Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 868-880 |
| Number of pages | 13 |
| Journal | Trends in Endocrinology and Metabolism |
| Volume | 27 |
| Issue number | 12 |
| Early online date | 6 Sep 2016 |
| DOIs | |
| Publication status | Published - Dec 2016 |
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Keywords
- REDD1
- skeletal muscle
- insulin
- protein kinase B
- Akt
- mTOR
- obesity
Cite this
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Is REDD1 a Metabolic Éminence Grise? / Lipina, Christopher; Hundal, Harinder (Lead / Corresponding author).
In: Trends in Endocrinology and Metabolism, Vol. 27, No. 12, 12.2016, p. 868-880.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Is REDD1 a Metabolic Éminence Grise?
AU - Lipina, Christopher
AU - Hundal, Harinder
N1 - Funding: BBSRC and Diabetes UK.
PY - 2016/12
Y1 - 2016/12
N2 - Regulated in development and DNA damage response 1 (REDD1) has been functionally linked to the control of diverse cellular processes due, at least in part, to its ability to repress mTORC1, a key protein complex controlled by hormonal and nutrient cues. Notably, emerging evidence suggests that REDD1 may also regulate a number of pathways involved in modulating energy balance and metabolism. Herein, we discuss evidence implicating REDD1 as a key modulator of insulin action and metabolic function, including its potential contribution to mitochondrial biology and pancreatic islet function. Collectively, the available evidence suggests that REDD1 may play a more prominent role in energy homeostasis than previously thought, and implicates REDD1 as a potential therapeutic target for treatment of metabolic disorders.
AB - Regulated in development and DNA damage response 1 (REDD1) has been functionally linked to the control of diverse cellular processes due, at least in part, to its ability to repress mTORC1, a key protein complex controlled by hormonal and nutrient cues. Notably, emerging evidence suggests that REDD1 may also regulate a number of pathways involved in modulating energy balance and metabolism. Herein, we discuss evidence implicating REDD1 as a key modulator of insulin action and metabolic function, including its potential contribution to mitochondrial biology and pancreatic islet function. Collectively, the available evidence suggests that REDD1 may play a more prominent role in energy homeostasis than previously thought, and implicates REDD1 as a potential therapeutic target for treatment of metabolic disorders.
KW - REDD1
KW - skeletal muscle
KW - insulin
KW - protein kinase B
KW - Akt
KW - mTOR
KW - obesity
U2 - 10.1016/j.tem.2016.08.005
DO - 10.1016/j.tem.2016.08.005
M3 - Review article
C2 - 27613400
VL - 27
SP - 868
EP - 880
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
SN - 1043-2760
IS - 12
ER -