Investigation into the acoustic transparency of reconstituted mucus

Mihnea V. Turcanu, Manlio Tassieri, Maya Thanou, Inke Nathke, Sandy Cochran

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    1 Citation (Scopus)
    23 Downloads (Pure)

    Abstract

    Ultrasound (US) smart capsules are being developed with the potential to deliver medication via sonoporation in the intestine. However, a layer of mucus that can represent a barrier lines the luminal surface of the intestine. Consequently, it is important to study the propagation of US through mucus to the underlying mucosal cell layer. In order to promote sonoporation, it must be ensured that US propagates efficiently though the mucus, reaches sonoporation agents, such as microbubbles, and thus promotes cavitation. The objective of this work was to investigate the acoustic transparency of mucus. A 7 mm thick layer of mucus caused attenuation of 0.93 ± 0.16 dB/cm for a 4 MHz US signal. When controlled for the thickness of the mucus in the small intestine, mucus reduced the signal amplitude by 0.01 - 0.2%. Notably, the outcomes of this work are also relevant to US therapeutic devices acting in other cavities lined by mucus, such as the respiratory, excretory and female reproductive tracts.

    Original languageEnglish
    Title of host publication2022 IEEE International Ultrasonics Symposium (IUS)
    PublisherIEEE
    Number of pages3
    ISBN (Electronic)9781665466578
    ISBN (Print)9781665478137
    DOIs
    Publication statusPublished - 1 Dec 2022
    Event2022 IEEE International Ultrasonics Symposium - Venice, Italy
    Duration: 10 Oct 202213 Oct 2022

    Publication series

    Name
    ISSN (Print)1948-5719
    ISSN (Electronic)1948-5727

    Conference

    Conference2022 IEEE International Ultrasonics Symposium
    Abbreviated titleIUS 2022
    Country/TerritoryItaly
    CityVenice
    Period10/10/2213/10/22

    Keywords

    • acoustic transparency
    • barrier function
    • drug delivery
    • mucus

    ASJC Scopus subject areas

    • Acoustics and Ultrasonics

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