Internodal potassium currents can generate ectopic impulses in mammalian myelinated axons

TY - JOUR

T1 - Internodal potassium currents can generate ectopic impulses in mammalian myelinated axons

AU - Kapoor, Raju

AU - Smith, Kenneth J.

AU - Felts, Paul A.

AU - Davies, Meirion

PY - 1993/5/14

Y1 - 1993/5/14

N2 - Positive clinical symptoms can arise from ectopic action potentials in several disorders of myelinated axons. Here we report that an elevated K+ concentration in the periaxonal, internodal space can cause internodal K+ currents to become excitatory, resulting in slow potential oscillations and associated bursts of ectopic spikes. Ectopic firing may therefore be favoured by conditions in which periaxonal K+ buffering is compromised.

AB - Positive clinical symptoms can arise from ectopic action potentials in several disorders of myelinated axons. Here we report that an elevated K+ concentration in the periaxonal, internodal space can cause internodal K+ currents to become excitatory, resulting in slow potential oscillations and associated bursts of ectopic spikes. Ectopic firing may therefore be favoured by conditions in which periaxonal K+ buffering is compromised.

KW - 4-Aminopyridine

KW - Action potential

KW - Ectopic firing

KW - Periaxonal space

KW - Positive symptom

KW - Potassium channel

KW - Tetraethylammonium

UR - https://www.scopus.com/pages/publications/0027153109

U2 - 10.1016/0006-8993(93)91790-Y

DO - 10.1016/0006-8993(93)91790-Y

M3 - Article

C2 - 8518945

AN - SCOPUS:0027153109

SN - 0006-8993

VL - 611

SP - 165

EP - 169

JO - Brain Research

JF - Brain Research

IS - 1

ER -