Is REDD1 a Metabolic Éminence Grise?

Regulated in development and DNA damage response 1 (REDD1) has been functionally linked to the control of diverse cellular processes due, at least in part, to its ability to repress mTORC1, a key protein complex controlled by hormonal and nutrient cues. Notably, emerging evidence suggests that REDD1 may also regulate a number of pathways involved in modulating energy balance and metabolism. Herein, we discuss evidence implicating REDD1 as a key modulator of insulin action and metabolic function, including its potential contribution to mitochondrial biology and pancreatic islet function. Collectively, the available evidence suggests that REDD1 may play a more prominent role in energy homeostasis than previously thought, and implicates REDD1 as a potential therapeutic target for treatment of metabolic disorders.