Is REDD1 a Metabolic Éminence Grise?

Christopher Lipina, Harinder Hundal (Lead / Corresponding author)

Research output: Contribution to journalReview article

19 Citations (Scopus)
164 Downloads (Pure)

Abstract

Regulated in development and DNA damage response 1 (REDD1) has been functionally linked to the control of diverse cellular processes due, at least in part, to its ability to repress mTORC1, a key protein complex controlled by hormonal and nutrient cues. Notably, emerging evidence suggests that REDD1 may also regulate a number of pathways involved in modulating energy balance and metabolism. Herein, we discuss evidence implicating REDD1 as a key modulator of insulin action and metabolic function, including its potential contribution to mitochondrial biology and pancreatic islet function. Collectively, the available evidence suggests that REDD1 may play a more prominent role in energy homeostasis than previously thought, and implicates REDD1 as a potential therapeutic target for treatment of metabolic disorders.
Original languageEnglish
Pages (from-to)868-880
Number of pages13
JournalTrends in Endocrinology and Metabolism
Volume27
Issue number12
Early online date6 Sep 2016
DOIs
Publication statusPublished - Dec 2016

Keywords

  • REDD1
  • skeletal muscle
  • insulin
  • protein kinase B
  • Akt
  • mTOR
  • obesity

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