Introducing histone modification in trypanosomes

Research output: Contribution to journalShort surveypeer-review

17 Citations (Scopus)

Abstract

Nuclear DNA is wrapped around histones. Vigorous research over the past decade has established a central role for histone post-translational modification in controlling the DNA-protein interactions that are required for successful growth and propagation. Recent work now provides a description of acetylated and methylated residues in the divergent trypanosome core histones. Future studies should provide insights into the genomic distribution of each modification and their roles in growth and pathogenesis.

Original languageEnglish
Pages (from-to)239-242
Number of pages4
JournalTrends in Parasitology
Volume23
Issue number6
DOIs
Publication statusPublished - Jun 2007

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