Investigation into the acoustic transparency of reconstituted mucus

Mihnea V. Turcanu, Manlio Tassieri, Maya Thanou, Inke Nathke, Sandy Cochran

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Ultrasound (US) smart capsules are being developed with the potential to deliver medication via sonoporation in the intestine. However, a layer of mucus that can represent a barrier lines the luminal surface of the intestine. Consequently, it is important to study the propagation of US through mucus to the underlying mucosal cell layer. In order to promote sonoporation, it must be ensured that US propagates efficiently though the mucus, reaches sonoporation agents, such as microbubbles, and thus promotes cavitation. The objective of this work was to investigate the acoustic transparency of mucus. A 7 mm thick layer of mucus caused attenuation of 0.93 ± 0.16 dB/cm for a 4 MHz US signal. When controlled for the thickness of the mucus in the small intestine, mucus reduced the signal amplitude by 0.01 - 0.2%. Notably, the outcomes of this work are also relevant to US therapeutic devices acting in other cavities lined by mucus, such as the respiratory, excretory and female reproductive tracts.

Original languageEnglish
Title of host publication2022 IEEE International Ultrasonics Symposium (IUS)
PublisherIEEE Computer Society
Number of pages3
ISBN (Electronic)9781665466578
ISBN (Print)9781665478137
DOIs
Publication statusE-pub ahead of print - 1 Dec 2022
Event2022 IEEE International Ultrasonics Symposium - Venice, Italy
Duration: 10 Oct 202213 Oct 2022

Publication series

NameIEEE International Ultrasonics Symposium, IUS
PublisherIEEE
Volume2022-October
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Conference

Conference2022 IEEE International Ultrasonics Symposium
Abbreviated titleIUS 2022
Country/TerritoryItaly
CityVenice
Period10/10/2213/10/22

Keywords

  • acoustic transparency
  • barrier function
  • drug delivery
  • mucus

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