium currents can generate ectopic impulses in mammalian myelinated axons

Raju Kapoor; Kenneth J. Smith; Paul A. Felts; Meirion Davies

doi:10.1016/0006-8993(93)91790-Y

Internodal potassium currents can generate ectopic impulses in mammalian myelinated axons

Raju Kapoor, Kenneth J. Smith, Paul A. Felts, Meirion Davies

Centre for Anatomy and Human Identification

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Positive clinical symptoms can arise from ectopic action potentials in several disorders of myelinated axons. Here we report that an elevated K⁺ concentration in the periaxonal, internodal space can cause internodal K⁺ currents to become excitatory, resulting in slow potential oscillations and associated bursts of ectopic spikes. Ectopic firing may therefore be favoured by conditions in which periaxonal K⁺ buffering is compromised.

Original language	English
Pages (from-to)	165-169
Number of pages	5
Journal	Brain Research
Volume	611
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(93)91790-Y
Publication status	Published - 14 May 1993

Keywords

4-Aminopyridine
Action potential
Ectopic firing
Periaxonal space
Positive symptom
Potassium channel
Tetraethylammonium

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(93)91790-Y

Cite this

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abstract = "Positive clinical symptoms can arise from ectopic action potentials in several disorders of myelinated axons. Here we report that an elevated K+ concentration in the periaxonal, internodal space can cause internodal K+ currents to become excitatory, resulting in slow potential oscillations and associated bursts of ectopic spikes. Ectopic firing may therefore be favoured by conditions in which periaxonal K+ buffering is compromised.",

keywords = "4-Aminopyridine, Action potential, Ectopic firing, Periaxonal space, Positive symptom, Potassium channel, Tetraethylammonium",

author = "Raju Kapoor and Smith, {Kenneth J.} and Felts, {Paul A.} and Meirion Davies",

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AU - Kapoor, Raju

AU - Smith, Kenneth J.

AU - Felts, Paul A.

AU - Davies, Meirion

PY - 1993/5/14

Y1 - 1993/5/14

N2 - Positive clinical symptoms can arise from ectopic action potentials in several disorders of myelinated axons. Here we report that an elevated K+ concentration in the periaxonal, internodal space can cause internodal K+ currents to become excitatory, resulting in slow potential oscillations and associated bursts of ectopic spikes. Ectopic firing may therefore be favoured by conditions in which periaxonal K+ buffering is compromised.

AB - Positive clinical symptoms can arise from ectopic action potentials in several disorders of myelinated axons. Here we report that an elevated K+ concentration in the periaxonal, internodal space can cause internodal K+ currents to become excitatory, resulting in slow potential oscillations and associated bursts of ectopic spikes. Ectopic firing may therefore be favoured by conditions in which periaxonal K+ buffering is compromised.

KW - 4-Aminopyridine

KW - Action potential

KW - Ectopic firing

KW - Periaxonal space

KW - Positive symptom

KW - Potassium channel

KW - Tetraethylammonium

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DO - 10.1016/0006-8993(93)91790-Y

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JF - Brain Research

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ER -

Internodal potassium currents can generate ectopic impulses in mammalian myelinated axons

Abstract

Keywords

ASJC Scopus subject areas

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