Investigating tissue respiration and skin microhaemocirculation under adaptive changes and the synchronization of blood flow and oxygen saturation rhythms

A. V. Dunaev (Lead / Corresponding author), V. V. Sidorov, A. I. Krupatkin, I.E. Rafailov, S. G. Palmer, N. A. Stewart, S. G. Sokolovski, E. U. Rafailov

    Research output: Contribution to journalArticle

    32 Citations (Scopus)

    Abstract

    Multi-functional laser non-invasive diagnostic systems allow the study of a number of microcirculatory parameters, including index of blood microcirculation (Im) (by laser Doppler flowmetry, LDF) and oxygen saturation (StO2) of skin tissue (by tissue reflectance oximetry, TRO). This research aimed to use such a system to investigate the synchronization of microvascular blood flow and oxygen saturation rhythms under normal and adaptive change conditions. Studies were conducted on eight healthy volunteers of 21-49 years. These volunteers were observed between one and six months, totalling 422 basic tests (3 min each). Measurements were performed on the palmar surface of the right middle finger and the lower forearm's medial surface. Rhythmic oscillations of LDF and TRO were studied using wavelet analysis. Combined tissue oxygen consumption data for all volunteers during 'adaptive changes' increased relative to normal conditions with and without arteriovenous anastomoses. Data analysis revealed resonance and synchronized rhythms in microvascular blood flow and oxygen saturation as an adaptive change in myogenic oscillation (vasomotion) resulting from exercise and possibly psychoemotional stress. Synchronization of myogenic rhythms during adaptive changes may lead to increased oxygen consumption as a result of increased microvascular blood flow velocity.
    Original languageEnglish
    Pages (from-to)607-621
    Number of pages15
    JournalPhysiological Measurement
    Volume35
    Issue number4
    DOIs
    Publication statusPublished - 12 Mar 2014

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  • Student Theses

    Development of non-invasive techniques for bladder cancer diagnosis and therapy

    Author: Palmer, S. G., 2016

    Supervisor: Nabi, G. (Supervisor) & McGloin, D. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

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    Dunaev, A. V., Sidorov, V. V., Krupatkin, A. I., Rafailov, I. E., Palmer, S. G., Stewart, N. A., Sokolovski, S. G., & Rafailov, E. U. (2014). Investigating tissue respiration and skin microhaemocirculation under adaptive changes and the synchronization of blood flow and oxygen saturation rhythms. Physiological Measurement, 35(4), 607-621. https://doi.org/10.1088/0967-3334/35/4/607