Invitro investigation of the individual contributions of ultrasound-induced stable and inertial cavitation in targeted drug delivery

Dana Gourevich, Alexander Volovick, Osnat Dogadkin, Lijun Wang, Helen Mulvana, Yoav Medan, Andreas Melzer, Sandy Cochran (Lead / Corresponding author)

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)

    Abstract

    Ultrasound-mediated targeted drug delivery is a therapeutic modality under development with the potential to treat cancer. Its ability to produce local hyperthermia and cell poration through cavitation non-invasively makes it a candidate to trigger drug delivery. Hyperthermia offers greater potential for control, particularly with magnetic resonance imaging temperature measurement. However, cavitation may offer reduced treatment times, with real-time measurement of ultrasonic spectra indicating drug dose and treatment success. Here, a clinical magnetic resonance imaging-guided focused ultrasound surgery system was used to study ultrasound-mediated targeted drug delivery in vitro. Drug uptake into breast cancer cells in the vicinity of ultrasound contrast agent was correlated with occurrence and quantity of stable and inertial cavitation, classified according to subharmonic spectra. During stable cavitation, intracellular drug uptake increased by a factor up to 3.2 compared with the control. Reported here are the value of cavitation monitoring with a clinical system and its subsequent employment for dose optimization.

    Original languageEnglish
    Pages (from-to)1853-1864
    Number of pages12
    JournalUltrasound in Medicine and Biology
    Volume41
    Issue number7
    Early online date14 Apr 2015
    DOIs
    Publication statusPublished - Jul 2015

    Keywords

    • Cancer cell
    • Cavitation
    • Focused ultrasound
    • Microbubbles
    • Subharmonic
    • Targeted drug delivery
    • Ultrasound contrast agent

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