Investigation into the acoustic transparency of reconstituted mucus

Mihnea V. Turcanu; Manlio Tassieri; Maya Thanou; Inke Nathke; Sandy Cochran

doi:10.1109/IUS54386.2022.9958505

Investigation into the acoustic transparency of reconstituted mucus

Mihnea V. Turcanu, Manlio Tassieri, Maya Thanou, Inke Nathke, Sandy Cochran

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

122 Downloads (Pure)

Abstract

Ultrasound (US) smart capsules are being developed with the potential to deliver medication via sonoporation in the intestine. However, a layer of mucus that can represent a barrier lines the luminal surface of the intestine. Consequently, it is important to study the propagation of US through mucus to the underlying mucosal cell layer. In order to promote sonoporation, it must be ensured that US propagates efficiently though the mucus, reaches sonoporation agents, such as microbubbles, and thus promotes cavitation. The objective of this work was to investigate the acoustic transparency of mucus. A 7 mm thick layer of mucus caused attenuation of 0.93 ± 0.16 dB/cm for a 4 MHz US signal. When controlled for the thickness of the mucus in the small intestine, mucus reduced the signal amplitude by 0.01 - 0.2%. Notably, the outcomes of this work are also relevant to US therapeutic devices acting in other cavities lined by mucus, such as the respiratory, excretory and female reproductive tracts.

Original language	English
Title of host publication	2022 IEEE International Ultrasonics Symposium (IUS)
Publisher	IEEE
Number of pages	3
ISBN (Electronic)	9781665466578
ISBN (Print)	9781665478137
DOIs	https://doi.org/10.1109/IUS54386.2022.9958505
Publication status	Published - 1 Dec 2022
Event	2022 IEEE International Ultrasonics Symposium - Venice, Italy Duration: 10 Oct 2022 → 13 Oct 2022

Publication series

Name
ISSN (Print)	1948-5719
ISSN (Electronic)	1948-5727

Conference

Conference	2022 IEEE International Ultrasonics Symposium
Abbreviated title	IUS 2022
Country/Territory	Italy
City	Venice
Period	10/10/22 → 13/10/22

Keywords

acoustic transparency
barrier function
drug delivery
mucus

ASJC Scopus subject areas

Acoustics and Ultrasonics

Access to Document

10.1109/IUS54386.2022.9958505

Author Accepted ManuscriptAccepted author manuscript, 372 KB

Cite this

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title = "Investigation into the acoustic transparency of reconstituted mucus",

abstract = "Ultrasound (US) smart capsules are being developed with the potential to deliver medication via sonoporation in the intestine. However, a layer of mucus that can represent a barrier lines the luminal surface of the intestine. Consequently, it is important to study the propagation of US through mucus to the underlying mucosal cell layer. In order to promote sonoporation, it must be ensured that US propagates efficiently though the mucus, reaches sonoporation agents, such as microbubbles, and thus promotes cavitation. The objective of this work was to investigate the acoustic transparency of mucus. A 7 mm thick layer of mucus caused attenuation of 0.93 ± 0.16 dB/cm for a 4 MHz US signal. When controlled for the thickness of the mucus in the small intestine, mucus reduced the signal amplitude by 0.01 - 0.2%. Notably, the outcomes of this work are also relevant to US therapeutic devices acting in other cavities lined by mucus, such as the respiratory, excretory and female reproductive tracts.",

keywords = "acoustic transparency, barrier function, drug delivery, mucus",

author = "Turcanu, {Mihnea V.} and Manlio Tassieri and Maya Thanou and Inke Nathke and Sandy Cochran",

note = "Funding Information: This work was supported by the UK Engineering and Physical Sciences Research Council (EPSRC) under grant number EP/K034537 “Sonopill” and the UK Biotechnology and Biological Sciences Research Council (BBSRC), project reference 1810028. Publisher Copyright: {\textcopyright} 2022 IEEE.; 2022 IEEE International Ultrasonics Symposium, IUS 2022 ; Conference date: 10-10-2022 Through 13-10-2022",

year = "2022",

month = dec,

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doi = "10.1109/IUS54386.2022.9958505",

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T1 - Investigation into the acoustic transparency of reconstituted mucus

AU - Turcanu, Mihnea V.

AU - Tassieri, Manlio

AU - Thanou, Maya

AU - Nathke, Inke

AU - Cochran, Sandy

N1 - Funding Information: This work was supported by the UK Engineering and Physical Sciences Research Council (EPSRC) under grant number EP/K034537 “Sonopill” and the UK Biotechnology and Biological Sciences Research Council (BBSRC), project reference 1810028. Publisher Copyright: © 2022 IEEE.

PY - 2022/12/1

Y1 - 2022/12/1

N2 - Ultrasound (US) smart capsules are being developed with the potential to deliver medication via sonoporation in the intestine. However, a layer of mucus that can represent a barrier lines the luminal surface of the intestine. Consequently, it is important to study the propagation of US through mucus to the underlying mucosal cell layer. In order to promote sonoporation, it must be ensured that US propagates efficiently though the mucus, reaches sonoporation agents, such as microbubbles, and thus promotes cavitation. The objective of this work was to investigate the acoustic transparency of mucus. A 7 mm thick layer of mucus caused attenuation of 0.93 ± 0.16 dB/cm for a 4 MHz US signal. When controlled for the thickness of the mucus in the small intestine, mucus reduced the signal amplitude by 0.01 - 0.2%. Notably, the outcomes of this work are also relevant to US therapeutic devices acting in other cavities lined by mucus, such as the respiratory, excretory and female reproductive tracts.

AB - Ultrasound (US) smart capsules are being developed with the potential to deliver medication via sonoporation in the intestine. However, a layer of mucus that can represent a barrier lines the luminal surface of the intestine. Consequently, it is important to study the propagation of US through mucus to the underlying mucosal cell layer. In order to promote sonoporation, it must be ensured that US propagates efficiently though the mucus, reaches sonoporation agents, such as microbubbles, and thus promotes cavitation. The objective of this work was to investigate the acoustic transparency of mucus. A 7 mm thick layer of mucus caused attenuation of 0.93 ± 0.16 dB/cm for a 4 MHz US signal. When controlled for the thickness of the mucus in the small intestine, mucus reduced the signal amplitude by 0.01 - 0.2%. Notably, the outcomes of this work are also relevant to US therapeutic devices acting in other cavities lined by mucus, such as the respiratory, excretory and female reproductive tracts.

KW - acoustic transparency

KW - barrier function

KW - drug delivery

KW - mucus

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DO - 10.1109/IUS54386.2022.9958505

M3 - Conference contribution

AN - SCOPUS:85143793759

SN - 9781665478137

BT - 2022 IEEE International Ultrasonics Symposium (IUS)

PB - IEEE

T2 - 2022 IEEE International Ultrasonics Symposium

Y2 - 10 October 2022 through 13 October 2022

ER -

Investigation into the acoustic transparency of reconstituted mucus

Abstract

Publication series

Conference

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Sonopill: Minimally Invasive Gastrointestinal Diagnosis and Therapy (Joint with University of Glasgow & Heriot Watt University)

Cite this

Investigation into the acoustic transparency of reconstituted mucus

Abstract

Publication series

Conference

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Projects

Sonopill: Minimally Invasive Gastrointestinal Diagnosis and Therapy (Joint with University of Glasgow & Heriot Watt University)

Cite this