Is REDD1 a Metabolic Éminence Grise?

Christopher Lipina; Harinder Hundal

doi:10.1016/j.tem.2016.08.005

Is REDD1 a Metabolic Éminence Grise?

Christopher Lipina, Harinder Hundal (Lead / Corresponding author)

Cell Signalling and Immunology

Research output: Contribution to journal › Review article

16 Citations (Scopus)

111 Downloads (Pure)

Abstract

Regulated in development and DNA damage response 1 (REDD1) has been functionally linked to the control of diverse cellular processes due, at least in part, to its ability to repress mTORC1, a key protein complex controlled by hormonal and nutrient cues. Notably, emerging evidence suggests that REDD1 may also regulate a number of pathways involved in modulating energy balance and metabolism. Herein, we discuss evidence implicating REDD1 as a key modulator of insulin action and metabolic function, including its potential contribution to mitochondrial biology and pancreatic islet function. Collectively, the available evidence suggests that REDD1 may play a more prominent role in energy homeostasis than previously thought, and implicates REDD1 as a potential therapeutic target for treatment of metabolic disorders.

Original language	English
Pages (from-to)	868-880
Number of pages	13
Journal	Trends in Endocrinology and Metabolism
Volume	27
Issue number	12
Early online date	6 Sep 2016
DOIs	https://doi.org/10.1016/j.tem.2016.08.005
Publication status	Published - Dec 2016

Fingerprint

Aptitude

Islets of Langerhans

Energy Metabolism

DNA Damage

Cues

Homeostasis

Insulin

Food

Proteins

Therapeutics

mechanistic target of rapamycin complex 1

Keywords

REDD1
skeletal muscle
insulin
protein kinase B
Akt
mTOR
obesity

Cite this

Lipina, C., & Hundal, H. (2016). Is REDD1 a Metabolic Éminence Grise? Trends in Endocrinology and Metabolism, 27(12), 868-880. https://doi.org/10.1016/j.tem.2016.08.005

Lipina, Christopher ; Hundal, Harinder. / Is REDD1 a Metabolic Éminence Grise?. In: Trends in Endocrinology and Metabolism. 2016 ; Vol. 27, No. 12. pp. 868-880.

@article{dcf37e4f9d45462da1c045bf2443832c,

title = "Is REDD1 a Metabolic {\'E}minence Grise?",

abstract = "Regulated in development and DNA damage response 1 (REDD1) has been functionally linked to the control of diverse cellular processes due, at least in part, to its ability to repress mTORC1, a key protein complex controlled by hormonal and nutrient cues. Notably, emerging evidence suggests that REDD1 may also regulate a number of pathways involved in modulating energy balance and metabolism. Herein, we discuss evidence implicating REDD1 as a key modulator of insulin action and metabolic function, including its potential contribution to mitochondrial biology and pancreatic islet function. Collectively, the available evidence suggests that REDD1 may play a more prominent role in energy homeostasis than previously thought, and implicates REDD1 as a potential therapeutic target for treatment of metabolic disorders.",

keywords = "REDD1, skeletal muscle, insulin, protein kinase B, Akt, mTOR, obesity",

author = "Christopher Lipina and Harinder Hundal",

note = "Funding: BBSRC and Diabetes UK.",

year = "2016",

month = "12",

doi = "10.1016/j.tem.2016.08.005",

language = "English",

volume = "27",

pages = "868--880",

journal = "Trends in Endocrinology and Metabolism",

issn = "1043-2760",

publisher = "Elsevier",

number = "12",

}

Lipina, C & Hundal, H 2016, 'Is REDD1 a Metabolic Éminence Grise?', Trends in Endocrinology and Metabolism, vol. 27, no. 12, pp. 868-880. https://doi.org/10.1016/j.tem.2016.08.005