Intestinal bacteria and inflammatory bowel disease

Sandra Macfarlane, Helen Steed, George T. Macfarlane

    Research output: Contribution to journalReview articlepeer-review

    72 Citations (Scopus)

    Abstract

    Crohn's disease ( CD) and ulcerative colitis ( UC) are the two principal forms of inflammatory bowel disease ( IBD). Animal studies show that bacteria are involved in the etiology of IBD, and much is now known about the inflammatory processes associated with CD and UC, as well as the underlying genetic, environmental, and lifestyle issues that can affect an individual's predisposition to these diseases. However, while a number of candidate microorganisms have been put forward as causative factors in IBD, the primary etiologic agents are unknown. This review discusses the potential role of luminal and mucosal microbial communities in the etiology of IBD, and outlines studies that have been made using a variety of biotherapeutic therapies, involving the use of antibiotics, probiotics, prebiotics, and synbiotics.

    Original languageEnglish
    Pages (from-to)25-54
    Number of pages30
    JournalCritical Reviews in Clinical Laboratory Sciences
    Volume46
    Issue number1
    DOIs
    Publication statusPublished - Feb 2009

    Keywords

    • Antibiotics
    • Crohn's disease
    • Colon
    • Microbiota
    • Mucosal bacteria
    • Mycobacteria
    • Prebiotics
    • Probiotics
    • Sulfate-reducing bacteria
    • Synbiotics
    • Ulcerative colitis
    • Active Crohns disease
    • Avium subspecies paratuberculosis
    • Placebo controlled trial
    • Randomized controlled trials
    • Invasive escherichia coli
    • Polymerase chain reaction
    • Severe ulcerative colitis
    • Antibiotic combination therapy
    • Bifidobacteria fermented milk

    Cite this