Interventions to prevent non-critical care hospital acquired pneumonia – a systematic review

S. M. McAuley, R. J. G. Price, G. Phillips, C. A. Marwick, M. E. T. McMurdo, M. D. Witham (Lead / Corresponding author)

    Research output: Contribution to journalArticle

    4 Citations (Scopus)
    91 Downloads (Pure)

    Abstract

    Background: Hospital-acquired pneumonia is a significant burden to healthcare systems around the world. Although there is a considerable body of evidence on prevention of ventilator associated pneumonia, less is known about strategies to prevent hospital-acquired pneumonia in non-critical care settings. Objective: To systematically review the randomised controlled trial evidence for prevention of hospital-acquired pneumonia in non-critical care settings. Methods: We searched EMBASE, CINAHL+, MEDLINE and the Cochrane Library. Seventeen different searches were conducted in parallel through each database. Studies were included if they were randomised controlled trials reporting hospital-acquired pneumonia as an endpoint. Studies were excluded if they were performed in critical care or community settings. All studies published up to the end of December 2014 were considered, with no language restrictions. Data were independently extracted by two authors and the Delphi risk of bias tool was applied to assess trial quality. Results: Five thousand one hundred and one titles were identified across 17 searches. Only two studies were eligible for inclusion in the final review, one from a search of physical therapy interventions and one from a search of enteral feeding. The heterogeneity of the interventions did not permit meta-analysis. One trial suggested possible benefits to early mobilisation; the other trial suggested no benefit or harm from early enteral feeding via nasogastric tube. Both trials enrolled patients with acute stroke. No trials in non-stroke, non-critical care populations were eligible for inclusion in the review. Conclusions: There is currently insufficient trial evidence on preventing non-critical care hospital-acquired pneumonia to make recommendations on practice.

    Original languageEnglish
    Pages (from-to)336-340
    Number of pages5
    JournalEuropean Geriatric Medicine
    Volume6
    Issue number4
    Early online date23 Apr 2015
    DOIs
    Publication statusPublished - Jul 2015

    Fingerprint

    Pneumonia
    Enteral Nutrition
    Randomized Controlled Trials
    Ventilator-Associated Pneumonia
    Early Ambulation
    Critical Care
    MEDLINE
    Libraries
    Meta-Analysis
    Language
    Stroke
    Databases
    Delivery of Health Care
    Population
    Therapeutics

    Keywords

    • Nosocomial
    • Older
    • Pneumonia
    • Randomised controlled trials
    • Systematic review

    Cite this

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    title = "Interventions to prevent non-critical care hospital acquired pneumonia – a systematic review",
    abstract = "Background: Hospital-acquired pneumonia is a significant burden to healthcare systems around the world. Although there is a considerable body of evidence on prevention of ventilator associated pneumonia, less is known about strategies to prevent hospital-acquired pneumonia in non-critical care settings. Objective: To systematically review the randomised controlled trial evidence for prevention of hospital-acquired pneumonia in non-critical care settings. Methods: We searched EMBASE, CINAHL+, MEDLINE and the Cochrane Library. Seventeen different searches were conducted in parallel through each database. Studies were included if they were randomised controlled trials reporting hospital-acquired pneumonia as an endpoint. Studies were excluded if they were performed in critical care or community settings. All studies published up to the end of December 2014 were considered, with no language restrictions. Data were independently extracted by two authors and the Delphi risk of bias tool was applied to assess trial quality. Results: Five thousand one hundred and one titles were identified across 17 searches. Only two studies were eligible for inclusion in the final review, one from a search of physical therapy interventions and one from a search of enteral feeding. The heterogeneity of the interventions did not permit meta-analysis. One trial suggested possible benefits to early mobilisation; the other trial suggested no benefit or harm from early enteral feeding via nasogastric tube. Both trials enrolled patients with acute stroke. No trials in non-stroke, non-critical care populations were eligible for inclusion in the review. Conclusions: There is currently insufficient trial evidence on preventing non-critical care hospital-acquired pneumonia to make recommendations on practice.",
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    author = "McAuley, {S. M.} and Price, {R. J. G.} and G. Phillips and Marwick, {C. A.} and McMurdo, {M. E. T.} and Witham, {M. D.}",
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    Interventions to prevent non-critical care hospital acquired pneumonia – a systematic review. / McAuley, S. M.; Price, R. J. G.; Phillips, G.; Marwick, C. A.; McMurdo, M. E. T.; Witham, M. D. (Lead / Corresponding author).

    In: European Geriatric Medicine, Vol. 6, No. 4, 07.2015, p. 336-340.

    Research output: Contribution to journalArticle

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    AU - McAuley, S. M.

    AU - Price, R. J. G.

    AU - Phillips, G.

    AU - Marwick, C. A.

    AU - McMurdo, M. E. T.

    AU - Witham, M. D.

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