Projects per year
Abstract
Regulated in development and DNA damage response 1 (REDD1) has been functionally linked to the control of diverse cellular processes due, at least in part, to its ability to repress mTORC1, a key protein complex controlled by hormonal and nutrient cues. Notably, emerging evidence suggests that REDD1 may also regulate a number of pathways involved in modulating energy balance and metabolism. Herein, we discuss evidence implicating REDD1 as a key modulator of insulin action and metabolic function, including its potential contribution to mitochondrial biology and pancreatic islet function. Collectively, the available evidence suggests that REDD1 may play a more prominent role in energy homeostasis than previously thought, and implicates REDD1 as a potential therapeutic target for treatment of metabolic disorders.
Original language | English |
---|---|
Pages (from-to) | 868-880 |
Number of pages | 13 |
Journal | Trends in Endocrinology and Metabolism |
Volume | 27 |
Issue number | 12 |
Early online date | 6 Sep 2016 |
DOIs | |
Publication status | Published - Dec 2016 |
Keywords
- REDD1
- skeletal muscle
- insulin
- protein kinase B
- Akt
- mTOR
- obesity
Fingerprint
Dive into the research topics of 'Is REDD1 a Metabolic Éminence Grise?'. Together they form a unique fingerprint.Projects
- 2 Finished
-
Wellcome Trust PhD Studentship
Cowling, V., Owen-Hughes, T. & Ryan, R.
1/09/15 → 5/09/19
Project: Research