Ion Channel Regulation by AMPK: The Route of Hypoxia-Response Coupling in the Carotid Body and Pulmonary Artery

A. Mark Evans; D. Grahame Hardie; Chris Peers; Christopher N. Wyatt; Benoit Viollet; Prem Kumar; Mark L. Dallas; Fiona Ross; Naoko Ikematsu; Heidi L. Jordan; Barbara L. Barr; J. Nicole Rafferty; Oluseye Ogunbayo

doi:10.1111/j.1749-6632.2009.05041.x

Ion Channel Regulation by AMPK: The Route of Hypoxia-Response Coupling in the Carotid Body and Pulmonary Artery

A. Mark Evans, D. Grahame Hardie, Chris Peers, Christopher N. Wyatt, Benoit Viollet, Prem Kumar, Mark L. Dallas, Fiona Ross, Naoko Ikematsu, Heidi L. Jordan, Barbara L. Barr, J. Nicole Rafferty, Oluseye Ogunbayo

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

38 Citations (Scopus)

Abstract

Vital homeostatic mechanisms monitor O-2 supply and adjust respiratory and circulatory function to meet demand. The pulmonary arteries and carotid bodies are key systems in this respect. Hypoxic pulmonary vasoconstriction (HPV) aids ventilation-perfusion matching in the lung by diverting blood flow from areas with an O-2 deficit to those rich in O-2, while a fall in arterial pO(2) increases sensory afferent discharge from the carotid body to elicit corrective changes in breathing patterns. We discuss here the new concept that hypoxia, by inhibiting oxidative phosphorylation, activates AMP-activated protein kinase (AMPK) leading to consequent phosphorylation of target proteins, such as ion channels, which initiate pulmonary artery constriction and carotid body activation. Consistent with this view, AMPK knockout mice exhibit an impaired ventilatory response to hypoxia. Thus, AMPK may be sufficient and necessary for hypoxia-response coupling and may regulate O-2 and thereby energy (ATP) supply at the whole body as well as the cellular level.

Original language	English
Title of host publication	Hypoxia and Consequences From Molecule to Malady
Editors	C. Peers, G. G. Haddad, N. S. Chandel
Place of Publication	Oxford
Publisher	Blackwell
Pages	89-100
Number of pages	12
ISBN (Print)	9781573317733
DOIs	https://doi.org/10.1111/j.1749-6632.2009.05041.x
Publication status	Published - 2009
Event	Conference on Hypoxia and Consequences - From Molecule to Malady - New York, United States Duration: 12 Mar 2009 → 14 Mar 2009

Publication series

Name	Annals of the New York Academy of Sciences
Volume	1177

Conference

Conference	Conference on Hypoxia and Consequences - From Molecule to Malady
Country/Territory	United States
City	New York
Period	12/03/09 → 14/03/09

Keywords

AMP-activated protein kinase (AMPK)
hypoxia
calcium
carotid body
pulmonary artery
hypoxic pulmonary vasoconstriction (HPV)
ACTIVATED PROTEIN-KINASE
CYCLIC ADP-RIBOSE
ADRENOMEDULLARY CHROMAFFIN CELLS
SMOOTH-MUSCLE-CELLS
CHEMORECEPTOR CELLS
K+ CURRENT
I CELLS
GLUCOSE-TRANSPORT
O-2-SENSING CELLS
ENERGY

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/j.1749-6632.2009.05041.x

Cite this

Evans, A. M., Hardie, D. G., Peers, C., Wyatt, C. N., Viollet, B., Kumar, P., Dallas, M. L., Ross, F., Ikematsu, N., Jordan, H. L., Barr, B. L., Rafferty, J. N., & Ogunbayo, O. (2009). Ion Channel Regulation by AMPK: The Route of Hypoxia-Response Coupling in the Carotid Body and Pulmonary Artery. In C. Peers, G. G. Haddad, & N. S. Chandel (Eds.), Hypoxia and Consequences From Molecule to Malady (pp. 89-100). (Annals of the New York Academy of Sciences; Vol. 1177). Blackwell. https://doi.org/10.1111/j.1749-6632.2009.05041.x

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title = "Ion Channel Regulation by AMPK: The Route of Hypoxia-Response Coupling in the Carotid Body and Pulmonary Artery",

abstract = "Vital homeostatic mechanisms monitor O-2 supply and adjust respiratory and circulatory function to meet demand. The pulmonary arteries and carotid bodies are key systems in this respect. Hypoxic pulmonary vasoconstriction (HPV) aids ventilation-perfusion matching in the lung by diverting blood flow from areas with an O-2 deficit to those rich in O-2, while a fall in arterial pO(2) increases sensory afferent discharge from the carotid body to elicit corrective changes in breathing patterns. We discuss here the new concept that hypoxia, by inhibiting oxidative phosphorylation, activates AMP-activated protein kinase (AMPK) leading to consequent phosphorylation of target proteins, such as ion channels, which initiate pulmonary artery constriction and carotid body activation. Consistent with this view, AMPK knockout mice exhibit an impaired ventilatory response to hypoxia. Thus, AMPK may be sufficient and necessary for hypoxia-response coupling and may regulate O-2 and thereby energy (ATP) supply at the whole body as well as the cellular level.",

keywords = "AMP-activated protein kinase (AMPK), hypoxia, calcium, carotid body, pulmonary artery, hypoxic pulmonary vasoconstriction (HPV), ACTIVATED PROTEIN-KINASE, CYCLIC ADP-RIBOSE, ADRENOMEDULLARY CHROMAFFIN CELLS, SMOOTH-MUSCLE-CELLS, CHEMORECEPTOR CELLS, K+ CURRENT, I CELLS, GLUCOSE-TRANSPORT, O-2-SENSING CELLS, ENERGY",

author = "Evans, {A. Mark} and Hardie, {D. Grahame} and Chris Peers and Wyatt, {Christopher N.} and Benoit Viollet and Prem Kumar and Dallas, {Mark L.} and Fiona Ross and Naoko Ikematsu and Jordan, {Heidi L.} and Barr, {Barbara L.} and Rafferty, {J. Nicole} and Oluseye Ogunbayo",

year = "2009",

doi = "10.1111/j.1749-6632.2009.05041.x",

language = "English",

isbn = "9781573317733",

series = "Annals of the New York Academy of Sciences",

publisher = "Blackwell",

pages = "89--100",

editor = "C. Peers and Haddad, {G. G.} and Chandel, {N. S.}",

booktitle = "Hypoxia and Consequences From Molecule to Malady",

note = "Conference on Hypoxia and Consequences - From Molecule to Malady ; Conference date: 12-03-2009 Through 14-03-2009",

}

Evans, AM, Hardie, DG, Peers, C, Wyatt, CN, Viollet, B, Kumar, P, Dallas, ML, Ross, F, Ikematsu, N, Jordan, HL, Barr, BL, Rafferty, JN & Ogunbayo, O 2009, Ion Channel Regulation by AMPK: The Route of Hypoxia-Response Coupling in the Carotid Body and Pulmonary Artery. in C Peers, GG Haddad & NS Chandel (eds), Hypoxia and Consequences From Molecule to Malady. Annals of the New York Academy of Sciences, vol. 1177, Blackwell, Oxford, pp. 89-100, Conference on Hypoxia and Consequences - From Molecule to Malady, New York, United States, 12/03/09. https://doi.org/10.1111/j.1749-6632.2009.05041.x

Ion Channel Regulation by AMPK: The Route of Hypoxia-Response Coupling in the Carotid Body and Pulmonary Artery. / Evans, A. Mark; Hardie, D. Grahame; Peers, Chris et al.
Hypoxia and Consequences From Molecule to Malady. ed. / C. Peers; G. G. Haddad; N. S. Chandel. Oxford: Blackwell, 2009. p. 89-100 (Annals of the New York Academy of Sciences; Vol. 1177).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Ion Channel Regulation by AMPK

T2 - Conference on Hypoxia and Consequences - From Molecule to Malady

AU - Evans, A. Mark

AU - Hardie, D. Grahame

AU - Peers, Chris

AU - Wyatt, Christopher N.

AU - Viollet, Benoit

AU - Kumar, Prem

AU - Dallas, Mark L.

AU - Ross, Fiona

AU - Ikematsu, Naoko

AU - Jordan, Heidi L.

AU - Barr, Barbara L.

AU - Rafferty, J. Nicole

AU - Ogunbayo, Oluseye

PY - 2009

Y1 - 2009

N2 - Vital homeostatic mechanisms monitor O-2 supply and adjust respiratory and circulatory function to meet demand. The pulmonary arteries and carotid bodies are key systems in this respect. Hypoxic pulmonary vasoconstriction (HPV) aids ventilation-perfusion matching in the lung by diverting blood flow from areas with an O-2 deficit to those rich in O-2, while a fall in arterial pO(2) increases sensory afferent discharge from the carotid body to elicit corrective changes in breathing patterns. We discuss here the new concept that hypoxia, by inhibiting oxidative phosphorylation, activates AMP-activated protein kinase (AMPK) leading to consequent phosphorylation of target proteins, such as ion channels, which initiate pulmonary artery constriction and carotid body activation. Consistent with this view, AMPK knockout mice exhibit an impaired ventilatory response to hypoxia. Thus, AMPK may be sufficient and necessary for hypoxia-response coupling and may regulate O-2 and thereby energy (ATP) supply at the whole body as well as the cellular level.

AB - Vital homeostatic mechanisms monitor O-2 supply and adjust respiratory and circulatory function to meet demand. The pulmonary arteries and carotid bodies are key systems in this respect. Hypoxic pulmonary vasoconstriction (HPV) aids ventilation-perfusion matching in the lung by diverting blood flow from areas with an O-2 deficit to those rich in O-2, while a fall in arterial pO(2) increases sensory afferent discharge from the carotid body to elicit corrective changes in breathing patterns. We discuss here the new concept that hypoxia, by inhibiting oxidative phosphorylation, activates AMP-activated protein kinase (AMPK) leading to consequent phosphorylation of target proteins, such as ion channels, which initiate pulmonary artery constriction and carotid body activation. Consistent with this view, AMPK knockout mice exhibit an impaired ventilatory response to hypoxia. Thus, AMPK may be sufficient and necessary for hypoxia-response coupling and may regulate O-2 and thereby energy (ATP) supply at the whole body as well as the cellular level.

KW - AMP-activated protein kinase (AMPK)

KW - hypoxia

KW - calcium

KW - carotid body

KW - pulmonary artery

KW - hypoxic pulmonary vasoconstriction (HPV)

KW - ACTIVATED PROTEIN-KINASE

KW - CYCLIC ADP-RIBOSE

KW - ADRENOMEDULLARY CHROMAFFIN CELLS

KW - SMOOTH-MUSCLE-CELLS

KW - CHEMORECEPTOR CELLS

KW - K+ CURRENT

KW - I CELLS

KW - GLUCOSE-TRANSPORT

KW - O-2-SENSING CELLS

KW - ENERGY

U2 - 10.1111/j.1749-6632.2009.05041.x

DO - 10.1111/j.1749-6632.2009.05041.x

M3 - Conference contribution

C2 - 19845611

SN - 9781573317733

T3 - Annals of the New York Academy of Sciences

SP - 89

EP - 100

BT - Hypoxia and Consequences From Molecule to Malady

A2 - Peers, C.

A2 - Haddad, G. G.

A2 - Chandel, N. S.

PB - Blackwell

CY - Oxford

Y2 - 12 March 2009 through 14 March 2009

ER -

Evans AM, Hardie DG, Peers C, Wyatt CN, Viollet B, Kumar P et al. Ion Channel Regulation by AMPK: The Route of Hypoxia-Response Coupling in the Carotid Body and Pulmonary Artery. In Peers C, Haddad GG, Chandel NS, editors, Hypoxia and Consequences From Molecule to Malady. Oxford: Blackwell. 2009. p. 89-100. (Annals of the New York Academy of Sciences). doi: 10.1111/j.1749-6632.2009.05041.x

Ion Channel Regulation by AMPK: The Route of Hypoxia-Response Coupling in the Carotid Body and Pulmonary Artery

Abstract

Publication series

Conference

Keywords

UN SDGs

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