Abstract
Background: Between 2000 and 2007, a demonstration pilot of biennial guaiac faecal occult blood test (GFOBT) screening was carried out in Scotland. Methods: Interval cancers were defined as cancers diagnosed within 2 years (ie, a complete screening round) of a negative GFOBT. The stage and outcome of the interval cancers were compared with those arising contemporaneously in the non-screened Scottish population. In addition, the gender and site distributions of the interval cancers were compared with those in the screen-detected group and the non-screened population. Results: Of the cancers diagnosed in the screened population, interval cancers comprised 31.2% in the first round, 47.7% in the second, and 58.9% in the third, although this was due to a decline in the numbers of screen-detected cancers rather than an increase in interval cancers. There were no consistent differences in the stage distribution of interval cancers and cancers from the non-screened population, and, in all three rounds, both overall and cancer-specific survival were significantly better for patients diagnosed with interval cancers (p
Original language | English |
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Pages (from-to) | 576-581 |
Number of pages | 6 |
Journal | Gut |
Volume | 61 |
Issue number | 4 |
Early online date | 19 Sept 2011 |
DOIs | |
Publication status | Published - 1 Apr 2012 |
Keywords
- Adult
- Aged
- Article
- Cancer localization
- Cancer prognosis
- Cancer screening
- Cancer specific survival
- Cancer staging
- Clinical evaluation
- Colorectal cancer
- Controlled study
- Diagnostic accuracy
- Disease duration
- Female
- Human
- Major clinical study
- Male
- Occult blood test
- Overall survival
- Pathological anatomy
- Priority journal
- Sex difference