Interval cancers in a FOBT-based colorectal cancer population screening programme: implications for stage, gender and tumour site

R. J. C. Steele, P. McClements, C. Watling, G. Libby, D. Weller, D .H. Brewster, R. Black, F. A. Carey, C. G. Fraser

    Research output: Contribution to journalArticle

    95 Citations (Scopus)

    Abstract

    Background: Between 2000 and 2007, a demonstration pilot of biennial guaiac faecal occult blood test (GFOBT) screening was carried out in Scotland. Methods: Interval cancers were defined as cancers diagnosed within 2 years (ie, a complete screening round) of a negative GFOBT. The stage and outcome of the interval cancers were compared with those arising contemporaneously in the non-screened Scottish population. In addition, the gender and site distributions of the interval cancers were compared with those in the screen-detected group and the non-screened population. Results: Of the cancers diagnosed in the screened population, interval cancers comprised 31.2% in the first round, 47.7% in the second, and 58.9% in the third, although this was due to a decline in the numbers of screen-detected cancers rather than an increase in interval cancers. There were no consistent differences in the stage distribution of interval cancers and cancers from the non-screened population, and, in all three rounds, both overall and cancer-specific survival were significantly better for patients diagnosed with interval cancers (p
    Original languageEnglish
    Pages (from-to)576-581
    Number of pages6
    JournalGut
    Volume61
    Issue number4
    Early online date19 Sep 2011
    DOIs
    Publication statusPublished - 1 Apr 2012

    Keywords

    • Adult
    • Aged
    • Article
    • Cancer localization
    • Cancer prognosis
    • Cancer screening
    • Cancer specific survival
    • Cancer staging
    • Clinical evaluation
    • Colorectal cancer
    • Controlled study
    • Diagnostic accuracy
    • Disease duration
    • Female
    • Human
    • Major clinical study
    • Male
    • Occult blood test
    • Overall survival
    • Pathological anatomy
    • Priority journal
    • Sex difference

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