Interplay between TRP channels and the cytoskeleton in health and disease

Kristopher Clark, Jeroen Middelbeek, Frank N. van Leeuwen

    Research output: Contribution to journalArticlepeer-review

    43 Citations (Scopus)


    Transient receptor potential (TRP) channels are a family of cation channels that play a key role in ion homeostasis and cell volume regulation. In addition, TRP channels are considered universal integrators of sensory information required for taste, vision, hearing, touch, temperature, and the detection of mechanical force. Seminal investigations exploring the molecular mechanisms of phototransduction in Drosophila have demonstrated that TRP channels operate within macromolecular complexes closely associated with the cytoskeleton. More recent evidence shows that mammalian TRP channels similarly connect to the cytoskeleton to affect cytoskeletal organization and cell adhesion via ion-transport-dependent and -independent mechanisms. In this review, we discuss new insights into the interplay between TRP channels and the cytoskeleton and provide recent examples of such interactions in different physiological systems.

    Original languageEnglish
    Pages (from-to)631-640
    Number of pages10
    JournalEuropean Journal of Cell Biology
    Issue number8-9
    Publication statusPublished - 4 Sept 2008


    • Animals
    • Cytoskeleton
    • Drosophila Proteins
    • Drosophila melanogaster
    • Endothelial Cells
    • Hearing Disorders
    • Humans
    • Kidney
    • Kidney Diseases
    • Models, Biological
    • Transient Receptor Potential Channels
    • Vision, Ocular


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