Is REDD1 a Metabolic Éminence Grise?

Christopher Lipina, Harinder Hundal (Lead / Corresponding author)

Research output: Contribution to journalReview article

16 Citations (Scopus)
99 Downloads (Pure)

Abstract

Regulated in development and DNA damage response 1 (REDD1) has been functionally linked to the control of diverse cellular processes due, at least in part, to its ability to repress mTORC1, a key protein complex controlled by hormonal and nutrient cues. Notably, emerging evidence suggests that REDD1 may also regulate a number of pathways involved in modulating energy balance and metabolism. Herein, we discuss evidence implicating REDD1 as a key modulator of insulin action and metabolic function, including its potential contribution to mitochondrial biology and pancreatic islet function. Collectively, the available evidence suggests that REDD1 may play a more prominent role in energy homeostasis than previously thought, and implicates REDD1 as a potential therapeutic target for treatment of metabolic disorders.
Original languageEnglish
Pages (from-to)868-880
Number of pages13
JournalTrends in Endocrinology and Metabolism
Volume27
Issue number12
Early online date6 Sep 2016
DOIs
Publication statusPublished - Dec 2016

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Aptitude
Islets of Langerhans
Energy Metabolism
DNA Damage
Cues
Homeostasis
Insulin
Food
Proteins
Therapeutics
mechanistic target of rapamycin complex 1

Keywords

  • REDD1
  • skeletal muscle
  • insulin
  • protein kinase B
  • Akt
  • mTOR
  • obesity

Cite this

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title = "Is REDD1 a Metabolic {\'E}minence Grise?",
abstract = "Regulated in development and DNA damage response 1 (REDD1) has been functionally linked to the control of diverse cellular processes due, at least in part, to its ability to repress mTORC1, a key protein complex controlled by hormonal and nutrient cues. Notably, emerging evidence suggests that REDD1 may also regulate a number of pathways involved in modulating energy balance and metabolism. Herein, we discuss evidence implicating REDD1 as a key modulator of insulin action and metabolic function, including its potential contribution to mitochondrial biology and pancreatic islet function. Collectively, the available evidence suggests that REDD1 may play a more prominent role in energy homeostasis than previously thought, and implicates REDD1 as a potential therapeutic target for treatment of metabolic disorders.",
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author = "Christopher Lipina and Harinder Hundal",
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Is REDD1 a Metabolic Éminence Grise? / Lipina, Christopher; Hundal, Harinder (Lead / Corresponding author).

In: Trends in Endocrinology and Metabolism, Vol. 27, No. 12, 12.2016, p. 868-880.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Is REDD1 a Metabolic Éminence Grise?

AU - Lipina, Christopher

AU - Hundal, Harinder

N1 - Funding: BBSRC and Diabetes UK.

PY - 2016/12

Y1 - 2016/12

N2 - Regulated in development and DNA damage response 1 (REDD1) has been functionally linked to the control of diverse cellular processes due, at least in part, to its ability to repress mTORC1, a key protein complex controlled by hormonal and nutrient cues. Notably, emerging evidence suggests that REDD1 may also regulate a number of pathways involved in modulating energy balance and metabolism. Herein, we discuss evidence implicating REDD1 as a key modulator of insulin action and metabolic function, including its potential contribution to mitochondrial biology and pancreatic islet function. Collectively, the available evidence suggests that REDD1 may play a more prominent role in energy homeostasis than previously thought, and implicates REDD1 as a potential therapeutic target for treatment of metabolic disorders.

AB - Regulated in development and DNA damage response 1 (REDD1) has been functionally linked to the control of diverse cellular processes due, at least in part, to its ability to repress mTORC1, a key protein complex controlled by hormonal and nutrient cues. Notably, emerging evidence suggests that REDD1 may also regulate a number of pathways involved in modulating energy balance and metabolism. Herein, we discuss evidence implicating REDD1 as a key modulator of insulin action and metabolic function, including its potential contribution to mitochondrial biology and pancreatic islet function. Collectively, the available evidence suggests that REDD1 may play a more prominent role in energy homeostasis than previously thought, and implicates REDD1 as a potential therapeutic target for treatment of metabolic disorders.

KW - REDD1

KW - skeletal muscle

KW - insulin

KW - protein kinase B

KW - Akt

KW - mTOR

KW - obesity

U2 - 10.1016/j.tem.2016.08.005

DO - 10.1016/j.tem.2016.08.005

M3 - Review article

C2 - 27613400

VL - 27

SP - 868

EP - 880

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

SN - 1043-2760

IS - 12

ER -